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AB53357

Anti-CD89 antibody [MIP7c]

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(1 Publication)

Mouse Monoclonal CD89 antibody. Suitable for FuncS (Neut/Block) and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Native Full Length Protein corresponding to Human FCAR.

View Alternative Names

CD89, FCAR, Immunoglobulin alpha Fc receptor, IgA Fc receptor

1 Images
Functional Studies (Neut/Block) - Anti-CD89 antibody [MIP7c] (AB53357)
  • FuncS (Neut/Block)

Unknown

Functional Studies (Neut/Block) - Anti-CD89 antibody [MIP7c] (AB53357)

Neutrophil phagocytosis of IgA immune complexes in presence or absence (control) of ab53357.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

MIP7c

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

FuncS (Neut/Block)

applications

Immunogen

Native Full Length Protein corresponding to Human FCAR.

P24071

Specificity

ab53357 recognises the EC1 domain of the CD89 extracellular region.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FuncSNeutBlock" : {"fullname" : "Functional Studies (Neut/Block)", "shortname":"FuncS (Neut/Block)"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FuncSNeutBlock-species-checked": "testedAndGuaranteed", "FuncSNeutBlock-species-dilution-info": "4 µg for 10^5 Cells", "FuncSNeutBlock-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
Up to 12 months
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD89 also known as the Fc alpha receptor (FcαR) is a protein receptor with a molecular mass of approximately 55 to 75 kDa. It is encoded by the FCAR gene and predominantly expressed on myeloid cells such as neutrophils eosinophils monocytes and some macrophages. CD89 acts as an important component of the immune system by binding to the Fc region of immunoglobulin A (IgA) facilitating various immune responses. This receptor mediates diverse immune functions by activating cellular responses upon IgA ligand binding.
Biological function summary

CD89 plays an important role in regulating immune surveillance and response. It associates with the gamma chain of the Fc receptor complex which is necessary for its signaling ability. The binding of IgA to CD89 triggers various processes including phagocytosis antibody-dependent cellular cytotoxicity (ADCC) and the release of pro-inflammatory cytokines. These processes are fundamental for host defense against pathogens particularly those entering through mucosal surfaces where IgA is typically abundant.

Pathways

CD89 is part of the immune effector pathway and participates actively in the immunoregulatory signaling cascade. One significant pathway is the IgA-mediated immune response pathway where CD89 cooperates with other Fc receptors and integrins to clear infections. Additionally its interaction with the complement system enhances opsonization and pathogen elimination. Related proteins in these pathways include other Fc receptors like FcγR which share similar signaling mechanisms and immune functions.

CD89 is associated with conditions involving dysregulated immune responses or infections. For example it is implicated in IgA nephropathy where abnormal IgA deposits in the kidneys may trigger inflammation through CD89-mediated pathways. Furthermore alterations in CD89 expression or function have been studied in the context of inflammatory bowel disease (IBD) illustrating the receptor's role in aberrant immune responses. The target’s interaction with proteins such as IgA and complement C3 provides insight into its involvement in these pathological conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.
See full target information FCAR
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in immunology 9:244 PubMed29651286

2018

IgA Targeting Human Immunodeficiency Virus-1 Envelope gp41 Triggers Antibody-Dependent Cellular Cytotoxicity Cross-Clade and Cooperates with gp41-Specific IgG to Increase Cell Lysis.

Applications

Unspecified application

Species

Unspecified reactive species

Maxence Duchemin,Marwa Khamassi,Lin Xu,Daniela Tudor,Morgane Bomsel
View all publications
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Product promise

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