AB15021

Anti-CD41 antibody [HIP8]

Name: Anti-CD41 antibody [HIP8] (ab15021) | Abcam
Brand: Abcam Limited
SKU: AB15021
Price: 520 USD
Availability: InStock

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(3 Publications)

Mouse Monoclonal CD41 antibody. Suitable for Flow Cyt and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human ITGA2B.

View Alternative Names

CD41, GP2B, ITGAB, ITGA2B, Integrin alpha-IIb, GPalpha IIb, Platelet membrane glycoprotein IIb, GPIIb

1 Images

Flow Cytometry - Anti-CD41 antibody [HIP8] (AB15021)

Flow Cyt

Lab

Flow Cytometry - Anti-CD41 antibody [HIP8] (AB15021)

Flow cytometry analysis staining CD41 in human peripheral blood cells using ab15021.

387 mFluor™ UV375

mFluor™ UV375 Anti-CD41 antibody [HIP8]
454 mFluor™ Violet 450

mFluor™ Violet 450 Anti-CD41 antibody [HIP8]

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

HIP8

Isotype

IgG1

Carrier free

Reacts with

Human

Applications

Flow Cyt

applications

Immunogen

Native Full Length Protein corresponding to Human ITGA2B.

P08514

Specificity

Ab15021 reconizes the GPIIb-alpha (heavy chain) of CD41. The CD41/CD61 complex is a receptor for fibronectin, fibrinogen, von Willebrand factor, vitronectin and thrombospondin and mediates platelets aggregation. Ab15021 [HIP8] blocks platelet aggregation and completely inhibits ADP, epinephrine, and collagen-induced platelet activation, and partially inhibits ristocetin and thrombin-induced platelet activation.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1-4 µg/mL", "FlowCyt-species-notes": "<p><a href='/en-us/products/primary-antibodies/mouse-igg1-kappa-monoclonal-15-6e10a7-isotype-control-ab170190'>ab170190</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Storage buffer

pH: 7.4 Preservative: 0.097% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Integrin alpha-IIb/beta-3 (ITGA2B : ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain (By similarity). Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen (PubMed : 9111081). This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface (By similarity). Integrin ITGA2B : ITGB3 is also the receptor of erythrocyte-specific ICAM4 ligand involved in heterotypic cell-cell adhesion between erythrocytes and activated platelets (PubMed : 12477717).

See full target information ITGA2B

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Cell 171:1368-1382.e23 PubMed29195076

2017

Migrating Platelets Are Mechano-scavengers that Collect and Bundle Bacteria.

Applications

Unspecified application

Species

Unspecified reactive species

Florian Gaertner,Zerkah Ahmad,Gerhild Rosenberger,Shuxia Fan,Leo Nicolai,Benjamin Busch,Gökce Yavuz,Manja Luckner,Hellen Ishikawa-Ankerhold,Roman Hennel,Alexandre Benechet,Michael Lorenz,Sue Chandraratne,Irene Schubert,Sebastian Helmer,Bianca Striednig,Konstantin Stark,Marek Janko,Ralph T Böttcher,Admar Verschoor,Catherine Leon,Christian Gachet,Thomas Gudermann,Michael Mederos Y Schnitzler,Zachary Pincus,Matteo Iannacone,Rainer Haas,Gerhard Wanner,Kirsten Lauber,Michael Sixt,Steffen Massberg

Nature protocols 5:1337-46 PubMed20595961

2010

Optimized multiparametric immunophenotyping of umbilical cord blood cells by flow cytometry.

Applications

Unspecified application

Species

Unspecified reactive species

Christina Basford,Nico Forraz,Colin McGuckin

International journal of stem cells 3:32-45 PubMed24855539

2010

The cord blood separation league table: a comparison of the major clinical grade harvesting techniques for cord blood stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Christina Basford,Nicolas Forraz,Saba Habibollah,Kendal Hanger,Colin McGuckin

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CD41 antibody [HIP8]

Flow Cytometry - Anti-CD41 antibody [HIP8] (AB15021)

Related conjugates and formulations (2)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Publications (3)

Product promise