AB233782

Anti-CD83 antibody [8A4C11]

Name: Anti-CD83 antibody [8A4C11] (ab233782) | Abcam
Brand: Abcam Limited
SKU: AB233782
Price: 525 USD
Availability: InStock

Be the first to review this product! Submit a review

(1 Publication)

Mouse Monoclonal CD83 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CD83 aa 1-150.

View Alternative Names

CD83, CD83 antigen, hCD83, B-cell activation protein, Cell surface protein HB15

2 Images

Lab

Western blot - Anti-CD83 antibody [8A4C11] (AB233782)

Expected MW is 40.1 kDa.

All lanes:

Western blot - Anti-CD83 antibody [8A4C11] (ab233782) at 1/500 dilution

All lanes:

Recombinant human CD83 (aa 20-144) protein

Predicted band size: 23 kDa

false

Supplier Data

Western blot - Anti-CD83 antibody [8A4C11] (AB233782)

All lanes:

Western blot - Anti-CD83 antibody [8A4C11] (ab233782) at 1/500 dilution

Lane 1:

Untransfected HEK-293 (human epithelial cell line from embryonic kidney) cell lysate

Lane 2:

Human CD83 (aa 20-144)-hIgG-Fc-transfected HEK-293 cell lysate

Predicted band size: 23 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

8A4C11

Isotype

IgG1

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Recombinant Fragment Protein within Human CD83 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

Q01151

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" } } }

style

left-column

style

left-column

Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Purification notes

Purified from tissue culture supernatant.

Storage buffer

Preservative: 0.05% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

style

left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD83 also known as 3D11 in some contexts is a protein with important roles in the immune system. The CD83 protein is a glycoprotein with a molecular mass of approximately 45 kDa. It is expressed in various immune cells including dendritic cells B cells thymic epithelial cells and activated T cells. CD83 acts as a surface marker during the maturation and activation of these cells. This characteristic makes it a useful marker in immunological studies often referred to by scientists as the CD83 marker.

Biological function summary

The primary role of CD83 involves the regulation of immune responses. It functions by modulating the activity and communication of immune cells especially impacting the antigen-presenting capabilities of dendritic cells. CD83 also plays a role in promoting the maturation of these cells and influencing T-cell responses. Although CD83 is not generally recognized as a part of a complex its interactions with other cell surface molecules are significant for immune system function.

Pathways

CD83 has notable involvement in immune signaling pathways including the NF-kB and JAK/STAT pathways. These pathways are critical for transmitting signals that influence cell survival proliferation and activation. Through these pathways CD83 interacts with proteins such as cytokines and growth factors which further modulate their effects on immune cells and their responses.

Understanding CD83’s role provides insights into conditions like autoimmune diseases and immune deficiencies. In autoimmune diseases irregular expression or function of CD83 can disrupt normal immune response contributing to pathogenesis. Its relationship with other proteins such as CD28 in T-cell activation underlies its involvement in disorders characterized by immune dysregulation. Furthermore CD83 expression profiles may help decipher cancer immune evasion mechanisms providing possible therapeutic targets.

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.

See full target information CD83

style

left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Biomolecules & biomedicine 24:848-856 PubMed38149831

2023

Hypomethylation of the promoter region contributes to the occurrence and development of ovarian endometriosis via the AKT/mTOR/4EBP1 signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yuzhen Qin,Yishuai Li,Yali Hao,Yan Li,Shan Kang

View all publications

style

left-column

style

left-column

style

right-column

Alternative Products

Primary Antibodies

AB234233

PE/Cy5® Anti-CD83 antibody [HB15e]

Flow Cytometry - PE/Cy5® Anti-CD83 antibody [HB15e] (AB234233)

Primary Antibodies

AB48318

FITC Anti-CD83 antibody [Michel-19]

Flow Cytometry - FITC Anti-CD83 antibody [Michel-19] (AB48318)

Primary Antibodies

AB244204

Anti-CD83 antibody [EPR22405]

RabMAb|Recombinant

Flow Cytometry - Anti-CD83 antibody [EPR22405] (AB244204)

Primary Antibodies

AB245986

Anti-CD83 antibody [EPR22405] - BSA and Azide free

RabMAb|Recombinant

Flow Cytometry - Anti-CD83 antibody [EPR22405] - BSA and Azide free (AB245986)

Primary Antibodies

AB205343

Anti-CD83 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD83 antibody (AB205343)

Complementary Products

Assay Kits

AB277711

Human CD83 ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Human CD83 ELISA Kit (AB277711)

Primary Antibodies

AB224639

Anti-CD40 antibody [EPR20735]

RabMAb|Recombinant|KO Validated|20ul selling size

Flow Cytometry - Anti-CD40 antibody [EPR20735] (AB224639)

Primary Antibodies

AB52632

Anti-CD11c antibody [EP1347Y] - C-terminal

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD11c antibody [EP1347Y] - C-terminal (AB52632)

Primary Antibodies

AB239075

Anti-CD86 antibody [EPR21962]

20ul selling size|RabMAb|Recombinant|KO Validated

Flow Cytometry - Anti-CD86 antibody [EPR21962] (AB239075)

Primary Antibodies

AB205921

Anti-PD-L1 antibody [28-8]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PD-L1 antibody [28-8] (AB205921)

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com