AB205343

Anti-CD83 antibody

Be the first to review this product! Submit a review

|

(6 Publications)

Rabbit Polyclonal CD83 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CD83 aa 50-150.

View Alternative Names

CD83, CD83 antigen, hCD83, B-cell activation protein, Cell surface protein HB15

5 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD83 antibody (AB205343)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD83 antibody (AB205343)

Immunohistochemical analysis of formalin/PFA-fixed paraffin-embedded human tonsil tissue sections labeling CD83 with ab205343 at a 1/50 dilution.

Immunocytochemistry/ Immunofluorescence - Anti-CD83 antibody (AB205343)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-CD83 antibody (AB205343)

Immunofluorescence analysis of formalin fixed, Triton X-100 permealized A431 cells, labeling CD83 with ab205343 at 4 μg/mL.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD83 antibody (AB205343)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD83 antibody (AB205343)

Immunohistochemical analysis of human colon tissue labeling CD83 with ab205343 at 1/200 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD83 antibody (AB205343)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD83 antibody (AB205343)

Immunohistochemical analysis of human enometrium tissue labeling CD83 with ab205343 at 1/200 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD83 antibody (AB205343)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD83 antibody (AB205343)

Immunohistochemical analysis of human tonsil tissue labeling CD83 with ab205343 at 1/200 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

Immunogen

Recombinant Fragment Protein within Human CD83 aa 50-150. The exact immunogen used to generate this antibody is proprietary information.

style

left-column

Alternative Products

Primary Antibodies

AB244204

Anti-CD83 antibody [EPR22405]

RabMAb|Recombinant

Flow Cytometry - Anti-CD83 antibody [EPR22405] (AB244204)

0
0

Primary Antibodies

AB234233

PE/Cy5® Anti-CD83 antibody [HB15e]

Flow Cytometry - PE/Cy5® Anti-CD83 antibody [HB15e] (AB234233)

0
0

Primary Antibodies

AB234119

APC Anti-CD83 antibody [HB15e]

Flow Cytometry - APC Anti-CD83 antibody [HB15e] (AB234119)

0
0

Primary Antibodies

AB234242

PE Anti-CD83 antibody [HB15e]

Flow Cytometry - PE Anti-CD83 antibody [HB15e] (AB234242)

0
0

Primary Antibodies

AB48318

FITC Anti-CD83 antibody [Michel-19]

Flow Cytometry - FITC Anti-CD83 antibody [Michel-19] (AB48318)

0
0

Primary Antibodies

AB245986

Anti-CD83 antibody [EPR22405] - BSA and Azide free

RabMAb|Recombinant

Flow Cytometry - Anti-CD83 antibody [EPR22405] - BSA and Azide free (AB245986)

0
0

Primary Antibodies

AB233782

Anti-CD83 antibody [8A4C11]

Western blot - Anti-CD83 antibody [8A4C11] (AB233782)

0
0

Complementary Products

Primary Antibodies

AB224639

Anti-CD40 antibody [EPR20735]

RabMAb|Recombinant|KO Validated|20ul selling size

Flow Cytometry - Anti-CD40 antibody [EPR20735] (AB224639)

0
0

Primary Antibodies

AB52632

Anti-CD11c antibody [EP1347Y] - C-terminal

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD11c antibody [EP1347Y] - C-terminal (AB52632)

5
18

Primary Antibodies

AB239075

Anti-CD86 antibody [EPR21962]

20ul selling size|RabMAb|Recombinant|KO Validated

Flow Cytometry - Anti-CD86 antibody [EPR21962] (AB239075)

0
0

Primary Antibodies

AB205921

Anti-PD-L1 antibody [28-8]

BOND RX™ Validated|20ul selling size|Recombinant|KO Validated|Advanced Validation|RabMAb

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PD-L1 antibody [28-8] (AB205921)

4
15

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }

style

left-column

style

left-column

Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

style

left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD83 also known as 3D11 in some contexts is a protein with important roles in the immune system. The CD83 protein is a glycoprotein with a molecular mass of approximately 45 kDa. It is expressed in various immune cells including dendritic cells B cells thymic epithelial cells and activated T cells. CD83 acts as a surface marker during the maturation and activation of these cells. This characteristic makes it a useful marker in immunological studies often referred to by scientists as the CD83 marker.

Biological function summary

The primary role of CD83 involves the regulation of immune responses. It functions by modulating the activity and communication of immune cells especially impacting the antigen-presenting capabilities of dendritic cells. CD83 also plays a role in promoting the maturation of these cells and influencing T-cell responses. Although CD83 is not generally recognized as a part of a complex its interactions with other cell surface molecules are significant for immune system function.

Pathways

CD83 has notable involvement in immune signaling pathways including the NF-kB and JAK/STAT pathways. These pathways are critical for transmitting signals that influence cell survival proliferation and activation. Through these pathways CD83 interacts with proteins such as cytokines and growth factors which further modulate their effects on immune cells and their responses.

Understanding CD83’s role provides insights into conditions like autoimmune diseases and immune deficiencies. In autoimmune diseases irregular expression or function of CD83 can disrupt normal immune response contributing to pathogenesis. Its relationship with other proteins such as CD28 in T-cell activation underlies its involvement in disorders characterized by immune dysregulation. Furthermore CD83 expression profiles may help decipher cancer immune evasion mechanisms providing possible therapeutic targets.

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

Transmembrane glycoprotein predominantly found on the surface of many immune cells including dendritic cells or lymphocytes that plays various roles in immune response regulation. Plays an essential role in CD4(+) T-selection, differentiation and stability by regulating the activity of the major E3 ubiquitin ligase responsible for controlling MHCII trafficking MARCHF8. Also inhibits MARCHF1 association with MHCII or CD86 to prevent their ubiquitination and subsequent degradation (PubMed : 21220452). In addition, acts as an important modulator of protective responses against acute infections (By similarity).

See full target information CD83

style

left-column

Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Journal of clinical medicine 13: PubMed38610835

2024

The Impact of Phenotype of Inflammatory Bowel Diseases, Inflammation Activity and Therapy on Mucosal Mature Cd83 Dendritic Cell.

Applications

Unspecified application

Species

Unspecified reactive species

Bruna Rošić Despalatović,Marija Babić,Andre Bratanić,Ante Tonkić,Žarko Ardalić,Katarina Vilović

Aging 13:14131-14158 PubMed34001679

2021

Downregulation of USP18 reduces tumor-infiltrating activated dendritic cells in extranodal diffuse large B cell lymphoma patients.

Applications

Unspecified application

Species

Unspecified reactive species

Chong Zhao,Runzhi Huang,Zhiwei Zeng,Shaoxin Yang,Wei Lu,Jiali Liu,Yanyu Wei,Hezhou Guo,Yanjie Zhang,Penghui Yan,Zongqiang Huang,Jun Shi

Methods in molecular biology (Clifton, N.J.) 2265:573-587 PubMed33704741

2021

Multiplex Immunofluorescence Histology for Immune Cell Infiltrates in Melanoma-Associated Tertiary Lymphoid Structures.

Applications

Unspecified application

Species

Unspecified reactive species

Ileana S Mauldin,Adela Mahmutovic,Samuel J Young,Craig L Slingluff

Cancers 12: PubMed32823589

2020

CD83, a Novel MAPK Signaling Pathway Interactor, Determines Ovarian Cancer Cell Fate.

Applications

Unspecified application

Species

Unspecified reactive species

Aalia Batool,Hao Liu,Yi-Xun Liu,Su-Ren Chen

Scientific reports 10:10055 PubMed32572123

2020

Difference in Presence and Number of CD83 Dendritic Cells in Patients with Ulcerative Colitis and Crohn's Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Bruna Rošić Despalatović,Marija Babić,Andre Bratanić,Ante Tonkić,Katarina Vilović

Clinical and experimental immunology 188:420-429 PubMed28052400

2017

Programmed death-1 ligands 1 and 2 expression in cutaneous squamous cell carcinoma and their relationship with tumour- infiltrating dendritic cells.

Applications

Unspecified application

Species

Unspecified reactive species

Q Jiao,C Liu,W Li,W Li,F Fang,Q Qian,X Zhang

View all publications

style

left-column

style

left-column

style

right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com