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AB183845

Anti-CDR2 antibody

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(1 Publication)

Rabbit Polyclonal CDR2 antibody. Suitable for WB, IHC-P, ICC/IF, IP and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CDR2 aa 200-400.

View Alternative Names

PCD17, CDR2, Cerebellar degeneration-related protein 2, Major Yo paraneoplastic antigen, Paraneoplastic cerebellar degeneration-associated antigen

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-CDR2 antibody (AB183845)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-CDR2 antibody (AB183845)

Immunofluorescent analysis of HeLa cells labeling CDR2 with ab183845 at 1/500. Image at the right costained with Hoechst 33342.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CDR2 antibody (AB183845)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CDR2 antibody (AB183845)

Immunohistochemical analysis of paraffin embedded Human breast carcinoma tissue labeling CDR2 with ab183845 at 1/500.

Immunoprecipitation - Anti-CDR2 antibody (AB183845)
  • IP

Supplier Data

Immunoprecipitation - Anti-CDR2 antibody (AB183845)

Samples were separated by 10% SDS-PAGE. The immunoprecipitated CDR2 protein was detected by ab183845 diluted at 1/1000 dilution.

All lanes:

Immunoprecipitation - Anti-CDR2 antibody (ab183845) at 2.5 µg

Lane 1:

293T whole cell extracts at 30 µg

Lane 2:

Control with 2.5 µg of pre-immune rabbit IgG

Lane 3:

Immunoprecipitated 293T whole cell extracts using ab183845

Secondary

All lanes:

Anti Rabbit IgG (HRP)

Predicted band size: 52 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P, WB, IP

applications

Immunogen

Recombinant Fragment Protein within Human CDR2 aa 200-400. The exact immunogen used to generate this antibody is proprietary information.

Q01850

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "<p></p>", "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "1/100 - 1/500", "IP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CDR2 also known as Cerebellar Degeneration-Related Protein 2 weighs approximately 52 kDa. It is primarily located in neuronal tissues particularly in the cerebellum. The protein is part of a family of proteins that share similarities including CDR2L which is also found in neuronal tissues. CDR2 plays a mechanical role in regulating neuron function and growth. While it has less common names this protein is consistently referred to in studies involving paraneoplastic neurological disorders.
Biological function summary

CDR2 regulates neuronal signaling and motor control. It interacts with proteins involved in cell cycle control and may form part of a protein complex affecting protein synthesis. Recent research suggests that CDR2 operates in regulating neuronal activity and response to cellular stress. The protein’s expression patterns indicate its significance in maintaining proper cerebellar function and coordination.

Pathways

CDR2 aligns with signaling pathways linked to cerebellar function and neurodegeneration. It is implicated in the mTOR signaling pathway which is important for cell growth and survival alongside proteins like mTOR and RICTOR. The protein is also associated with the beta-catenin signaling pathway suggesting its involvement in processes like cytoskeletal organization and neural cell adhesion.

CDR2 is connected to paraneoplastic cerebellar degeneration and certain types of cancers such as ovarian and breast cancer. These diseases link to the immune response against tumors that mistakenly target neuronal tissue. The protein Yo antibodies are associated with this condition showing a strong connection to CDR2. Their presence in patients indicates an autoimmune aspect where the target’s involvement leads to cerebellar damage and subsequent motor dysfunction.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information CDR2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell & bioscience 15:124 PubMed40877964

2025

Enriched environment inhibits GLT-1 ubiquitination by downregulating SMURF1 to attenuate ischemic brain injury induced excitotoxicity.

Applications

Unspecified application

Species

Unspecified reactive species

Yi Zhang,Wen Liu,Tao Huang,Lingling Liu,Xiuping Chen
View all publications
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Product promise

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