Anti-Cdc26 / Apc12 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Cdc26 also known as Apc12 is a protein that plays a mechanical role as a subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C). This protein complex is essential for cell cycle regulation especially during the transition from metaphase to anaphase. Cdc26 has a mass of approximately 90 kDa. Expression of Cdc26 occurs mainly in dividing cells indicating its involvement in processes requiring tight cell cycle control.

Biological function summary

Cdc26/Apc12 functions as a component of the APC/C which is important for ubiquitin-mediated proteolysis of cell cycle proteins. As part of this large multi-subunit complex it aids the degradation of securin and cyclins which are proteins needed for cell cycle progression. The activity of Cdc26 is necessary to ensure correct chromosome separation during mitosis making it fundamental for maintaining genomic stability.

Pathways

Cdc26 integrates into cell cycle regulatory pathways particularly in the mitotic exit and G1 maintenance. It collaborates closely with other proteins such as Cdc20 and Cdh1 which together regulate the activity of the APC/C complex. These interactions highlight its role within the ubiquitin-proteasome signaling pathway and highlight its importance in maintaining orderly progression through the cell cycle.

Associated diseases and disorders

Cdc26 is implicated in cancer due to its critical function in cell cycle regulation and maintenance of genomic integrity. Aberrant expression or malfunction of Cdc26 may lead to uncontrolled cell division contributing to tumorigenesis. Other proteins related to Cdc26 in cancer pathways like Cyclin B1 also play significant roles in uncontrolled cell proliferation. Additionally Cdc26 has associations with genetic disorders affecting cell division further underlining its significance in healthy cellular function.