Mouse Monoclonal CDK1 antibody. Suitable for WB and reacts with Schizosaccharomyces pombe samples. Cited in 26 publications. Immunogen corresponding to Synthetic Peptide within Schizosaccharomyces pombe 972h- cdc2.
Preservative: 0.02% Sodium azide
Constituents: 99.98% PBS
| WB | |
|---|---|
| Schizosaccharomyces pombe | Expected |
| Species | Dilution info | Notes |
|---|---|---|
Species Schizosaccharomyces pombe | Dilution info Use at an assay dependent concentration. | Notes - |
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Cyclin-dependent kinase that acts as a master regulator of the mitotic and meiotic cell cycles (PubMed:1896017, PubMed:2274045, PubMed:6581157, PubMed:7498766, PubMed:8087848, PubMed:9042863, Ref.6). Required to drive the G1-S and G2-M transitions, and initiation of premeiotic DNA replication and meiosis II (PubMed:1896017, PubMed:2274045, PubMed:6581157, PubMed:7498766, PubMed:8087848, PubMed:9042863, Ref.6). More than 200 substrates have been identified (PubMed:27984725). Substrate specificity is in part regulated by the bound cyclin protein (PubMed:27984725). When complexed with cyclin cig2, it drives the G1-S phase transition (PubMed:8087848). When complexed with cyclin cdc13, it drives the G2-M transition and initiation of meiosis II (PubMed:7498766, PubMed:8087848). Its activity rises throughout the cell cycle and substrate specificity is further influenced by activity thresholds with more sensitive substrates phosphorylated earlier in the cell cycle than less sensitive substrates (PubMed:27984725). Phosphorylates dis1 during metaphase to ensure proper microtubule dynamics and accurate chromosome segregation (PubMed:16920624). Phosphorylates the repetitive C-terminus of the large subunit of RNA polymerase II rpb1 (Probable). Inactivated by checkpoint signaling following detection of cellular damage, leading to cell cycle arrest to allow damage repair (PubMed:16049013, PubMed:9042863). Inactivated during G2 DNA damage checkpoint signaling (PubMed:9042863). Inactivated in response to defective RNA splicing (PubMed:16049013).
cdk1, swo2, tws1, pi002, SPBC11B10.09, cdc2, Cyclin-dependent kinase 1, CDK1, Cell division control protein 2, Cell division protein kinase 1, p34 protein kinase
Mouse Monoclonal CDK1 antibody. Suitable for WB and reacts with Schizosaccharomyces pombe samples. Cited in 26 publications. Immunogen corresponding to Synthetic Peptide within Schizosaccharomyces pombe 972h- cdc2.
Preservative: 0.02% Sodium azide
Constituents: 99.98% PBS
We have tested this species and application combination and it works. It is covered by our product promise.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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