Anti-CD45 antibody [IBL-3/16]
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(1 Review)
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(27 Publications)
Anti-CD45 antibody [IBL-3/16] (ab23910) is a rat monoclonal antibody detecting CD45 in Flow Cytometry, IP, IHC-Fr, ICC/IF. Suitable for Mouse.
- Over 20 publications
- Trusted since 2005
View Alternative Names
CD45, Ly-5, Ptprc, Receptor-type tyrosine-protein phosphatase C, Leukocyte common antigen, Lymphocyte antigen 5, T200, L-CA
Reactivity data
Product details
Anti-CD45 antibody [IBL-3/16] (ab23910) is a rat monoclonal antibody and is validated for use in Flow Cytometry (Flow Cyt), Immunoprecipitation (IP), Immunohistochemistry (IHC-Fr), Immunocytochemistry/immunofluorescence (ICC/IF) in Mouse samples.
Trusted by the scientific community
Anti-CD45 [IBL-3/16] (ab23910) was first used in a scientific publication in 2005 and has been cited over 20 times in peer-reviewed journals.
Properties and storage information
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Purification notes
Storage buffer
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
CD45 acts by regulating tyrosine phosphorylation in the immune cell signaling context participating directly in signal transduction. It functions by dephosphorylating specific phosphotyrosine residues on various proteins modulating the signaling threshold required for lymphocyte activation. Although not known to be part of a protein complex CD45 itself shows isoform variation that associates with specific immune cell types impacting their function. Importantly CD45 interacts with multiple signaling molecules to affect cell growth and differentiation.
Pathways
Scientists associate CD45 with signaling pathways such as the T-cell receptor (TCR) and B-cell receptor (BCR) signaling. CD45 modulates the activity of Src family kinases important elements in these pathways making it essential for effective immune response and tolerance. Furthermore interactions between CD45 and proteins like Lck in T-cells or Lyn in B-cells highlight its pivotal role in executing its signaling functions.
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Target data
Publications (27)
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PloS one 20:e0328001 PubMed40844997
2025
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Stem cell research & therapy 16:218 PubMed40312745
2025
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Journal of extracellular vesicles 14:e70038 PubMed39868462
2025
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Respiratory research 25:6 PubMed38178133
2024
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Nature 623:792-802 PubMed37968392
2023
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Advanced materials (Deerfield Beach, Fla.) 35:e2302801 PubMed37589156
2023
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Frontiers in cellular neuroscience 17:1192464 PubMed37377777
2023
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BMC veterinary research 19:64 PubMed36997964
2023
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Nature metabolism 4:995-1006 PubMed35902645
2022
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Frontiers in immunology 13:853769 PubMed35572508
2022
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Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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