Anti-CD59 antibody [MEM-43]
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(2 Reviews)
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(25 Publications)
Anti-CD59 antibody [MEM-43] (ab9182) is a mouse monoclonal antibody detecting CD59 in Western Blot, Flow Cytometry, IP, IHC-P, IHC-Fr, ICC/IF. Suitable for Human.
- Over 20 publications
- Trusted since 2002
View Alternative Names
CD59, MIC11, MIN1, MIN2, MIN3, MSK21, CD59 glycoprotein, 1F5 antigen, 20 kDa homologous restriction factor, MAC-inhibitory protein, MEM43 antigen, Membrane attack complex inhibition factor, Membrane inhibitor of reactive lysis, Protectin, HRF-20, HRF20, MAC-IP, MACIF, MIRL
- Flow Cyt
Supplier Data
Flow Cytometry - Anti-CD59 antibody [MEM-43] (AB9182)
Flow cytometric analysis of Human Peripheral Blood cells labelling CD59 with ab9182 at 0.3 ug/ml showing separation of human neutrophil granulocytes (red-filled) from human CD59 negative blood debris (black-dashed).
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD59 antibody [MEM-43] (AB9182)
Immunohistochemistry parafin embedded sections staining of huam palacenta tissue using ab9182 with a concentration of 10μg / ml
Related conjugates and formulations (5)
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Biotin Anti-CD59 antibody [MEM-43]
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660 APC
APC Anti-CD59 antibody [MEM-43]
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578 PE
PE Anti-CD59 antibody [MEM-43]
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519 FITC
FITC Anti-CD59 antibody [MEM-43]
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665 Alexa Fluor® 647
Alexa Fluor® 647 Anti-CD59 antibody [MEM-43]
Reactivity data
Product details
Anti-CD59 antibody [MEM-43] (ab9182) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Flow Cyt), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), Immunohistochemistry (IHC-Fr), Immunocytochemistry/immunofluorescence (ICC/IF) in Human samples.
What is the molecular weight of CD59?
Anti-CD59 [MEM-43] (ab9182) specifically detects a band for CD59 (UniProt: P13987) at a molecular weight of 14kDa.
Trusted by the scientific community
Anti-CD59 [MEM-43] (ab9182) was first used in a scientific publication in 2002 and has been cited over 20 times in peer-reviewed journals.
Other related products
We have a range of other formats of antibody clone [MEM-43] also available for your convenience: ab9182, FITC - ab18237, Biotin - ab28114, PE - ab36421, APC - ab36467, Alexa Fluor® 647 - ab187769
Properties and storage information
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Aliquoting information
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Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
One important feature of CD59 is its role as a glycosylphosphatidylinositol (GPI)-anchored protein involved in safeguarding cells from complement-mediated damage. It does not exist within a larger complex but functions at the cell surface to inhibit the assembly of complement components C5b-9 which form the MAC. This ability to inhibit MAC is essential in maintaining self-tissue from unintended damage during immune responses.
Pathways
CD59 participates in the regulation of the complement cascade specifically within the terminal pathway. The complement system serves as a bridge between innate and adaptive immunity contributing to processes like opsonization and cell lysis. CD59's inhibitory action directly impacts pathways that utilize terminal components such as C5b. Effective CD59 function prevents excessive complement activation ensuring that an immune response does not damage host tissues. It links closely with other complement regulatory proteins like CD55 which also mitigate complement cascade activation.
Product protocols
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Target data
Publications (25)
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Brain sciences 14: PubMed38928601
2024
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International journal of molecular sciences 23: PubMed35563599
2022
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American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 22:46-57 PubMed34331749
2021
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Cellular and molecular life sciences : CMLS 78:3637-3656 PubMed33555391
2021
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BioMed research international 2020:2753414 PubMed32337233
2020
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Journal of Cancer 10:4165-4177 PubMed31413735
2019
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Journal of cellular and molecular medicine 23:5956-5969 PubMed31293077
2019
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Cell 177:1738-1756.e23 PubMed31104842
2019
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Oncology letters 15:9061-9068 PubMed29805637
2018
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Oncology letters 14:2961-2969 PubMed28928834
2017
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Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com