AB2497

Anti-CD62E antibody [UZ6]

Name: Anti-CD62E antibody [UZ6] (ab2497) | Abcam
Brand: Abcam Limited
SKU: AB2497
Rating: 4 (1 reviews)

(1 Review)

(9 Publications)

Rat Monoclonal CD62E antibody. Suitable for ICC/IF and reacts with Mouse samples. Cited in 9 publications.

View Alternative Names

CD62E, ELAM1, SELE, E-selectin, CD62 antigen-like family member E, Endothelial leukocyte adhesion molecule 1, Leukocyte-endothelial cell adhesion molecule 2, ELAM-1, LECAM2

1 Images

Immunocytochemistry/ Immunofluorescence - Anti-CD62E antibody [UZ6] (AB2497)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-CD62E antibody [UZ6] (AB2497)

CHO-cells transfected with E-Selectin stained wtih ab2497 at 1/500.

Key facts

Host species

Rat

Clonality

Monoclonal

Clone number

UZ6

Isotype

IgG2b

Carrier free

Reacts with

Mouse

Applications

ICC/IF

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

Preservative: 0.09% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD62E also known as E-selectin or ELAM-1 is a cell adhesion molecule with a mass of approximately 115 kDa. It is present mainly on endothelial cells activated by cytokines. As a transmembrane glycoprotein E-selectin plays a mechanical role in mediating the tethering and rolling of leukocytes on the vascular endothelium during the inflammatory response. This function is important in directing leukocytes to sites of tissue damage or infection.

Biological function summary

E-selectin facilitates leukocyte adhesion by binding specific carbohydrate ligands on the surface of circulating immune cells. This binding is critical in the cascade of events that leads to leukocyte extravasation into tissues. E-selectin does not work in isolation rather forming part of a complex interaction with other cell adhesion molecules such as P-selectin and L-selectin. These interactions ensure precise control of cellular traffic during inflammatory responses.

Pathways

CD62E engages in the inflammatory signaling pathways including the NF-kB pathway. This pathway modulates the expression of E-selectin in response to pro-inflammatory cytokines like interleukin-1 and tumor necrosis factor-alpha. CD62E interacts with integrins on leukocytes and has downstream effects on cellular processes involved in immune response. Its cooperation with proteins like ICAM-1 and VCAM-1 further integrates it into a network of adhesion molecules maintaining vascular stability and immune surveillance.

E-selectin expression is highly relevant in inflammatory diseases such as rheumatoid arthritis and atherosclerosis. These disorders involve chronic inflammation where the persistent activation of endothelial cells and overexpression of E-selectin contribute to pathology. The link with ICAM-1 in these settings suggests a mutual regulation between cell adhesion molecules enhancing leukocyte recruitment to inflamed tissues. This makes E-selectin not only a marker of endothelial activation but also a potential therapeutic target for modulating leukocyte adhesion in inflammatory diseases.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis.

See full target information SELE

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Publications (9)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in immunology 16:1447319 PubMed40124367

2025

Heme oxygenase-1 modulates CD62E-dependent endothelial cell-monocyte interactions and mitigates HLA-I-induced transplant vasculopathy in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Laura Schuster,Marcin Zaradzki,Henrike Janssen,Nadia Gallenstein,Melanie Etheredge,Ilse Hofmann,Markus A Weigand,Stephan Immenschuh,Jan Larmann

EMBO molecular medicine 17:504-534 PubMed39962271

2025

Repression of apelin Furin cleavage sites provides antimetastatic strategy in colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Béatrice Demoures,Fabienne Soulet,Jean Descarpentrie,Isabel Galeano-Otero,José Sanchez Collado,Maria Casado,Tarik Smani,Alvaro González,Isabel Alves,Fabrice Lalloué,Bernard Masri,Estelle Rascol,Jean-William Dupuy,Cyril Dourthe,Frédéric Saltel,Anne-Aurélie Raymond,Iker Badiola,Serge Evrard,Bruno Villoutreix,Simon Pernot,Géraldine Siegfried,Abdel-Majid Khatib

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11:e2404661 PubMed39364760

2024

The eATP/P2×7R Axis Drives Quantum Dot-Nanoparticle Induced Neutrophil Recruitment in the Pulmonary Microcirculation.

Applications

Unspecified application

Species

Unspecified reactive species

Chenxi Li,Qiongliang Liu,Lianyong Han,Haiyun Zhang,Roland Immler,Birgit Rathkolb,Judith Secklehner,Martin Hrabe de Angelis,Ali Önder Yildirim,Dagmar Zeuschner,Annette Nicke,Leo M Carlin,Markus Sperandio,Tobias Stoeger,Markus Rehberg

Communications biology 4:1165 PubMed34621018

2021

Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock.

Applications

Unspecified application

Species

Unspecified reactive species

Takeharu Sakamoto,Yuya Fukui,Yasumitsu Kondoh,Kaori Honda,Takeshi Shimizu,Toshiro Hara,Tetsuro Hayashi,Yurika Saitoh,Yoshinori Murakami,Jun-Ichiro Inoue,Shuichi Kaneko,Hiroyuki Osada,Motoharu Seiki

Journal of molecular and cellular cardiology 150:91-100 PubMed33127387

2020

Combined high-throughput library screening and next generation RNA sequencing uncover microRNAs controlling human cardiac fibroblast biology.

Applications

Unspecified application

Species

Unspecified reactive species

Katharina Schimmel,Stevan D Stojanović,Cheng-Kai Huang,Mira Jung,Martin H Meyer,Ke Xiao,Lea Grote-Levi,Christian Bär,Angelika Pfanne,Saskia Mitzka,Annette Just,Robert Geffers,Katharina Bock,Franziska Kenneweg,Felix Kleemiß,Christine S Falk,Jan Fiedler,Thomas Thum

Annals of palliative medicine 9:2079-2089 PubMed32692224

2020

The protective effect of vitexinin septic encephalopathy by reducing leukocyte-endothelial adhesion and inflammatory response.

Applications

Unspecified application

Species

Unspecified reactive species

Haiquan Cao,Xiaojuan Wang,Bing Zhang,Meiping Ren

Journal of cellular biochemistry 120:115-125 PubMed30206961

2018

Effects of RNA interference-mediated E-selectin gene silencing on cell adhesion molecule expression and cell-cell adhesion in vascular endothelial cells in mice with immunologic contact urticaria.

Applications

Unspecified application

Species

Unspecified reactive species

Zu-Dong Meng,Xiao-Lan Wang,Tian-Ping Du,Yu Wang,Gui-Fang Qin,Hong-Bo Zhao,Yu-Jie Chen,Bo Tian

Science translational medicine 3:69ra12 PubMed21307302

2011

5-Lipoxygenase metabolite 4-HDHA is a mediator of the antiangiogenic effect of ω-3 polyunsaturated fatty acids.

Applications

Unspecified application

Species

Unspecified reactive species

Przemyslaw Sapieha,Andreas Stahl,Jing Chen,Molly R Seaward,Keirnan L Willett,Nathan M Krah,Roberta J Dennison,Kip M Connor,Christopher M Aderman,Elvira Liclican,Arianna Carughi,Dalia Perelman,Yoshihide Kanaoka,John Paul Sangiovanni,Karsten Gronert,Lois E H Smith

Experimental cell research 269:266-74 PubMed11570819

2001

Species-specific and conserved epitopes on mouse and human E-selectin important for leukocyte adhesion.

Applications

Unspecified application

Species

Unspecified reactive species

M Hammel,G Weitz-Schmidt,A Krause,T Moll,D Vestweber,H G Zerwes,R Hallmann

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CD62E antibody [UZ6]

Immunocytochemistry/ Immunofluorescence - Anti-CD62E antibody [UZ6] (AB2497)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (9)

Product promise