Anti-CD68 antibody [C68/684] (ab201340) is a mouse monoclonal antibody detecting CD68 in Western Blot, Flow Cytometry, IHC-P, ICC/IF. Suitable for Human.
- Over 100 publications
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CD68, Macrosialin, Gp110
- IHC-P
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD68 antibody [C68/684] (AB201340)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human tonsil tissue labeling CD68 with ab201340 at 1 μg/ml.
- Flow Cyt
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Flow Cytometry - Anti-CD68 antibody [C68/684] (AB201340)
Flow Cytometry analysis of U-87 MG (human glioblastoma-astrocytoma epithelial cell line) cells labeling CD68 with ab201340. Goat Anti-Mouse IgG was used as the secondary antibody (blue); Isotype Control (red).
- ICC/IF
Supplier Data
Immunocytochemistry/ Immunofluorescence - Anti-CD68 antibody [C68/684] (AB201340)
Immunocytochemistry/immunofluorescence analysis of U-87 MG (human glioblastoma-astrocytoma epithelial cell line) cells labelling CD68 with ab201340. Goat Anti-Mouse IgG was used as the secondary antibody (green). Nuclear DNA stained red.
- WB
Supplier Data
Western blot - Anti-CD68 antibody [C68/684] (AB201340)
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Western blot - Anti-CD68 antibody [C68/684] (ab201340)
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Human spleen tissue lysate
Predicted band size: 37 kDa
Observed band size: 110 kDa
false
Reactivity data
Product details
Anti-CD68 antibody [C68/684] (ab201340) has been cited over 105 times in peer reviewed journals and is trusted by the scientific community.
Abcams high quality validation processes ensure Anti-CD68 antibody [C68/684] (ab201340) has high sensitivity and specificity.
Anti-CD68 antibody [C68/684] (ab201340) specifically detects CD68 (UniProt ID: P34810; Molecular weight: 35kDa) and is sold in 100 uL selling sizes.
Conjugation-ready, carrier free format available for antibody clone C68/684 - ab21398.
CD68 is a marker primarily associated with macrophages, playing a crucial role in phagocytosis, antigen presentation, and immune response regulation. CD68 is a biomarker in chronic inflammatory conditions including rheumatoid arthritis and inflammatory bowel disease
ab201340 stains macrophages in a wide variety of Human tissues, including Kupffer cells and macrophages in the red pulp of the spleen, in lamina propria of the gut, in lung alveoli, and in bone marrow. It reacts with myeloid precursors and peripheral blood granulocytes. It also reacts with plasmacytoid T cells, which are supposed to be of monocyte/macrophage origin. It shows strong granular cytoplasmic staining of chronic and acute myeloid leukemia and also reacts with rare cases of true histiocytic neoplasia. Lymphomas are negative or show few granules.
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Supplementary information
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Biological function summary
CD68 facilitates functions associated with the innate immune response. It serves as an important part of macrophages which contribute to immune surveillance and tissue homeostasis. Though it primarily operates on its own in some contexts CD68 might assist in forming complexes with other receptors to modulate phagocytic activity. This target is significant in atherosclerotic plaque stability as macrophages engulf lipids and cell debris through processes facilitated by CD68.
Pathways
CD68 is involved in pathways connected to inflammation and phagocytosis. The CD68 protein works closely with other scavenger receptors like CD36 to mediate uptake of oxidized low-density lipoproteins (oxLDL) in the lipid metabolism pathway. Additionally CD68 engagement can influence the toll-like receptor (TLR) signaling pathways thereby linking innate immunity and inflammatory responses critical for host defense and disease progression.
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Publications (149)
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Mediators of inflammation 2025:4932970 PubMed40918406
2025
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Journal of translational medicine 23:923 PubMed40826409
2025
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Regenerative biomaterials 12:rbaf062 PubMed40708704
2025
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Frontiers in cell and developmental biology 13:1592594 PubMed40607212
2025
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Nature communications 16:3705 PubMed40251193
2025
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Nature communications 16:3283 PubMed40189598
2025
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Bone research 13:26 PubMed39994205
2025
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Cell reports. Medicine 6:101932 PubMed39879993
2025
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International journal of ophthalmology 18:15-27 PubMed39829614
2025
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Nature communications 16:52 PubMed39746939
2025
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Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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