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AB231436

Anti-CD31 antibody [SP38]

5

(5 Reviews)

|

(7 Publications)

Rabbit Recombinant Monoclonal CD31 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 7 publications.

View Alternative Names

CD31, Platelet endothelial cell adhesion molecule, PECAM-1, EndoCAM, GPIIA', PECA1, PECAM1

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD31 antibody [SP38] (AB231436)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD31 antibody [SP38] (AB231436)

Formalin-fixed, paraffin-embedded human heart tissue stained for CD31 using ab231436 at 1/50 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD31 antibody [SP38] (AB231436)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD31 antibody [SP38] (AB231436)

Formalin-fixed, paraffin-embedded human colon adenocarcinoma tissue stained for CD31 using ab231436 at 1/50 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD31 antibody [SP38] (AB231436)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD31 antibody [SP38] (AB231436)

Formalin-fixed, paraffin-embedded human endometrium tissue stained for CD31 using ab231436 at 1/50 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

SP38

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50", "IHCP-species-notes": "<p>Boil tissue section in citrate buffer, pH 6.0 for 10 minutes followed by cooling at room temperature for 20 min. Incubate with ab231436 for 10 minutes at room temperature.</p><p>The ideal fixation time will depend on the size of the tissue block and the type of tissue, but fixation between 18–24h is suitable for most samples.</p><p>Positive Control: Hu tonsil tissue</p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purity
Tissue culture supernatant
Purification notes
Purified from TCS.
Storage buffer
pH: 7.5 Preservative: 0.1% Sodium azide Constituents: Tissue culture supernatant, Tris buffered saline, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed : 17580308, PubMed : 19342684). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed : 19342684). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed : 27958302). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed : 17580308). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed : 12110892). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed : 12110892). Modulates bradykinin receptor BDKRB2 activation (PubMed : 18672896). Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed : 18672896). Induces susceptibility to atherosclerosis (By similarity).. Isoform Delta15. Does not protect against apoptosis.
See full target information PECAM1
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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

World journal of gastrointestinal oncology 17:105264 PubMed40697228

2025

Nav1.6 drives colorectal cancer proliferation and invasion through MAPK signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Li-Ming Zhao,Wan-Ying Hong,Jian-Guang Xu,Shui-Quan Lin,Ming-Sheng Liu,Li-Hui Wang,Xu-Li Jiang,Ming Sang,Yang-Bo Lv

Journal of clinical medicine 12: PubMed37568488

2023

Pilot Study: FSHR Expression in Neuroendocrine Tumors of the Appendix.

Applications

Unspecified application

Species

Unspecified reactive species

Dariusz Starzyński,Sylwia Rzeszotek,Agnieszka Kolasa,Marta Grabowska,Barbara Wiszniewska,Aleksandra Kudrymska,Katarzyna Karpińska,Aleksandra Tołoczko-Grabarek,Agnieszka Janiec,Aleksandra Myszka,Paweł Rynio,Anhelli Syrenicz,Elżbieta Sowińska-Przepiera

Methods in molecular biology (Clifton, N.J.) 2442:685-711 PubMed35320553

2022

Exploring the Role of Galectins in Cancer : In Vitro and In Vivo Approaches.

Applications

Unspecified application

Species

Unspecified reactive species

Neus Martínez-Bosch,Noemí Manero-Rupérez,Mireia Moreno,Pilar Navarro

Journal of autoimmunity 56:23-33 PubMed25277651

2014

Upholding the T cell immune-regulatory function of CD31 inhibits the formation of T/B immunological synapses in vitro and attenuates the development of experimental autoimmune arthritis in vivo.

Applications

Unspecified application

Species

Unspecified reactive species

Marc Clement,Giulia Fornasa,Stéphane Loyau,Marion Morvan,Francesco Andreata,Kevin Guedj,Jamila Khallou-Laschet,Paola Larghi,Delphine Le Roux,Georges Bismuth,Gilles Chiocchia,Claire Hivroz,Debra K Newman,Antonino Nicoletti,Giuseppina Caligiuri

Clinical cancer research : an official journal of the American Association for Cancer Research 20:938-50 PubMed24284055

2013

Targeting epithelial-to-mesenchymal transition with Met inhibitors reverts chemoresistance in small cell lung cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Israel Cañadas,Federico Rojo,Álvaro Taus,Oriol Arpí,Montserrat Arumí-Uría,Lara Pijuan,Silvia Menéndez,Sandra Zazo,Manuel Dómine,Marta Salido,Sergi Mojal,Antonio García de Herreros,Ana Rovira,Joan Albanell,Edurne Arriola

BMC cancer 13:213 PubMed23627488

2013

VEGF is an important mediator of tumor angiogenesis in malignant lesions in a genetically engineered mouse model of lung adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Bharat K Majeti,Joseph H Lee,Brett H Simmons,Farbod Shojaei

PloS one 8:e55319 PubMed23383153

2013

Human embryonic stem cell-derived mesenchymal stroma cells (hES-MSCs) engraft in vivo and support hematopoiesis without suppressing immune function: implications for off-the shelf ES-MSC therapies.

Applications

Unspecified application

Species

Unspecified reactive species

Ou Li,Ariane Tormin,Berit Sundberg,Johan Hyllner,Katarina Le Blanc,Stefan Scheding
View all publications
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