Rabbit Monoclonal CD31 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 6 publications.
Images
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD31 antibody [SP38] (AB231436), expandable thumbnail](https://content.abcam.com/products/images/cd31-antibody-sp38-ab231436--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img25740.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD31 antibody [SP38] (AB231436)")
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD31 antibody [SP38] (AB231436), expandable thumbnail](https://content.abcam.com/products/images/cd31-antibody-sp38-ab231436--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img6706.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD31 antibody [SP38] (AB231436)")
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD31 antibody [SP38] (AB231436), expandable thumbnail](https://content.abcam.com/products/images/cd31-antibody-sp38-ab231436--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img77018.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD31 antibody [SP38] (AB231436)")
Publications
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- Journal of clinical medicine 12:2023Pilot Study: FSHR Expression in Neuroendocrine Tumors of the Appendix.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDariusz Starzyński,Sylwia Rzeszotek,Agnieszka Kolasa,Marta Grabowska,Barbara Wiszniewska,Aleksandra Kudrymska,Katarzyna Karpińska,Aleksandra Tołoczko-Grabarek,Agnieszka Janiec,Aleksandra Myszka,Paweł Rynio,Anhelli Syrenicz,Elżbieta Sowińska-PrzepieraPubMed 37568488
- Methods in molecular biology (Clifton, N.J.) 2442:685-7112022Exploring the Role of Galectins in Cancer : In Vitro and In Vivo Approaches.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNeus Martínez-Bosch,Noemí Manero-Rupérez,Mireia Moreno,Pilar NavarroPubMed 35320553
- Journal of autoimmunity 56:23-332014Upholding the T cell immune-regulatory function of CD31 inhibits the formation of T/B immunological synapses in vitro and attenuates the development of experimental autoimmune arthritis in vivo.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMarc Clement,Giulia Fornasa,Stéphane Loyau,Marion Morvan,Francesco Andreata,Kevin Guedj,Jamila Khallou-Laschet,Paola Larghi,Delphine Le Roux,Georges Bismuth,Gilles Chiocchia,Claire Hivroz,Debra K Newman,Antonino Nicoletti,Giuseppina CaligiuriPubMed 25277651
- Clinical cancer research : an official journal of the American Association for Cancer Research 20:938-502013Targeting epithelial-to-mesenchymal transition with Met inhibitors reverts chemoresistance in small cell lung cancer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesIsrael Cañadas,Federico Rojo,Álvaro Taus,Oriol Arpí,Montserrat Arumí-Uría,Lara Pijuan,Silvia Menéndez,Sandra Zazo,Manuel Dómine,Marta Salido,Sergi Mojal,Antonio García de Herreros,Ana Rovira,Joan Albanell,Edurne ArriolaPubMed 24284055
- BMC cancer 13:2132013VEGF is an important mediator of tumor angiogenesis in malignant lesions in a genetically engineered mouse model of lung adenocarcinoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesBharat K Majeti et. al.PubMed 23627488
- PloS one 8:e553192013Human embryonic stem cell-derived mesenchymal stroma cells (hES-MSCs) engraft in vivo and support hematopoiesis without suppressing immune function: implications for off-the shelf ES-MSC therapies.Applications:Unspecified applicationReactive species:Unspecified reactive speciesOu Li et. al.PubMed 23383153
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.5
Preservative: 0.1% Sodium azide
Constituents: Tissue culture supernatant, Tris buffered saline, 1% BSA- Form
- Liquid
- Clonality
- Monoclonal
Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
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Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
| Mouse | Predicted |
| Rat | Predicted |
| Pig | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/50 | Notes Boil tissue section in citrate buffer, pH 6.0 for 10 minutes followed by cooling at room temperature for 20 min. Incubate with ab231436 for 10 minutes at room temperature. The ideal fixation time will depend on the size of the tissue block and the type of tissue, but fixation between 18–24h is suitable for most samples. Positive Control: Hu tonsil tissue |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat, Pig | Dilution info - | Notes - |
Associated Products
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Target data
Function
Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:17580308, PubMed:19342684). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed:27958302). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892). Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896). Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed:18672896). Induces susceptibility to atherosclerosis (By similarity). Isoform Delta15. Does not protect against apoptosis.
Alternative names
CD31, Platelet endothelial cell adhesion molecule, PECAM-1, EndoCAM, GPIIA', PECA1, PECAM1
Recommended products
Rabbit Monoclonal CD31 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 6 publications.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.5
Preservative: 0.1% Sodium azide
Constituents: Tissue culture supernatant, Tris buffered saline, 1% BSA- Form
- Liquid
- Clonality
- Monoclonal
- Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
- Clone number
- SP38
- Purity
- Tissue culture supernatant
- Concentration
- Purification notes
Purified from TCS.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
3 product images
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD31 antibody [SP38] (ab231436), expandable thumbnail](https://content.abcam.com/products/images/cd31-antibody-sp38-ab231436--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img25740.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD31 antibody [SP38] (ab231436)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD31 antibody [SP38] (ab231436)
Formalin-fixed, paraffin-embedded human endometrium tissue stained for CD31 using ab231436 at 1/50 dilution in immunohistochemical analysis.
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD31 antibody [SP38] (ab231436), expandable thumbnail](https://content.abcam.com/products/images/cd31-antibody-sp38-ab231436--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img6706.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD31 antibody [SP38] (ab231436)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD31 antibody [SP38] (ab231436)
Formalin-fixed, paraffin-embedded human heart tissue stained for CD31 using ab231436 at 1/50 dilution in immunohistochemical analysis.
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD31 antibody [SP38] (ab231436), expandable thumbnail](https://content.abcam.com/products/images/cd31-antibody-sp38-ab231436--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img77018.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD31 antibody [SP38] (ab231436)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD31 antibody [SP38] (ab231436)
Formalin-fixed, paraffin-embedded human colon adenocarcinoma tissue stained for CD31 using ab231436 at 1/50 dilution in immunohistochemical analysis.
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