AB134375

Anti-CD24 antibody [SN3]

Name: Anti-CD24 antibody [SN3] (ab134375) | Abcam
Brand: Abcam Limited
SKU: AB134375
Rating: 5 (1 reviews)

(1 Review)

(12 Publications)

Mouse Monoclonal CD24 antibody. Suitable for Flow Cyt and reacts with Human samples. Cited in 12 publications.

View Alternative Names

CD24, CD24A, Signal transducer CD24, Small cell lung carcinoma cluster 4 antigen

2 Images

Flow Cytometry - Anti-CD24 antibody [SN3] (AB134375)

Flow Cyt

Supplier Data

Flow Cytometry - Anti-CD24 antibody [SN3] (AB134375)

Flow cytometric analysis of Human peripheral whole blood cells labelling CD24 with ab134375 at 4 μg/ml.

Flow Cyt

Supplier Data

Flow Cytometry - Anti-CD24 antibody [SN3] (AB134375)

Flow cytometric analysis of Human peripheral whole blood cells labelling CD24 with ab134375 at 4 μg/ml.

660 APC

APC Anti-CD24 antibody [SN3]
519 FITC

FITC Anti-CD24 antibody [SN3]
695 PerCP/Cy5.5®

PerCP/Cy5.5® Anti-CD24 antibody [SN3]
578 PE

PE Anti-CD24 antibody [SN3]
723 Alexa Fluor® 700

Alexa Fluor® 700 Anti-CD24 antibody [SN3]
785 APC/Cy7®

APC/Cy7® Anti-CD24 antibody [SN3]
578 PE

PE Anti-CD24 antibody [SN3]

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

SN3

Isotype

IgG1

Carrier free

Reacts with

Human

Applications

Flow Cyt

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1-12 µg/mL", "FlowCyt-species-notes": "<p><a href='/en-us/products/primary-antibodies/mouse-igg1-kappa-monoclonal-15-6e10a7-isotype-control-ab170190'>ab170190</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Purification notes

Purity: >95% (by SDS-PAGE).

Storage buffer

pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD24 also known as heat-stable antigen or CD24A is a glycosylphosphatidylinositol (GPI)-anchored membrane protein with a molecular mass of approximately 30-50 kDa. It is expressed on the surface of many cell types including B cells T cells neutrophils and epithelial cells. CD24 plays a role in cell adhesion and signaling processes impacting immune response and cancer progression. Its expression is often used as a marker in identification and classification procedures such as flow cytometry.

Biological function summary

CD24 functions like a molecular "switch" modulating signals sent between cells. It acts as a ligand for multiple receptors and participates in cellular communication especially influencing the immune system. Part of its biological role involves interaction within cellular complexes impacting immune modulation and inflammatory responses. CD24's location at the interface of cellular microenvironments makes it critical for cellular response adaptation to varied external stimuli.

Pathways

CD24 participates in both immune signaling and cancer-related pathways. It plays a significant role in the suppression of the immune response often interacting with proteins like Siglec-10 in these pathways. CD24's involvement in these pathways contributes to cell survival and proliferation particularly within cancer development. The protein's interaction within specified signaling pathways allows it to influence downstream targets that regulate gene expression and cellular functions.

CD24 has significant connections to cancer and inflammatory diseases. It is highly expressed in various cancers including breast and prostate cancer where it correlates with poor prognosis due to its role in apoptosis evasion and metastasis. CD24 interacts with proteins like HMGB1 and is implicated in inflammatory conditions where it modulates immune cell activity. Extensive research into CD24's involvement in these disorders may lead to targeted therapies including the development of anti-CD24 antibodies for therapeutic interventions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells (PubMed : 11313396). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity).

See full target information CD24

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Publications (12)

Recent publications for all applications. Explore the full list and refine your search

JCI insight 9: PubMed38227377

2024

C3aR-initiated signaling is a critical mechanism of podocyte injury in membranous nephropathy.

Applications

Unspecified application

Species

Unspecified reactive species

Qi Zhang,Sofia Bin,Kelly Budge,Astgik Petrosyan,Valentina Villani,Paola Aguiari,Coralien Vink,Jack Wetzels,Hasmik Soloyan,Gaetano La Manna,Manuel Alfredo Podestà,Paolo Molinari,Sargis Sedrakyan,Kevin V Lemley,Roger E De Filippo,Laura Perin,Paolo Cravedi,Stefano Da Sacco

Journal of personalized medicine 13: PubMed37109070

2023

The Composition of Small Extracellular Vesicles (sEVs) in the Blood Plasma of Colorectal Cancer Patients Reflects the Presence of Metabolic Syndrome and Correlates with Angiogenesis and the Effectiveness of Thermoradiation Therapy.

Applications

Unspecified application

Species

Unspecified reactive species

Natalia V Yunusova,Dmitry A Svarovsky,Artem I Konovalov,Dmitry N Kostromitsky,Zhanna A Startseva,Olga V Cheremisina,Sergey G Afanas'ev,Irina V Kondakova,Alina E Grigor'eva,Sergey V Vtorushin,Elena E Sereda,Anna V Usova,Svetlana N Tamkovich

International journal of molecular sciences 24: PubMed36613908

2022

Comparative Analysis of Tumor-Associated microRNAs and Tetraspanines from Exosomes of Plasma and Ascitic Fluids of Ovarian Cancer Patients.

Applications

Unspecified application

Species

Unspecified reactive species

Natalia Yunusova,Ekaterina Dzhugashvili,Alena Yalovaya,Larisa Kolomiets,Aleksei Shefer,Alina Grigor'eva,Alexey Tupikin,Irina Kondakova,Svetlana Tamkovich

Molecules (Basel, Switzerland) 26: PubMed34834058

2021

Plasma Exosomes of Patients with Breast and Ovarian Tumors Contain an Inactive 20S Proteasome.

Applications

Unspecified application

Species

Unspecified reactive species

Natalia Yunusova,Elena Kolegova,Elena Sereda,Larisa Kolomiets,Alisa Villert,Marina Patysheva,Irina Rekeda,Alina Grigor'eva,Natalia Tarabanovskaya,Irina Kondakova,Svetlana Tamkovich

iScience 24:103421 PubMed34877488

2021

A nonhuman primate model of vertical sleeve gastrectomy facilitates mechanistic and translational research in human obesity.

Applications

Unspecified application

Species

Unspecified reactive species

Julia L Nugent,Amar Singh,Keith M Wirth,Scott Hunter Oppler,Laura Hocum Stone,Jody L Janecek,Adam C Sheka,Scott Kizy,Meghan E G Moore,Christopher Staley,Bernhard J Hering,Sabarinathan Ramachandran,Sayeed Ikramuddin,Melanie L Graham

Asian Pacific journal of cancer prevention : APJCP 22:861-869 PubMed33773551

2021

Exosomal Protease Cargo as Prognostic Biomarker in Colorectal Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Natalia V Yunusova,Elena A Zambalova,Marina R Patysheva,Elena S Kolegova,Sergey G Afanas'ev,Olga V Cheremisina,Alina E Grigor'eva,Svetlana N Tamkovich,Irina V Kondakova

International journal of molecular sciences 20: PubMed31614781

2019

Renal Artery Stenosis Alters Gene Expression in Swine Scattered Tubular-Like Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Arash Aghajani Nargesi,Xiang-Yang Zhu,Yuanhang Liu,Hui Tang,Kyra L Jordan,Lilach O Lerman,Alfonso Eirin

American journal of physiology. Renal physiology 317:F1142-F1153 PubMed31461348

2019

Renovascular disease induces mitochondrial damage in swine scattered tubular cells.

Applications

Unspecified application

Species

Unspecified reactive species

Arash Aghajani Nargesi,Xiang-Yang Zhu,Sabena M Conley,John R Woollard,Ishran M Saadiq,Lilach O Lerman,Alfonso Eirin

Asian Pacific journal of cancer prevention : APJCP 20:809-815 PubMed30909692

2019

Relation between Tetraspanin- Associated and Tetraspanin- Non- Associated Exosomal Proteases and Metabolic Syndrome in Colorectal Cancer Patients

Applications

Unspecified application

Species

Unspecified reactive species

Elena A Tugutova,Svetlana N Tamkovich,Marina R Patysheva,Sergey G Afanas’ev,Anastasia A Tsydenova,Alina E Grigor’eva,Elena S Kolegova,Irina V Kondakova,Natalia V Yunusova

Clinica chimica acta; international journal of cli 494:116-122 PubMed30904547

2019

Metalloproteinases at the surface of small extrcellular vesicles in advanced ovarian cancer: Relationships with ascites volume and peritoneal canceromatosis index.

Applications

Unspecified application

Species

Unspecified reactive species

Natalia V Yunusova,Marina R Patysheva,Sergey V Molchanov,Elena A Zambalova,Alina E Grigor'eva,Larisa A Kolomiets,Maxim O Ochirov,Svetlana N Tamkovich,Irina V Kondakova

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CD24 antibody [SN3]

Flow Cytometry - Anti-CD24 antibody [SN3] (AB134375)

Flow Cytometry - Anti-CD24 antibody [SN3] (AB134375)

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Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

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Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (12)

Product promise