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Mouse Monoclonal CD5 antibody. Suitable for Flow Cyt and reacts with Cow samples. Cited in 1 publication. Immunogen corresponding to Cell preparation containing CD5 protein.

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Images

Flow Cytometry - Anti-CD5 antibody [CC17] (AB34070), expandable thumbnail

Publications

Key facts

Isotype

IgG1

Host species

Mouse

Storage buffer

Preservative: 0.09% Sodium azide

Form

Liquid

Clonality

Monoclonal

Immunogen

  • Cell preparation containing CD5 protein. The exact immunogen used to generate this antibody is proprietary information. Database link P19238

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
Flow Cyt
Cow
Tested

Tested
Tested

Species

Cow

Dilution info

10 µL for 106 Cells

Notes

ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

Associated Products

Select an associated product type

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Target data

Function

May act as a receptor in regulating T-cell proliferation.

Alternative names

Recommended products

Mouse Monoclonal CD5 antibody. Suitable for Flow Cyt and reacts with Cow samples. Cited in 1 publication. Immunogen corresponding to Cell preparation containing CD5 protein.

Key facts

Isotype

IgG1

Form

Liquid

Clonality

Monoclonal

Immunogen
  • Cell preparation containing CD5 protein. The exact immunogen used to generate this antibody is proprietary information. Database link P19238
Clone number

CC17

Purification technique

Affinity purification Protein G

Specificity

ab34070 is specific for bovine CD5. This clone reacts with BoCD5.1, which is a polymorphic antigen expressed on cells of all Bos Taurus animals and a small proportion of Bos Indicus animals.

Concentration
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Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

CD5 also known as T1 or Leu-1 is a glycoprotein with a molecular mass of approximately 67 kDa. It is expressed mainly on the surface of T cells and a subset of B cells. CD5 plays a major role in the regulation of immune responses. It functions by modulating T-cell receptor (TCR) signaling often acting as a negative regulator to prevent excessive immune activation. Researchers often utilize CD5 antibodies such as those conjugated with PerCP for immunohistochemistry (IHC) to study this protein's expression and distribution.

Biological function summary

CD5 is essential in the immune system's ability to maintain tolerance to self-antigens thereby preventing autoimmune responses. CD5 forms part of a receptor complex on the cell surface that interacts with ligands and other receptors to fine-tune immune cell signaling. Its localization and function in T cells relate closely to its ability to modulate signaling pathways essential for cell survival and proliferation. This modulation is important for ensuring that immune responses are appropriate to the stimuli encountered.

Pathways

CD5 is involved in signal transduction processes important for immune tolerance and modulation. It intersects with pathways like the T cell receptor (TCR) signaling pathway and the NF-kB signaling pathway. These pathways involve interaction with proteins like Zap70 a tyrosine kinase related to TCR signaling and the downstream activation of transcription factors that regulate immune responses. The protein CRIS1 also appears in some pathway interactions highlighting the interconnected nature of immune regulatory proteins.

Associated diseases and disorders

CD5 has significant associations with autoimmune diseases such as systemic lupus erythematosus (SLE) where its modulatory role can affect autoantibody production. Additionally CD5 in conjunction with proteins like OX19 correlates with certain lymphoproliferative disorders including chronic lymphocytic leukemia (CLL). In these disorders the expression and function of CD5 may impact disease progression and patient response to therapy making it a potential target for intervention in immune-related conditions.

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1 product image

  • Flow Cytometry - Anti-CD5 antibody [CC17] (ab34070), expandable thumbnail

    Flow Cytometry - Anti-CD5 antibody [CC17] (ab34070)

    Staining of bovine peripheral blood lymphocytes with Mouse anti Bovine CD5.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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