Mouse Monoclonal CD57 antibody. Suitable for Flow Cyt, IHC-P, IHC-Fr and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Cell preparation containing CD57 protein.
View Alternative Names
HKN1, LEU7
Reactivity data
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Supplementary information
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Biological function summary
CD57 plays a role in immune regulation and cell-mediated cytotoxicity. CD57+ cells which are often mature or post-activation states in NK cells and T lymphocytes are less proliferative but have enhanced cytotoxic abilities. These cells contribute to the immune surveillance against viral infections and tumor cells. CD57 does not belong to any well-known protein complexes but can cooperate with other surface markers to modulate immune functions.
Pathways
CD57+ cell populations participate in the immune system pathways related to cell-mediated immunity and cytotoxic response. The presence of CD57 is often associated with the downregulation of proliferative pathways and the enhancement of cytotoxic pathways. It shows functional overlap with proteins such as CD16 and NKG2D which also play roles in mediating the cytotoxic activity of NK cells.
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Target data
Publications (2)
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British journal of cancer 131:258-270 PubMed38834745
2024
Applications
Unspecified application
Species
Unspecified reactive species
Journal of leukocyte biology 76:667-75 PubMed15178706
2004
Applications
Unspecified application
Species
Unspecified reactive species
Product promise
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