AB212311

Anti-CD35 antibody [CR1/802] - BSA and Azide free

Name: Anti-CD35 antibody [CR1/802] - BSA and Azide free (ab212311) | Abcam
Brand: Abcam Limited
SKU: AB212311
Price: 905 USD
Availability: InStock

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(1 Publication)

Mouse Monoclonal CD35 antibody. Carrier free. Suitable for IHC-P and reacts with Human, Baboon samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CR1.

View Alternative Names

CD35, C3BR, CR1, Complement receptor type 1, C3b/C4b receptor

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD35 antibody [CR1/802] - BSA and Azide free (AB212311)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD35 antibody [CR1/802] - BSA and Azide free (AB212311)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human tonsil tissue labeling CD35 with ab212311 at 1 μg/ml.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

CR1/802

Isotype

IgG1

Light chain type

kappa

Carrier free

Yes

Reacts with

Human, Baboon

Applications

IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human CR1.

P17927

Specificity

ab212311 is highly specific to CD35 (CR1) and shows no cross-reaction with CD21 (CR2). ab212311 does not block CD35 (CR1) activity.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "0.5-1 µg/mL", "IHCP-species-notes": "<p>(Primary incubation for 30 minutes at RT).</p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Baboon": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "0.5-1 µg/mL", "IHCP-species-notes": "<p>(Primary incubation for 30 minutes at RT).</p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Purification notes

ab212311 was purified from Bioreactor Concentrate by Protein A/G.

Storage buffer

pH: 7.2 - 7.4 Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages (PubMed : 2963069). Mediates the binding by these cells of particles and immune complexes that have activated complement to eliminate them from the circulation (PubMed : 2963069). Acts also in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d (PubMed : 2972794, PubMed : 8175757). Also plays a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells (PubMed : 25742728).. (Microbial infection) Acts as a receptor for Epstein-Barr virus.

See full target information CR1

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 20: PubMed31035427

2019

Mapping Semaphorins and Netrins in the Pathogenesis of Human Thoracic Aortic Aneurysms.

Applications

Unspecified application

Species

Unspecified reactive species

Dornazsadat Alebrahim,Mangala Nayak,Alison Ward,Patricia Ursomanno,Rebecca Shams,Annanina Corsica,Rayan Sleiman,Kissinger Hyppolite Fils,Michele Silvestro,Ludovic Boytard,Tarik Hadi,Bruce Gelb,Bhama Ramkhelawon

View all publications

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