AB86340

Anti-CDK5RAP2 antibody

Name: Anti-CDK5RAP2 antibody (ab86340) | Abcam
Brand: Abcam Limited
SKU: AB86340
Price: 535 USD
Availability: InStock
Rating: 5 (1 reviews)

(1 Review)

(7 Publications)

Rabbit Polyclonal CDK5RAP2 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human CDK5RAP2 aa 1800 to C-terminus.

View Alternative Names

CEP215, KIAA1633, CDK5RAP2, CDK5 regulatory subunit-associated protein 2, CDK5 activator-binding protein C48, Centrosome-associated protein 215

2 Images

Immunocytochemistry/ Immunofluorescence - Anti-CDK5RAP2 antibody (AB86340)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-CDK5RAP2 antibody (AB86340)

ab86340 at 1/250 dilution staining CDK5RAP2 in NBF-fixed asynchronous HeLa cells by Imunofluorescence.
Detection : Anti-rabbit IgG-FITC conjugated used at a dilution of 1/100.

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-CDK5RAP2 antibody (AB86340)

ab86340 at 1/250 dilution staining CDK5RAP2 in NBF-fixed asynchronous HeLa cells by Imunofluorescence.
Detection : Anti-rabbit IgG-FITC conjugated used at a dilution of 1/100.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Synthetic Peptide within Human CDK5RAP2 aa 1800 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q96SN8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/500", "ICCIF-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 6.8 - 7.4 Preservative: 0.09% Sodium azide Constituents: Tris buffered saline, 0.1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gamma-TuRC) onto centrosomes (PubMed : 26485573). In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery (PubMed : 29162697). Required for the recruitment of AKAP9 to centrosomes (PubMed : 29162697). Plays a role in neurogenesis (By similarity).

See full target information CDK5RAP2

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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in immunology 13:749336 PubMed35222363

2022

Idebenone Regulates Aβ and LPS-Induced Neurogliosis and Cognitive Function Through Inhibition of NLRP3 Inflammasome/IL-1β Axis Activation.

Applications

Unspecified application

Species

Unspecified reactive species

Hyun-Ju Lee,Jin-Hee Park,Hyang-Sook Hoe

Frontiers in immunology 12:684344 PubMed34122447

2021

Sorafenib Modulates the LPS- and Aβ-Induced Neuroinflammatory Response in Cells, Wild-Type Mice, and 5xFAD Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Jieun Kim,Jin-Hee Park,Seon Kyeong Park,Hyang-Sook Hoe

The Journal of cell biology 220: PubMed33983387

2021

TRIM37 prevents formation of condensate-organized ectopic spindle poles to ensure mitotic fidelity.

Applications

Unspecified application

Species

Unspecified reactive species

Franz Meitinger,Dong Kong,Midori Ohta,Arshad Desai,Karen Oegema,Jadranka Loncarek

The Journal of cell biology 219: PubMed33170211

2020

Centriole-independent mitotic spindle assembly relies on the PCNT-CDK5RAP2 pericentriolar matrix.

Applications

Unspecified application

Species

Unspecified reactive species

Sadanori Watanabe,Franz Meitinger,Andrew K Shiau,Karen Oegema,Arshad Desai

Nature 585:440-446 PubMed32908304

2020

TRIM37 controls cancer-specific vulnerability to PLK4 inhibition.

Applications

Unspecified application

Species

Unspecified reactive species

Franz Meitinger,Midori Ohta,Kian-Yong Lee,Sadanori Watanabe,Robert L Davis,John V Anzola,Ruth Kabeche,David A Jenkins,Andrew K Shiau,Arshad Desai,Karen Oegema

Oncotarget 6:34358-74 PubMed26452038

2015

The androgen receptor controls expression of the cancer-associated sTn antigen and cell adhesion through induction of ST6GalNAc1 in prostate cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Jennifer Munkley,Sebastian Oltean,Daniel Vodák,Brian T Wilson,Karen E Livermore,Yan Zhou,Eleanor Star,Vasileios I Floros,Bjarne Johannessen,Bridget Knight,Paul McCullagh,John McGrath,Malcolm Crundwell,Rolf I Skotheim,Craig N Robson,Hing Y Leung,Lorna W Harries,Prabhakar Rajan,Ian G Mills,David J Elliott

Nature genetics 44:277-84 PubMed22306653

2012

Germline mutations in DIS3L2 cause the Perlman syndrome of overgrowth and Wilms tumor susceptibility.

Applications

Unspecified application

Species

Unspecified reactive species

Dewi Astuti,Mark R Morris,Wendy N Cooper,Raymond H J Staals,Naomi C Wake,Graham A Fews,Harmeet Gill,Dean Gentle,Salwati Shuib,Christopher J Ricketts,Trevor Cole,Anthonie J van Essen,Richard A van Lingen,Giovanni Neri,John M Opitz,Patrick Rump,Irene Stolte-Dijkstra,Ferenc Müller,Ger J M Pruijn,Farida Latif,Eamonn R Maher

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CDK5RAP2 antibody

Immunocytochemistry/ Immunofluorescence - Anti-CDK5RAP2 antibody (AB86340)

Immunocytochemistry/ Immunofluorescence - Anti-CDK5RAP2 antibody (AB86340)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Publications (7)

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