Anti-CD300 antibody

Target data

Acts as an inhibitory receptor for myeloid cells and mast cells (PubMed : 17438331). Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells (PubMed : 21865548). Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (PubMed : 26768664). Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide which acts as a ligand (PubMed : 23123064). May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling (PubMed : 26124135). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2 (By similarity). Inhibits osteoclast formation (PubMed : 14662855). Induces macrophage cell death upon engagement (PubMed : 18097021).. (Microbial infection) Acts as a functional receptor for murine norovirus (MNV). Mediates binding to the cell surface and is both necessary and sufficient for viral entry and replication (PubMed : 27540007, PubMed : 27681626, PubMed : 30194229). This interaction requires Mg(2+) and Ca(2+) and is enhanced by bile acids (PubMed : 30194229). Primary determinant of MNV species tropism and is sufficient to render cells permissive to infection by MNV. Can render nonmurine mammalian cells susceptible to MNV infection (PubMed : 27540007, PubMed : 27681626).