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AB34229

Anti-CD44v3 antibody [VFF-327]

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(4 Publications)

Mouse Monoclonal CD44 antibody. Suitable for Flow Cyt, IHC-P, IHC-Fr and reacts with Human samples. Cited in 4 publications.

View Alternative Names

CD44, LHR, MDU2, MDU3, MIC4, CD44 antigen, CDw44, Epican, Extracellular matrix receptor III, GP90 lymphocyte homing/adhesion receptor, HUTCH-I, Heparan sulfate proteoglycan, Hermes antigen, Hyaluronate receptor, Phagocytic glycoprotein 1, Phagocytic glycoprotein I, ECMR-III, PGP-1, PGP-I

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

VFF-327

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

Flow Cyt, IHC-Fr, IHC-P

applications

Specificity

This antibody specifically recognises an epitope encoded by exon V3 on the variant portion of human CD44

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "10 µL for 10^6 Cells", "FlowCyt-species-notes": "<p><a href='/en-us/products/primary-antibodies/mouse-igg1-kappa-monoclonal-15-6e10a7-isotype-control-ab170190'>ab170190</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p><p>Use 10μl (at a concentration of 10 μg/ml) for 10<sup>6</sup> cells in 100μl.</p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "10 µg/mL", "IHCP-species-notes": "<p></p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "10 µg/mL", "IHCFr-species-notes": "<p></p>" } } }

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
Preservative: 0.09% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Target data

The protein expressed by gene CD44 functions as a cell-surface receptor involved in cell-cell interactions, cell adhesion, and migration, allowing cells to detect and react to changes in their tissue microenvironment. It is implicated in numerous cellular processes, including the activation, recirculation, and homing of T-lymphocytes, hematopoiesis, inflammation, and the response to bacterial infection. Through its ectodomain, CD44 interacts with extracellular matrix components like hyaluronan, collagen, growth factors, cytokines, and proteases, serving as a platform for signal transduction by forming protein complexes with receptor kinases and membrane proteases via its cytoplasmic domain. Effectors such as PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases, and phospholipase C coordinate signaling pathways that promote calcium mobilization and actin-mediated cytoskeleton reorganization crucial for cell migration and adhesion. This supplementary information is collated from multiple sources and compiled automatically.
See full target information CD44

Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Translational cancer research 9:1215-1224 PubMed35117466

2020

Clinicopathological significance and prognostic implication of CD44 and its splice variants (v3 and v6) in colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Bing Yan,Ying Mu,Meiqi Cui,Long Liu

Molecular oncology 13:1993-2009 PubMed31294922

2019

Elevated N-methyltransferase expression induced by hepatic stellate cells contributes to the metastasis of hepatocellular carcinoma via regulation of the CD44v3 isoform.

Applications

Unspecified application

Species

Unspecified reactive species

Jie Li,Song You,Sheng Zhang,Qing Hu,Fuqiang Wang,Xiaoqin Chi,Wenxiu Zhao,Chengrong Xie,Changmao Zhang,Yaqi Yu,Jianmin Liu,Yue Zhao,Pingguo Liu,Yi Zhang,Xujin Wei,Qiu Li,Xiaomin Wang,Zhenyu Yin

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 52:1083-90 PubMed15258184

2004

Differential expression of CD44 during human prostate epithelial cell differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Tahirah N Alam,Michael J O'Hare,István Laczkó,Alex Freeman,Farah Al-Beidh,John R Masters,David L Hudson

The Journal of investigative dermatology 113:11-21 PubMed10417612

1999

Mitigation of delayed-type hypersensitivity reactions by a CD44 variant isoform v3-specific antibody: blockade of leukocyte egress.

Applications

Unspecified application

Species

Unspecified reactive species

S Seiter,P Engel,N Föhr,M Zöller
View all publications

Product promise

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