Rabbit Recombinant Monoclonal CD41 antibody. Suitable for WB, IHC-P and reacts with Mouse, Rat samples. Cited in 5 publications.
Images
![Western blot - Anti-CD41 antibody [EPR17876] (AB181582), expandable thumbnail](https://content.abcam.com/products/images/cd41-antibody-epr17876-ab181582--western-blot-img88371.jpg/_jcr_content/renditions/webp-475.webp "Western blot - Anti-CD41 antibody [EPR17876] (AB181582)")
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD41 antibody [EPR17876] (AB181582), expandable thumbnail](https://content.abcam.com/products/images/cd41-antibody-epr17876-ab181582--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img96839.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD41 antibody [EPR17876] (AB181582)")
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD41 antibody [EPR17876] (AB181582), expandable thumbnail](https://content.abcam.com/products/images/cd41-antibody-epr17876-ab181582--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img82791.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD41 antibody [EPR17876] (AB181582)")
Publications
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- Cell death discovery 9:1162023Counteracting gemcitabine+nab-paclitaxel induced dysbiosis in KRAS wild type and KRAS mutated pancreatic cancer in vivo model.Applications:Unspecified applicationReactive species:Unspecified reactive speciesConcetta Panebianco,Federica Pisati,Annacandida Villani,Annapaola Andolfo,Marynka Ulaszewska,Edoardo Bellini,Carmelapia Ferro,Renato Lombardi,Fabrizio Orsenigo,Tiziana Pia Latiano,Beatrice Belmonte,Claudio Tripodo,Francesco Perri,Valerio PazienzaPubMed 37019893
- iScience 25:1039432022A murine model of cerebral cavernous malformations with acute hemorrhage.Applications:Unspecified applicationReactive species:Unspecified reactive speciesClaudio Maderna,Federica Pisati,Claudio Tripodo,Elisabetta Dejana,Matteo MalinvernoPubMed 35265815
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology 35:e218182021Platelet and myeloid cell phenotypes in a rat model of Fabry disease.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAdam J Kanack,Kazuhiro Aoki,Michael Tiemeyer,Nancy M DahmsPubMed 34320241
- Scientific reports 11:65802021TMAO: a potential mediator of clopidogrel resistance.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRuisong Ma,Wenwen Fu,Jing Zhang,Xiaorong Hu,Jun Yang,Hong JiangPubMed 33753834
- Theranostics 11:2278-22962021A blood circulation-prolonging peptide anchored biomimetic phage-platelet hybrid nanoparticle system for prolonged blood circulation and optimized anti-bacterial performance.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPeipei Jin et. al.PubMed 33500725
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.01% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA- Form
- Liquid
- Clonality
- Monoclonal
Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
Reactivity data
Select an application| WB | IHC-P | ICC/IF | |
|---|---|---|---|
| Mouse | Tested | Tested | Not recommended |
| Rat | Tested | Tested | Not recommended |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/1000 | Notes Perform heat-mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol. |
Species Rat | Dilution info 1/1000 | Notes Perform heat-mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol. |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/500 | Notes Perform heat-mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol. |
Species Rat | Dilution info 1/500 | Notes Perform heat-mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol. |
ICC/IF
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
Associated Products
Select an associated product type
15 products for Alternative Product
Target data
Function
Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
Alternative names
CD41, Integrin alpha-IIb, GPalpha IIb, Platelet membrane glycoprotein IIb, GPIIb, Itga2b
Recommended products
Rabbit Recombinant Monoclonal CD41 antibody. Suitable for WB, IHC-P and reacts with Mouse, Rat samples. Cited in 5 publications.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.01% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA- Form
- Liquid
- Clonality
- Monoclonal
- Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
- Clone number
- EPR17876
- Purification technique
- Affinity purification Protein A
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free batch production
For more information, read more on recombinant antibodies.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
3 product images
![Western blot - Anti-CD41 antibody [EPR17876] (ab181582), expandable thumbnail](https://content.abcam.com/products/images/cd41-antibody-epr17876-ab181582--western-blot-img88371.jpg "Western blot - Anti-CD41 antibody [EPR17876] (ab181582)")
Western blot - Anti-CD41 antibody [EPR17876] (ab181582)
Blocking/Dilution: 5% NFDM/TBST
Exposure: Lanes 1, 3, 4: 3 minutes; lane 2: 10 seconds; Lane 5: 1 minute.
All lanes: Western blot - Anti-CD41 antibody [EPR17876] (ab181582) at 1/1000 dilution
Lane 1: Rat platelet lysate at 20 µg
Lane 2: Mouse platelet lysate at 20 µg
Lane 3: Mouse lung tissue lysate at 20 µg
Lane 4: Mouse spleen tissue lysate at 20 µg
Lane 5: Rat spleen tissue lysate at 20 µg
SecondaryLanes 1 - 2: Western blot - Goat Anti-Rabbit IgG H&L (HRP) (Goat Anti-Rabbit IgG H&L (HRP) ab97051) at 1/100000 dilution
Lanes 3 - 5: Western blot - Goat Anti-Rabbit IgG H&L (HRP) (Goat Anti-Rabbit IgG H&L (HRP) ab97051) at 1/20000 dilution
Developed using the ECL technique.
Predicted band size: 113 kDa
Observed band size: 113 kDa
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD41 antibody [EPR17876] (ab181582), expandable thumbnail](https://content.abcam.com/products/images/cd41-antibody-epr17876-ab181582--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img96839.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD41 antibody [EPR17876] (ab181582)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD41 antibody [EPR17876] (ab181582)
Immunohistochemical analysis of paraffin-embedded mouse spleen tissue labeling CD41 with ab181582 at 1/500 dilution, followed by Goat Anti-Rabbit IgG H&L (HRP), ready to use. Cytoplasmic staining on megakaryocytes and thrombocytes of mouse spleen (PMID: 28133558). Counter stained with Hematoxylin.
Secondary antibody only control: Used PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG H&L (HRP), ready to use.
Antigen Retrieval was heat mediated using 0.01M Tris-EDTA, pH 9.0 or 0.01M Sodium Citrate Buffer, pH 6.0.
Perform heat mediated antigen retrieval with EDTA buffer pH 9 before commencing with IHC staining protocol.
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD41 antibody [EPR17876] (ab181582), expandable thumbnail](https://content.abcam.com/products/images/cd41-antibody-epr17876-ab181582--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img82791.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD41 antibody [EPR17876] (ab181582)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD41 antibody [EPR17876] (ab181582)
Immunohistochemical analysis of paraffin-embedded rat spleen tissue labeling CD41 with ab181582 at 1/500 dilution, followed by Goat Anti-Rabbit IgG H&L (HRP), ready to use. Cytoplasmic staining on megakaryocytes and thrombocytes of rat spleen (PMID: 28133558). Counter stained with Hematoxylin.
Secondary antibody only control: Used PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG H&L (HRP), ready to use.
Antigen Retrieval was heat mediated using 0.01M Tris-EDTA, pH 9.0 or 0.01M Sodium Citrate Buffer, pH 6.0.
Perform heat mediated antigen retrieval with EDTA buffer pH 9 before commencing with IHC staining protocol.
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