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AB202843

Anti-CD72 antibody - N-terminal

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(1 Publication)

Rabbit Polyclonal CD72 antibody. N-terminal. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human CD72 aa 1-50 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

CD72, B-cell differentiation antigen CD72, Lyb-2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD72 antibody - N-terminal (AB202843)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD72 antibody - N-terminal (AB202843)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human gastric carcinoma tissue labeling CD72 with ab202843 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD72 antibody - N-terminal (AB202843)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD72 antibody - N-terminal (AB202843)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human cervical carcinoma tissue labeling CD72 with ab202843 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human CD72 aa 1-50 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P21854

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p>When using a fluorescent probe the recommended dilution is 1/50 – 1/200.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD72 also known as Lyb-2 is a membrane protein with a molecular weight of approximately 45-50 kDa. It is part of the C-type lectin family and expresses mainly on B cells. CD72 serves as a receptor and recognizes ligands to mediate cell signaling. The protein is also present in some myeloid cells contributing to its diverse roles in the immune system. The function of CD72 involves the modulation of B cell receptor (BCR) signaling which is important for B cell development and activation.
Biological function summary

CD72 functions as a regulatory protein that influences B cell activity by modulating BCR signaling thresholds. CD72 is part of receptor-ligand complexes on the B cell surface. It operates alongside other proteins like CD5 and SHP-1 to fine-tune immune responses. By interacting with these proteins CD72 helps in maintaining immune balance and prevents overactivation that can lead to autoimmune reactions. This protein modulates both positive and negative signaling affecting B cell survival and differentiation.

Pathways

CD72 influences immune response pathways specifically the BCR signaling pathway and the downstream PI3K-Akt pathway. As a negative regulator CD72 works in tandem with proteins such as Lyn and SHP-1 to attenuate BCR signal transduction. These signaling cascades play a role in immune responses lymphocyte development and adaptation. The involvement of CD72 in these pathways illustrates its function in balancing the intensity of signals received by B cells ultimately affecting immune response outcomes.

CD72 dysregulation has been linked to systemic lupus erythematosus (SLE) and certain lymphomas. Abnormal expression or function of CD72 can lead to improper B cell activation contributing to autoimmune conditions like SLE. In these diseases CD72 interaction with proteins such as SHP-1 and CD22 becomes disrupted affecting immune tolerance and promoting pathological immune responses. Additionally altered CD72 expression or mutations have been observed in B cell malignancies indicating its role in the pathology of these disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Co-receptor of B cell receptor (BCR) that plays both positive and negative roles on B-cell functions. Recognizes the Sm/ribonucleoprotein (RNP) self-antigen ligand, and coligation of CD72 and BCR inhibits BCR signaling. Mechanistically, ligand binding leads to the recruitment of PTPN6/SHP-1 to the BCR complex which is inhibitory to BCR signaling. Acts also as a ligand for CD5 and thereby plays a critical role in maintaining regulatory T and B-cell homeostasis.
See full target information CD72
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cardiovascular research 118:1303-1320 PubMed34100920

2021

Single-cell transcriptomic analyses of cardiac immune cells reveal that Rel-driven CD72-positive macrophages induce cardiomyocyte injury.

Applications

Unspecified application

Species

Unspecified reactive species

Shi-Hao Ni,Jin-Dong Xu,Shu-Ning Sun,Yue Li,Zheng Zhou,Huan Li,Xin Liu,Jian-Ping Deng,Yu-Sheng Huang,Zi-Xin Chen,Wen-Jun Feng,Jia-Jia Wang,Shao-Xiang Xian,Zhong-Qi Yang,Sheng Wang,Ling-Jun Wang,Lu Lu
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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