Mouse Monoclonal CD5 antibody. Suitable for Flow Cyt and reacts with Cow samples. Cited in 1 publication. Immunogen corresponding to Cell preparation containing CD5 protein.
IgG1
Mouse
Preservative: 0.09% Sodium azide
Liquid
Monoclonal
Flow Cyt | |
---|---|
Cow | Tested |
Species | Dilution info | Notes |
---|---|---|
Species Cow | Dilution info 10 µL for 106 Cells | Notes ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
Select an associated product type
May act as a receptor in regulating T-cell proliferation.
T-cell surface glycoprotein CD5
Mouse Monoclonal CD5 antibody. Suitable for Flow Cyt and reacts with Cow samples. Cited in 1 publication. Immunogen corresponding to Cell preparation containing CD5 protein.
IgG1
Mouse
Preservative: 0.09% Sodium azide
Liquid
Monoclonal
CC17
Affinity purification Protein G
ab34070 is specific for bovine CD5. This clone reacts with BoCD5.1, which is a polymorphic antigen expressed on cells of all Bos Taurus animals and a small proportion of Bos Indicus animals.
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
CD5 also known as T1 or Leu-1 is a glycoprotein with a molecular mass of approximately 67 kDa. It is expressed mainly on the surface of T cells and a subset of B cells. CD5 plays a major role in the regulation of immune responses. It functions by modulating T-cell receptor (TCR) signaling often acting as a negative regulator to prevent excessive immune activation. Researchers often utilize CD5 antibodies such as those conjugated with PerCP for immunohistochemistry (IHC) to study this protein's expression and distribution.
CD5 is essential in the immune system's ability to maintain tolerance to self-antigens thereby preventing autoimmune responses. CD5 forms part of a receptor complex on the cell surface that interacts with ligands and other receptors to fine-tune immune cell signaling. Its localization and function in T cells relate closely to its ability to modulate signaling pathways essential for cell survival and proliferation. This modulation is important for ensuring that immune responses are appropriate to the stimuli encountered.
CD5 is involved in signal transduction processes important for immune tolerance and modulation. It intersects with pathways like the T cell receptor (TCR) signaling pathway and the NF-kB signaling pathway. These pathways involve interaction with proteins like Zap70 a tyrosine kinase related to TCR signaling and the downstream activation of transcription factors that regulate immune responses. The protein CRIS1 also appears in some pathway interactions highlighting the interconnected nature of immune regulatory proteins.
CD5 has significant associations with autoimmune diseases such as systemic lupus erythematosus (SLE) where its modulatory role can affect autoantibody production. Additionally CD5 in conjunction with proteins like OX19 correlates with certain lymphoproliferative disorders including chronic lymphocytic leukemia (CLL). In these disorders the expression and function of CD5 may impact disease progression and patient response to therapy making it a potential target for intervention in immune-related conditions.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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Staining of bovine peripheral blood lymphocytes with Mouse anti Bovine CD5.
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