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AB34070

Anti-CD5 antibody [CC17]

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(1 Publication)

Mouse Monoclonal CD5 antibody. Suitable for Flow Cyt and reacts with Cow samples. Cited in 1 publication. Immunogen corresponding to Cell preparation containing CD5 protein.

View Alternative Names

CD5, T-cell surface glycoprotein CD5

1 Images
Flow Cytometry - Anti-CD5 antibody [CC17] (AB34070)
  • Flow Cyt

Supplier Data

Flow Cytometry - Anti-CD5 antibody [CC17] (AB34070)

Staining of bovine peripheral blood lymphocytes with Mouse anti Bovine CD5.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

CC17

Isotype

IgG1

Carrier free

No

Reacts with

Cow

Applications

Flow Cyt

applications

Immunogen

Cell preparation containing CD5 protein. The exact immunogen used to generate this antibody is proprietary information.

P19238

Specificity

ab34070 is specific for bovine CD5. This clone reacts with BoCD5.1, which is a polymorphic antigen expressed on cells of all Bos Taurus animals and a small proportion of Bos Indicus animals.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Cow": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "10 µL for 10^6 Cells", "FlowCyt-species-notes": "<p><a href='/en-us/products/primary-antibodies/mouse-igg1-kappa-monoclonal-15-6e10a7-isotype-control-ab170190'>ab170190</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
Preservative: 0.09% Sodium azide
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD5 also known as T1 or Leu-1 is a glycoprotein with a molecular mass of approximately 67 kDa. It is expressed mainly on the surface of T cells and a subset of B cells. CD5 plays a major role in the regulation of immune responses. It functions by modulating T-cell receptor (TCR) signaling often acting as a negative regulator to prevent excessive immune activation. Researchers often utilize CD5 antibodies such as those conjugated with PerCP for immunohistochemistry (IHC) to study this protein's expression and distribution.
Biological function summary

CD5 is essential in the immune system's ability to maintain tolerance to self-antigens thereby preventing autoimmune responses. CD5 forms part of a receptor complex on the cell surface that interacts with ligands and other receptors to fine-tune immune cell signaling. Its localization and function in T cells relate closely to its ability to modulate signaling pathways essential for cell survival and proliferation. This modulation is important for ensuring that immune responses are appropriate to the stimuli encountered.

Pathways

CD5 is involved in signal transduction processes important for immune tolerance and modulation. It intersects with pathways like the T cell receptor (TCR) signaling pathway and the NF-kB signaling pathway. These pathways involve interaction with proteins like Zap70 a tyrosine kinase related to TCR signaling and the downstream activation of transcription factors that regulate immune responses. The protein CRIS1 also appears in some pathway interactions highlighting the interconnected nature of immune regulatory proteins.

CD5 has significant associations with autoimmune diseases such as systemic lupus erythematosus (SLE) where its modulatory role can affect autoantibody production. Additionally CD5 in conjunction with proteins like OX19 correlates with certain lymphoproliferative disorders including chronic lymphocytic leukemia (CLL). In these disorders the expression and function of CD5 may impact disease progression and patient response to therapy making it a potential target for intervention in immune-related conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May act as a receptor in regulating T-cell proliferation.
See full target information CD5
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Veterinary immunology and immunopathology 19:127-39 PubMed3055661

1988

Two monoclonal antibodies (CC17, CC29) recognizing an antigen (Bo5) on bovine T lymphocytes, analogous to human CD5.

Applications

Unspecified application

Species

Unspecified reactive species

C J Howard,K R Parsons,B V Jones,P Sopp,D H Pocock
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