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AB783

Anti-CD68 antibody [PG-M1]

5

(2 Reviews)

|

(25 Publications)

Anti-CD68 antibody [PG-M1] (ab783) is a mouse monoclonal antibody detecting CD68 in IHC-P. Suitable for Human.

- Over 10 publications
- Trusted since 2002

View Alternative Names

CD68, Macrosialin, Gp110

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD68 antibody [PG-M1] (AB783)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD68 antibody [PG-M1] (AB783)

ab783 staining CD68 in Human tonsil tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD68 antibody [PG-M1] (AB783)
  • IHC-P

AbReview11485****

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD68 antibody [PG-M1] (AB783)

Paraformaldehyde-fixed, paraffin-embedded human granulomatous inflammatory tissue stained for CD68 using ab783 in immunohistochemical analysis.

This image is courtesy of an anonymous Abreview.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

PG-M1

Isotype

IgG3

Light chain type

kappa

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

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Reactivity data

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Product details

Product Specifications
Anti-CD68 antibody [PG-M1] (ab783) is a mouse monoclonal antibody and is validated for use in IHC-P in human samples.
Anti-CD68 antibody [PG-M1] (ab783) specifically detects CD68 (UniProt ID: P34810; Molecular weight: 35kDa) and is sold in 500 µL selling sizes.

Quality and Validation
Abcam's high quality validation processes ensure Anti-CD68 antibody [PG-M1] (ab783) has high sensitivity and specificity.
Anti-CD68 antibody [PG-M1] (ab783) has been cited over 18 times in peer reviewed journals and is trusted by the scientific community.
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Properties and storage information

Form
Liquid
Purity
Tissue culture supernatant
Storage buffer
pH: 7.3 - 7.5 Preservative: 0.05% Sodium azide Constituents: 98.95% Tissue culture supernatant, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD68 is a glycoprotein that functions as a scavenger receptor. It plays an important role in the regulation of cellular debris and apoptotic cell clearance. Researchers often refer to it as KP1 or macrosialin in the literature. CD68 with a molecular weight of approximately 110 kDa is highly expressed in macrophages and monocytes. The mucin-like structure of CD68 allows it to be heavily glycosylated which aids in its function. Researchers detect CD68 in tissues through methods like immunohistochemistry (IHC) immunofluorescence and CD68 staining and it is widely used as a macrophage marker in research.
Biological function summary

CD68 facilitates functions associated with the innate immune response. It serves as an important part of macrophages which contribute to immune surveillance and tissue homeostasis. Though it primarily operates on its own in some contexts CD68 might assist in forming complexes with other receptors to modulate phagocytic activity. This target is significant in atherosclerotic plaque stability as macrophages engulf lipids and cell debris through processes facilitated by CD68.

Pathways

CD68 is involved in pathways connected to inflammation and phagocytosis. The CD68 protein works closely with other scavenger receptors like CD36 to mediate uptake of oxidized low-density lipoproteins (oxLDL) in the lipid metabolism pathway. Additionally CD68 engagement can influence the toll-like receptor (TLR) signaling pathways thereby linking innate immunity and inflammatory responses critical for host defense and disease progression.

CD68 is associated with atherosclerosis and multiple sclerosis. In atherosclerosis its role becomes evident as it accumulates in macrophages within the plaques making it a marker of disease severity. In multiple sclerosis CD68 expression in macrophages and microglia indicates active demyelination and inflammation. It also relates to proteins such as CD36 in atherosclerosis where both mediate the uptake of modified LDL contributing to foam cell formation in plaques.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
See full target information CD68
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Publications (25)

Recent publications for all applications. Explore the full list and refine your search

Acta neuropathologica communications 13:39 PubMed39985110

2025

Neuronal TDP-43 aggregation drives changes in microglial morphology prior to immunophenotype in amyotrophic lateral sclerosis.

Applications

Unspecified application

Species

Unspecified reactive species

Molly E V Swanson,Miran Mrkela,Clinton Turner,Maurice A Curtis,Richard L M Faull,Adam K Walker,Emma L Scotter

The Journal of pathology 265:226-243 PubMed39703181

2024

Characterisation of GPR17-expressing oligodendrocyte precursors in human ischaemic lesions and correlation with reactive glial responses.

Applications

Unspecified application

Species

Unspecified reactive species

Stefano Raffaele,Bettina Hjelm Clausen,Francesca Carolina Mannella,Martin Wirenfeldt,Davide Marangon,Sarah Boe Tidgen,Silvia Corradini,Kirsten Madsen,Davide Lecca,Maria Pia Abbracchio,Kate Lykke Lambertsen,Marta Fumagalli

Science advances 10:eadp0684 PubMed39413197

2024

Semaphorin 3D promotes pancreatic ductal adenocarcinoma progression and metastasis through macrophage reprogramming.

Applications

Unspecified application

Species

Unspecified reactive species

Noelle R J Thielman,Vanessa Funes,Sanjana Davuluri,Hector E Ibanez,Wei-Chih Sun,Juan Fu,Keyu Li,Stephen Muth,Xingyi Pan,Kenji Fujiwara, Dwayne L Thomas Ii,MacKenzie Henderson,Selina Shiqing Teh,Qingfeng Zhu,Elizabeth Thompson,Elizabeth M Jaffee,Alex Kolodkin,Fengxi Meng,Lei Zheng

Nature 628:612-619 PubMed38509366

2024

Venous-plexus-associated lymphoid hubs support meningeal humoral immunity.

Applications

Unspecified application

Species

Unspecified reactive species

Zachary Fitzpatrick,Nagela Ghabdan Zanluqui,Jared S Rosenblum,Zewen Kelvin Tuong,Colin Y C Lee,Vikram Chandrashekhar,Maria Luciana Negro-Demontel,Andrew P Stewart,David A Posner,Monica Buckley,Kieren S J Allinson,Panagiotis Mastorakos,Prashant Chittiboina,Dragan Maric,Danielle Donahue,Adel Helmy,Tamara Tajsic,John R Ferdinand,Anais Portet,Ana Peñalver,Eleanor Gillman,Zhengping Zhuang,Menna R Clatworthy,Dorian B McGavern

International journal of molecular sciences 24: PubMed37894936

2023

Adipocytes in the Uterine Wall during Experimental Healing and in Cesarean Scars during Pregnancy.

Applications

Unspecified application

Species

Unspecified reactive species

Natalia Tikhonova,Andrey P Milovanov,Valentina V Aleksankina,Ilyas A Kulikov,Tatiana V Fokina,Andrey P Aleksankin,Tamara N Belousova,Ludmila M Mikhaleva,Natalya V Niziaeva

Cell reports 42:112773 PubMed37393623

2023

Distinct myeloid population phenotypes dependent on TREM2 expression levels shape the pathology of traumatic versus demyelinating CNS disorders.

Applications

Unspecified application

Species

Unspecified reactive species

Han Gao,Jiawei Di,Bettina Hjelm Clausen,Nanxiang Wang,Xizhong Zhu,Tianlun Zhao,Yanyu Chang,Mao Pang,Yang Yang,Ronghan He,Yuge Wang,Liangming Zhang,Bin Liu,Wei Qiu,Kate Lykke Lambertsen,Roberta Brambilla,Limin Rong

Acta neuropathologica communications 11:69 PubMed37118836

2023

Microglial CD68 and L-ferritin upregulation in response to phosphorylated-TDP-43 pathology in the amyotrophic lateral sclerosis brain.

Applications

Unspecified application

Species

Unspecified reactive species

Molly E V Swanson,Miran Mrkela,Helen C Murray,Maize C Cao,Clinton Turner,Maurice A Curtis,Richard L M Faull,Adam K Walker,Emma L Scotter

Biology 11: PubMed35741460

2022

The Inflammatory Response after Moderate Contusion Spinal Cord Injury: A Time Study.

Applications

Unspecified application

Species

Unspecified reactive species

Minna Christiansen Lund,Ditte Gry Ellman,Maiken Nissen,Pernille Sveistrup Nielsen,Pernille Vinther Nielsen,Carina Jørgensen,Ditte Caroline Andersen,Han Gao,Roberta Brambilla,Matilda Degn,Bettina Hjelm Clausen,Kate Lykke Lambertsen

Biomedicines 10: PubMed35625908

2022

Gasdermin D Deficiency Limits the Transition of Atherosclerotic Plaques to an Inflammatory Phenotype in Knock-Out Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Pauline Puylaert,Melissa Van Praet,Frederik Vaes,Cédric H G Neutel,Lynn Roth,Pieter-Jan Guns,Guido R Y De Meyer,Wim Martinet

Frontiers in immunology 13:874255 PubMed35663986

2022

Deciphering the Immune Complexity in Esophageal Adenocarcinoma and Pre-Cancerous Lesions With Sequential Multiplex Immunohistochemistry and Sparse Subspace Clustering Approach.

Applications

Unspecified application

Species

Unspecified reactive species

Srinand Sundaram,Eun Na Kim,Georgina M Jones,Shamilene Sivagnanam,Monika Tripathi,Ahmad Miremadi,Massimiliano Di Pietro,Lisa M Coussens,Rebecca C Fitzgerald,Young Hwan Chang,Lizhe Zhuang
View all publications
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