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AB199001

Anti-CD79a antibody [JCB117 + HM47A9]

5

(2 Reviews)

|

(5 Publications)

Mouse Multiclonal CD79A antibody. Suitable for IHC-P and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human CD79A.

View Alternative Names

CD79a, IGA, MB1, CD79A, B-cell antigen receptor complex-associated protein alpha chain, Ig-alpha, MB-1 membrane glycoprotein, Membrane-bound immunoglobulin-associated protein, Surface IgM-associated protein

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD79a antibody [JCB117 + HM47A9] (AB199001)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD79a antibody [JCB117 + HM47A9] (AB199001)

Immunohistochemical analysis of Formalin-fixed, paraffin-embedded Human tonsil tissue labeling CD79a with ab199001 at 1μg/mL.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD79a antibody [JCB117 + HM47A9] (AB199001)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD79a antibody [JCB117 + HM47A9] (AB199001)

Immunohistochemical analysis of Formalin-fixed, paraffin-embedded Human tonsil tissue labeling CD79a with ab199001 at 1μg/mL.

Key facts

Host species

Mouse

Clonality

Multiclonal

Clone number

JCB117 + HM47A9

Isotype

IgG1

Light chain type

kappa

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human CD79A. The exact immunogen used to generate this antibody is proprietary information.

P11912

Specificity

ab199001 is generally used to complement anti-CD20 especially for mature B-cell lymphomas after treatment with anti-CD20. ab199001 will stain many of the same lymphomas as anti-CD20, but also is more likely to stain B-lymphoblastic lymphoma/leukemia than is anti-CD20. Anti-CD79a also stains more cases of plasma cell myeloma and occasionally some types of endothelial cells as well.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "0.5-1 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Product details

Both antibodies (JCB117 + HM47/A9) are mouse IgG1 kappa.

What is an oligoclonal antibody?
This oligoclonal antibody is a cocktail of monoclonal antibodies that have been carefully selected. Oligoclonal antibodies have not only the specificity and batch-to-batch consistency of a monoclonal antibody, but also have the advantage of the sensitivity of a polyclonal antibody due to their ability to recognize multiple epitopes on an antigen.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD79a also known as Ig-alpha or MB-1 is a component of the B cell antigen receptor (BCR) complex. It is a transmembrane protein with a molecular mass of approximately 47 kDa. CD79a is part of a heterodimer with CD79b and is mainly expressed on the surface of B lymphocytes. This protein plays a critical mechanical role in signaling transduction through the BCR by associating with membrane-bound immunoglobulin molecules helping to initiate the immune response upon antigen binding.
Biological function summary

This protein acts as an essential mediator in the immune system. CD79a together with CD79b forms part of the BCR complex critical for B cell development and maturation. The BCR complex activates signaling cascades that influence B cell fate decisions such as proliferation differentiation and apoptosis. By transmitting signals from the BCR CD79a helps regulate these cellular functions necessary for efficient immune defense.

Pathways

CD79a plays a pivotal role in the B cell receptor signaling pathway. This pathway involves signaling molecules such as spleen tyrosine kinase (SYK) and phosphoinositide 3-kinase (PI3K) which are activated upon BCR engagement. CD79a acts in concert with other proteins including CD79b and the IgM receptor facilitating downstream signaling cascades that ensure proper B cell responses. Its role is important for linking extracellular antigen recognition to intracellular signaling events.

CD79a is significant in conditions like B cell lymphomas and certain immunodeficiencies. Abnormal expression or mutations in CD79a are associated with some types of non-Hodgkin lymphoma. The protein's interaction with CD79b is particularly relevant as alterations in these proteins' function or expression can impact B cell development and lead to pathogenesis in lymphoproliferative disorders. Consequently CD79a serves as an important biomarker and potential therapeutic target in these diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.
See full target information CD79A
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Journal of gastrointestinal oncology 13:1959-1966 PubMed36092319

2022

The role of tumor-infiltrating B cells in the tumor microenvironment of hepatocellular carcinoma and its prognostic value: a bioinformatics analysis.

Applications

Unspecified application

Species

Unspecified reactive species

Jixue Zou,Chubin Luo,Haoyang Xin,Tongchun Xue,Xiaoying Xie,Rongxin Chen,Lan Zhang

Folia histochemica et cytobiologica 60:136-145 PubMed35661993

2022

Immunohistochemical analysis of the thymus in newborn and adult yaks (Bos grunniens).

Applications

Unspecified application

Species

Unspecified reactive species

Qian Zhang,Yan Cui,Sijiu Yu,Junfeng He,Meng Wang,Yangyang Pan,Kun Yang,Kun Yang

Folia morphologica 81:91-100 PubMed34642930

2021

Immune cells in the small intestinal mucosa of newborn yaks.

Applications

Unspecified application

Species

Unspecified reactive species

Q Zhang,Y Cui,S J Yu,Y F Huang,Y Y Pan,Z C Bai

Genome biology 21:152 PubMed32580738

2020

Single-cell transcriptome and antigen-immunoglobin analysis reveals the diversity of B cells in non-small cell lung cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Jian Chen,Yun Tan,Fenghuan Sun,Likun Hou,Chi Zhang,Tao Ge,Huansha Yu,Chunxiao Wu,Yuming Zhu,Liang Duan,Liang Wu,Nan Song,Liping Zhang,Wei Zhang,Di Wang,Chang Chen,Chunyan Wu,Gening Jiang,Peng Zhang

Nature immunology 18:1150-1159 PubMed28805811

2017

Caveolin-1-dependent nanoscale organization of the BCR regulates B cell tolerance.

Applications

Unspecified application

Species

Unspecified reactive species

Susana Minguet,Kathrin Kläsener,Anna-Maria Schaffer,Gina J Fiala,Teresa Osteso-Ibánez,Katrin Raute,Inmaculada Navarro-Lérida,Frederike A Hartl,Maximilian Seidl,Michael Reth,Miguel A Del Pozo
View all publications
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