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AB33661

Anti-CD41 antibody [MWReg30]

5

(9 Reviews)

|

(29 Publications)

Rat Monoclonal CD41 antibody. Suitable for Flow Cyt and reacts with Mouse samples. Cited in 29 publications.

View Alternative Names

CD41, Integrin alpha-IIb, GPalpha IIb, Platelet membrane glycoprotein IIb, GPIIb, Itga2b

  • 578 PE

    PE Anti-CD41 antibody [MWReg30]

  • 660 APC

    APC Anti-CD41 antibody [MWReg30]

  • 778 PE/Cy7®

    PE/Cy7® Anti-CD41 antibody [MWReg30]

Key facts

Host species

Rat

Clonality

Monoclonal

Clone number

MWReg30

Isotype

IgG1

Carrier free

No

Reacts with

Mouse

Applications

Flow Cyt

applications

Specificity

ab33661 recognizes integrin alpha IIb subunit CD41

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "1/50 - 1/100", "FlowCyt-species-notes": "<p>Use 10μl of the suggested working dilution to label 10<sup>6</sup> cells in 100μl.</p>" } } }
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Product details

The azide free version is ab94960.

Clone MWReg30 has been reported to inhibit PMA induced aggregation in vitro and to induce hypothermia in vivo.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Storage buffer
pH: 7.4 Preservative: 0.09% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
See full target information Itga2b
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Publications (29)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 13:11392 PubMed37452090

2023

SARS-CoV-2 spike protein induces lung endothelial cell dysfunction and thrombo-inflammation depending on the C3a/C3a receptor signalling.

Applications

Unspecified application

Species

Unspecified reactive species

Luca Perico,Marina Morigi,Anna Pezzotta,Monica Locatelli,Barbara Imberti,Daniela Corna,Domenico Cerullo,Ariela Benigni,Giuseppe Remuzzi

International journal of biological sciences 19:3614-3627 PubMed37496998

2023

The role of CREG1 in megakaryocyte maturation and thrombocytopoiesis.

Applications

Unspecified application

Species

Unspecified reactive species

HaiXu Song,Jiayin Li,Chengfei Peng,Dan Liu,Zhu Mei,Zheming Yang,Xiaoxiang Tian,Xiaolin Zhang,Quanmin Jing,Chenghui Yan,Yaling Han

Nature communications 14:3122 PubMed37264009

2023

Vagus nerve stimulation primes platelets and reduces bleeding in hemophilia A male mice.

Applications

Unspecified application

Species

Unspecified reactive species

Carlos E Bravo-Iñiguez,Jason R Fritz,Shilpa Shukla,Susmita Sarangi,Dane A Thompson,Seema G Amin,Tea Tsaava,Saher Chaudhry,Sara P Valentino,Hannah B Hoffman,Catherine W Imossi,Meghan E Addorisio,Sergio I Valdes-Ferrer,Sangeeta S Chavan,Lionel Blanc,Christopher J Czura,Kevin J Tracey,Jared M Huston

Cancer research 83:1299-1314 PubMed36652557

2023

Active Remodeling of Capillary Endothelium via Cancer Cell-Derived MMP9 Promotes Metastatic Brain Colonization.

Applications

Unspecified application

Species

Unspecified reactive species

Matthia A Karreman,Alexander T Bauer,Gergely Solecki,Anna S Berghoff,Chanté D Mayer,Katharina Frey,Nils Hebach,Manuel J Feinauer,Nicole L Schieber,Cedric Tehranian,Luc Mercier,Mahak Singhal,Varun Venkataramani,Marc C Schubert,Daniel Hinze,Michael Hölzel,Iris Helfrich,Dirk Schadendorf,Stefan W Schneider,Dana Westphal,Hellmut G Augustin,Jacky G Goetz,Yannick Schwab,Wolfgang Wick,Frank Winkler

Methods and protocols 5: PubMed36136817

2022

Single and Multiplex Immunohistochemistry to Detect Platelets and Neutrophils in Rat and Porcine Tissues.

Applications

Unspecified application

Species

Unspecified reactive species

Stephanie Arnold,Sarah Watts,Emrys Kirkman,Clive P Page,Simon C Pitchford

Reproductive sciences (Thousand Oaks, Calif.) 29:1170-1187 PubMed35099777

2022

Tetramethylpyrazine Retards the Progression and Fibrogenesis of Endometriosis.

Applications

Unspecified application

Species

Unspecified reactive species

Shenghui Huang,Fengyi Xiao,Sun-Wei Guo,Tingting Zhang

Cell death & disease 12:955 PubMed34657146

2021

Essential role of zyxin in platelet biogenesis and glycoprotein Ib-IX surface expression.

Applications

Unspecified application

Species

Unspecified reactive species

Rong Yan,Xinxin Ge,Ningbo Pang,Honglei Ye,Liuxia Yuan,Bin Cheng,Kangxi Zhou,Mengnan Yang,Yueyue Sun,Suqin Zhang,Zhongren Ding,Jincai Luo,Changgeng Ruan,Kesheng Dai

Scientific reports 11:10885 PubMed34035344

2021

Analysis of glucose metabolism by F-FDG-PET imaging and glucose transporter expression in a mouse model of intracerebral hemorrhage.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoning Han,Honglei Ren,Ayon Nandi,Xuanjia Fan,Raymond C Koehler

Cancer research 81:2373-2385 PubMed33687949

2021

Platelet TLR4-ERK5 Axis Facilitates NET-Mediated Capturing of Circulating Tumor Cells and Distant Metastasis after Surgical Stress.

Applications

Unspecified application

Species

Unspecified reactive species

Jinghua Ren,Jiayi He,Hongji Zhang,Yujia Xia,Zhiwei Hu,Patricia Loughran,Timothy Billiar,Hai Huang,Allan Tsung

JACC. Basic to translational science 5:1017-1028 PubMed33145464

2020

Proteolysis of Von Willebrand Factor Influences Inflammatory Endothelial Activation and Vascular Compliance in Atherosclerosis.

Applications

Unspecified application

Species

Unspecified reactive species

Koya Ozawa,Matthew A Muller,Oleg Varlamov,Hagai Tavori,William Packwood,Paul A Mueller,Aris Xie,Zaverio Ruggeri,Dominic Chung,José A López,Jonathan R Lindner
View all publications
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Product promise

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