AB196593

Anti-CDON / Cdo antibody

Name: Anti-CDON / Cdo antibody (ab196593) | Abcam
Brand: Abcam Limited
SKU: AB196593
Price: 520 USD
Availability: InStock

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(1 Publication)

Rabbit Polyclonal CDON / Cdo antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human CDON.

View Alternative Names

CDO, CDON, Cell adhesion molecule-related/down-regulated by oncogenes

1 Images

Immunocytochemistry/ Immunofluorescence - Anti-CDON / Cdo antibody (AB196593)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-CDON / Cdo antibody (AB196593)

Immunofluorescence analysis of MCF-7 cells labeling CDON / Cdo using ab196593 at a 1/100 dilution. Right image treated with synthesized peptide.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Synthetic Peptide within Human CDON. The exact immunogen used to generate this antibody is proprietary information.

Q4KMG0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/500", "ICCIF-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CDON also known as Cdo is a cell surface receptor that is part of the immunoglobulin superfamily. It typically has a mass of approximately 135 kDa. This receptor expresses mainly in developing and adult tissues that involve muscle and neuronal differentiation such as skeletal muscle and nervous system tissues. CDON possesses the ability to interact with extracellular matrix components contributing to its role in cellular adhesion events.

Biological function summary

The CDON protein acts as a part of a larger multi-protein complex. It is involved in pathways that regulate myogenic differentiation cell adhesion and cell signaling. CDON supports skeletal muscle development by facilitating interactions between cells and extracellular signals that guide cells towards the muscle lineage. It interacts with other proteins like Boc and Gas1 which help in modulating downstream signaling pathways important for proper tissue development.

Pathways

CDON plays a significant role in the Hedgehog signaling and Wnt signaling pathways. These pathways are essential for various cellular processes including tissue patterning and cellular proliferation. In the context of these pathways CDON associates with proteins such as Smoothened and Patched which serve as major constituents of Hedgehog signal transduction enabling the precise regulation of cellular responses during development.

CDON is associated with congenital conditions like holoprosencephaly and certain cancers particularly rhabdomyosarcoma. CDON interacts with proteins involved in these disorders such as SHH (Sonic Hedgehog) which plays a central role in the coordination of tissue growth and architecture. Disruptions in CDON-mediated pathways can lead to developmental anomalies or influence the progress of malignant transformations in tissues underlining its importance in both normal development and pathogenesis.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity).

See full target information CDON

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of cellular and molecular medicine 27:2437-2447 PubMed37436074

2023

PSMC4 promotes prostate carcinoma progression by regulating the CBX3-EGFR-PI3K-AKT-mTOR pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Kaifeng Liu,Shengmin Zhang,Yongzhan Gong,Panyan Zhu,Weigan Shen,Qi Zhang

View all publications

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Product promise

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For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CDON / Cdo antibody

Immunocytochemistry/ Immunofluorescence - Anti-CDON / Cdo antibody (AB196593)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

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