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Rabbit Recombinant Monoclonal CD23 antibody. Carrier free. Suitable for ICC, Flow Cyt and reacts with Mouse samples. Immunogen corresponding to Recombinant Fragment Protein within Mouse FCER2_MOUSE.

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Images

Flow Cytometry - Anti-CD23 antibody [007] - BSA and Azide free (AB277131), expandable thumbnail
  • Immunocytochemistry - Anti-CD23 antibody [007] - BSA and Azide free (AB277131), expandable thumbnail

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

Constituents: 100% PBS

Form

Liquid

Clonality

Monoclonal

Immunogen

  • Recombinant Fragment Protein within Mouse FCER2_MOUSE. Database link P20693

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
ICCFlow Cyt
Mouse
Tested
Tested

Tested
Tested

Species

Mouse

Dilution info

1/20.00000 - 1/100.00000

Notes

-

Tested
Tested

Species

Mouse

Dilution info

1/25.00000 - 1/100.00000

Notes

-

Associated Products

Select an associated product type

2 products for Alternative Version

Target data

Function

Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).

Alternative names

Low affinity immunoglobulin epsilon Fc receptor, Fc-epsilon-RII, Lymphocyte IgE receptor, Fcer2a, Fcer2

Recommended products

Rabbit Recombinant Monoclonal CD23 antibody. Carrier free. Suitable for ICC, Flow Cyt and reacts with Mouse samples. Immunogen corresponding to Recombinant Fragment Protein within Mouse FCER2_MOUSE.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Monoclonal

Immunogen
  • Recombinant Fragment Protein within Mouse FCER2_MOUSE. Database link P20693
Carrier free

Yes

Clone number

007

Purification technique

Affinity purification Protein A

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate long-term storage conditions

+4°C

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

CD23 also known as Fc epsilon receptor II (FcεRII) or BU38 is a type II integral membrane protein with a molecular mass of approximately 45 kDa. It is expressed mainly on B cells but also appears on various other cell types such as macrophages eosinophils and Langerhans cells. CD23 expression occurs in both soluble and membrane-bound forms. The protein consists of a lectin-like extracellular domain a short transmembrane domain and a cytoplasmic tail.

Biological function summary

CD23 facilitates several immune functions including the regulation of immunoglobulin E (IgE) production and its receptor-mediated endocytosis. It has a role in cell adhesion growth and differentiation. CD23 exists independently localizing primarily to the surface of CD23-positive cells. Furthermore this protein influences the release and activity of various cytokines impacting both innate and adaptive immunity.

Pathways

CD23 plays central roles in IgE-mediated immune responses and allergic reactions. It is importantly involved in the synthesis and regulation of IgE connecting it to the IgE signaling pathway and immune system pathways. CD23 interacts with IgE and its receptors which include the high-affinity receptor FcεRI forming an interface between the antigen and immune effector functions. Additionally CD23 participates in pathways that involve immune response modulation and inflammation prevention.

Associated diseases and disorders

CD23 is most notably associated with allergic diseases such as asthma and allergic rhinitis due to its role in IgE regulation. It is also linked to chronic lymphocytic leukemia (CLL) in which CD23 serves as a marker for disease progression. In CLL interactions involving CD23 and related proteins such as BCMA and BAFF have been studied to better understand the disorder and its treatment. Anti-CD23 antibodies have been used as both diagnostic tools and therapeutic agents to target CD23-positive cells in these diseases.

Product promise

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In the unlikely event of one of our products not working as expected, you are covered by our product promise.

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2 product images

  • Flow Cytometry - Anti-CD23 antibody [007] - BSA and Azide free (ab277131), expandable thumbnail

    Flow Cytometry - Anti-CD23 antibody [007] - BSA and Azide free (ab277131)

    Flow cytometric analysis of CD23 expression on BABL/c splenocytes. Cells were stained with ab277131 at 1/25 dilution, then a FITC-conjugated second step antibody (Black). Cells were also stained with an isotype control (Grey). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.

  • Immunocytochemistry - Anti-CD23 antibody [007] - BSA and Azide free (ab277131), expandable thumbnail

    Immunocytochemistry - Anti-CD23 antibody [007] - BSA and Azide free (ab277131)

    Immunofluorescence staining of CD23 in mouse splenocytes. Cells were fixed with 4% PFA, blocked with 10% serum, and ab277131 at 1/60 dilution at 4°C overnight. Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue).

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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