JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB244478

Anti-CD24 antibody

Be the first to review this product! Submit a review

|

(2 Publications)

Rabbit Polyclonal CD24 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CD24 aa 1 to C-terminus.

View Alternative Names

CD24, CD24A, Signal transducer CD24, Small cell lung carcinoma cluster 4 antigen

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-CD24 antibody (AB244478)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-CD24 antibody (AB244478)

PFA-fixed, Triton X-100 permeabilized RT4 (human urinary bladder cancer cell line) cells stained for CD24 (green) using ab244478 at 4 μg/ml in ICC/IF.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human CD24 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P25063

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD24 also known as heat-stable antigen or CD24A is a glycosylphosphatidylinositol (GPI)-anchored membrane protein with a molecular mass of approximately 30-50 kDa. It is expressed on the surface of many cell types including B cells T cells neutrophils and epithelial cells. CD24 plays a role in cell adhesion and signaling processes impacting immune response and cancer progression. Its expression is often used as a marker in identification and classification procedures such as flow cytometry.
Biological function summary

CD24 functions like a molecular "switch" modulating signals sent between cells. It acts as a ligand for multiple receptors and participates in cellular communication especially influencing the immune system. Part of its biological role involves interaction within cellular complexes impacting immune modulation and inflammatory responses. CD24's location at the interface of cellular microenvironments makes it critical for cellular response adaptation to varied external stimuli.

Pathways

CD24 participates in both immune signaling and cancer-related pathways. It plays a significant role in the suppression of the immune response often interacting with proteins like Siglec-10 in these pathways. CD24's involvement in these pathways contributes to cell survival and proliferation particularly within cancer development. The protein’s interaction within specified signaling pathways allows it to influence downstream targets that regulate gene expression and cellular functions.

CD24 has significant connections to cancer and inflammatory diseases. It is highly expressed in various cancers including breast and prostate cancer where it correlates with poor prognosis due to its role in apoptosis evasion and metastasis. CD24 interacts with proteins like HMGB1 and is implicated in inflammatory conditions where it modulates immune cell activity. Extensive research into CD24's involvement in these disorders may lead to targeted therapies including the development of anti-CD24 antibodies for therapeutic interventions.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells (PubMed : 11313396). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity).
See full target information CD24
style
left-column

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 14:5029 PubMed37596273

2023

Spatial transcriptomics reveals distinct and conserved tumor core and edge architectures that predict survival and targeted therapy response.

Applications

Unspecified application

Species

Unspecified reactive species

Rohit Arora,Christian Cao,Mehul Kumar,Sarthak Sinha,Ayan Chanda,Reid McNeil,Divya Samuel,Rahul K Arora,T Wayne Matthews,Shamir Chandarana,Robert Hart,Joseph C Dort,Jeff Biernaskie,Paola Neri,Martin D Hyrcza,Pinaki Bose

Journal of experimental & clinical cancer research : CR 42:5 PubMed36600258

2023

KLF14 regulates the growth of hepatocellular carcinoma cells via its modulation of iron homeostasis through the repression of iron-responsive element-binding protein 2.

Applications

Unspecified application

Species

Unspecified reactive species

Hui Zhou,Junru Chen,Mingjie Fan,Huajian Cai,Yufei Dong,Yue Qiu,Qianqian Zhuang,Zhaoying Lei,Mengyao Li,Xue Ding,Peng Yan,Aifu Lin,Shusen Zheng,Qingfeng Yan
View all publications
style
left-column
style
left-column
style
right-column

Alternative Products

Primary Antibodies

AB30350

FITC Anti-CD24 antibody [SN3]

Flow Cytometry - FITC Anti-CD24 antibody [SN3] (AB30350)

  • 5
  • 1
Primary Antibodies

AB134375

Anti-CD24 antibody [SN3]

Flow Cytometry - Anti-CD24 antibody [SN3] (AB134375)

  • 5
  • 1
Primary Antibodies

AB179821

Anti-CD24 antibody [EPR3006(N)]

RabMAb|Recombinant

Western blot - Anti-CD24 antibody [EPR3006(N)] (AB179821)

  • 0
  • 0
Primary Antibodies

AB228455

Anti-CD24 antibody [EPR19925] - BSA and Azide free

RabMAb|Recombinant

Flow Cytometry - Anti-CD24 antibody [EPR19925] - BSA and Azide free (AB228455)

  • 1
  • 1
Primary Antibodies

AB202073

Anti-CD24 antibody [EPR19925]

RabMAb|Recombinant|20ul selling size

Flow Cytometry - Anti-CD24 antibody [EPR19925] (AB202073)

  • 4
  • 2

Complementary Products

Primary Antibodies

AB189524

Anti-CD44 antibody [EPR18668]

RabMAb|Recombinant|Lab Essentials|20ul selling size|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD44 antibody [EPR18668] (AB189524)

  • 5
  • 1
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB19898

Anti-CD133 antibody - Stem Cell Marker

Lab Essentials

Western blot - Anti-CD133 antibody - Stem Cell Marker (AB19898)

  • 4
  • 27
Primary Antibodies

AB9485

Anti-GAPDH antibody - Loading Control

BOND RX™ Validated|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-GAPDH antibody - Loading Control (AB9485)

  • 5
  • 88

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com