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AB215166

Anti-CD80 antibody

4

(4 Reviews)

|

(11 Publications)

Rabbit Polyclonal Cd80 molecule antibody. Suitable for WB and reacts with Mouse samples. Cited in 11 publications.

View Alternative Names

Cd80

1 Images
Western blot - Anti-CD80 antibody (AB215166)
  • WB

Lab

Western blot - Anti-CD80 antibody (AB215166)

All lanes:

Western blot - Anti-CD80 antibody (ab215166) at 1/500 dilution

All lanes:

Mouse spleen lysates

Secondary

All lanes:

Conjugated secondary antibody at 1/10000 dilution

Predicted band size: 33 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD80 also known as B7-1 is a cell surface protein with a molecular weight of approximately 60 kDa. It is expressed on antigen-presenting cells such as dendritic cells macrophages and B cells. The CD80 protein plays a mechanical role in immune response modulation by providing necessary signals for T cell activation and survival. CD80 interacts with receptors CD28 and CTLA-4 on T cells serving as a costimulatory molecule important for productive immune responses.
Biological function summary

CD80 plays a significant role in the immune system's ability to distinguish between self and non-self. It belongs to the B7 family and participates in the formation of immunological synapses between T cells and antigen-presenting cells. This interaction is essential for triggering T cell proliferation and cytokine production forming a part of the adaptive immune response. CD80's expression increases in response to pathogen recognition enhancing the immune system's efficiency.

Pathways

CD80 is integral to the regulation of T cell-mediated immune responses. It is involved in the CD28 co-stimulatory pathway which is vital for T cell activation and function. In this pathway CD80 interacts with proteins like CD28 and CTLA-4 to modulate immune activation and regulate immune tolerance. The proper function of CD80 within this pathway ensures a balanced immune reaction preventing autoimmunity while allowing effective defense against pathogens.

CD80 plays a role in autoimmune conditions and transplantation rejection. Its overexpression or dysregulation can contribute to diseases such as rheumatoid arthritis where it modifies T cell response and inflammation. Additionally CD80 is implicated in organ transplantation influencing graft rejection outcomes due to its role in modulating immune activation. Understanding CD80 interactions with CTLA-4 and CD28 offers insight into these conditions providing potential targets for therapeutic intervention.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Cd80 molecule
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Publications (11)

Recent publications for all applications. Explore the full list and refine your search

Inflammation 48:1728-1744 PubMed39424751

2024

Exosomes Derived from Bone Marrow Dendritic Cells Exhibit Protective and Therapeutic Potential Against Chemically Induced Chronic Pancreatitis in Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Shaimaa M Bashir,Sherine M Rizk,Mohammed M Nooh,Hebatullah S Helmy

Translational oncology 47:102052 PubMed38981246

2024

Metformin induces tumor immunogenic cell death in ovarian cancer by activating AMPK pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yixiong Chen,Lufang Wang,Na Chen,Guiju Tang

Journal of Nippon Medical School = Nippon Ika Daigaku zasshi 91:285-295 PubMed38972741

2024

Candesartan Attenuates Vasculitis in a Mouse Model of Kawasaki Disease Induced by Candida albicans Water-Soluble Fraction.

Applications

Unspecified application

Species

Unspecified reactive species

Ryosuke Matsui,Ryuji Fukazawa,Ryohei Fukunaga,Yusuke Motoji,Yoshiaki Hashimoto,Makoto Watanabe,Noriko Nagi-Miura,Yasuhiko Itoh

Evidence-based complementary and alternative medicine : eCAM 2023:7000477 PubMed36874618

2023

Alleviates the Migration, Phagocytosis, and Inflammatory Response of Macrophages.

Applications

Unspecified application

Species

Unspecified reactive species

Shanmin Huang,Xuehua Zheng,Weiguo Dong,Yao Lin,Shu Jiang,Haiyin Zheng,Changhui Qian

The Journal of clinical investigation 133: PubMed36647821

2023

Karyopherin α deficiency contributes to human preimplantation embryo arrest.

Applications

Unspecified application

Species

Unspecified reactive species

Wenjing Wang,Yoichi Miyamoto,Biaobang Chen,Juanzi Shi,Feiyang Diao,Wei Zheng,Qun Li,Lan Yu,Lin Li,Yao Xu,Ling Wu,Xiaoyan Mao,Jing Fu,Bin Li,Zheng Yan,Rong Shi,Xia Xue,Jian Mu,Zhihua Zhang,Tianyu Wu,Lin Zhao,Weijie Wang,Zhou Zhou,Jie Dong,Qiaoli Li,Li Jin,Lin He,Xiaoxi Sun,Ge Lin,Yanping Kuang,Lei Wang,Qing Sang

International journal of immunopathology and pharmacology 36:3946320221137464 PubMed36347039

2022

PM2.5 activated NLRP3 inflammasome and IL-1β release in MH-S cells by facilitating autophagy via activating Wnt5a.

Applications

Unspecified application

Species

Unspecified reactive species

Guanli Yuan,Yinfeng Liu,Zheng Wang,Xiaotong Wang,Zhuoxiao Han,Xixin Yan,Aihong Meng

Biomedicines 10: PubMed35892695

2022

Kawasaki Disease-like Vasculitis Facilitates Atherosclerosis, and Statin Shows a Significant Antiatherosclerosis and Anti-Inflammatory Effect in a Kawasaki Disease Model Mouse.

Applications

Unspecified application

Species

Unspecified reactive species

Yusuke Motoji,Ryuji Fukazawa,Ryosuke Matsui,Noriko Nagi-Miura,Yasuo Miyagi,Yasuhiko Itoh,Yosuke Ishii

Theranostics 12:4606-4628 PubMed35832091

2022

Single-cell transcriptome profiling of the immune space-time landscape reveals dendritic cell regulatory program in polymicrobial sepsis.

Applications

Unspecified application

Species

Unspecified reactive species

Ren-Qi Yao,Zhi-Xuan Li,Li-Xue Wang,Yu-Xuan Li,Li-Yu Zheng,Ning Dong,Yao Wu,Zhao-Fan Xia,Timothy R Billiar,Chao Ren,Yong-Ming Yao

Frontiers in cellular and infection microbiology 11:783049 PubMed35111693

2022

Intestinal Epithelial Cell Exosome Launches IL-1β-Mediated Neuron Injury in Sepsis-Associated Encephalopathy.

Applications

Unspecified application

Species

Unspecified reactive species

Shaosong Xi,Yunguang Wang,Chenghao Wu,Weihua Peng,Ying Zhu,Wei Hu

Cell death & disease 12:314 PubMed33762577

2021

Oleandrin, a cardiac glycoside, induces immunogenic cell death via the PERK/elF2α/ATF4/CHOP pathway in breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoxi Li,Jian Zheng,Shi Chen,Fan-Dong Meng,Jing Ning,Shu-Lan Sun
View all publications
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Product promise

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