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AB278496

Anti-CDS1 antibody

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Rabbit Polyclonal CDS1 antibody. Suitable for WB, IHC-P and reacts with Human, Mouse samples. Immunogen corresponding to Recombinant Fragment Protein within Human CDS1.

View Alternative Names

CDS, CDS1, Phosphatidate cytidylyltransferase 1, CDP-DAG synthase 1, CDP-DG synthase 1, CDP-diacylglycerol synthase 1, CDP-diglyceride pyrophosphorylase 1, CDP-diglyceride synthase 1, CTP:phosphatidate cytidylyltransferase 1, CDS 1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CDS1 antibody (AB278496)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CDS1 antibody (AB278496)

Paraffin-embedded mouse stomach tissue stained for CDS1 using ab278496 at 1/500 dilution in immunohistochemical analysis.

Antigen retrieval : EDTA based, pH 8.0, 15 min.

Western blot - Anti-CDS1 antibody (AB278496)
  • WB

Supplier Data

Western blot - Anti-CDS1 antibody (AB278496)

10% SDS-PAGE gel.

All lanes:

Western blot - Anti-CDS1 antibody (ab278496) at 1/1000 dilution

Lane 1:

HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate at 30 µg

Lane 2:

HeLa nuclear extract at 30 µg

Secondary

All lanes:

HRP-conjugated anti-rabbit IgG antibody

Predicted band size: 53 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human CDS1. The exact immunogen used to generate this antibody is proprietary information.

Q92903

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/20000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CDS1 also known as CDP-diacylglycerol synthase 1 plays an important mechanical role in lipid metabolism by converting phosphatidic acid into CDP-diacylglycerol. This enzyme has a molecular mass of approximately 52 kDa and is expressed in a wide range of tissues throughout the body with notable expression in the brain heart and lungs. CDP-diacylglycerol synthase 1 participates in phospholipid biosynthesis which is essential for maintaining cell membrane integrity and function.
Biological function summary

CDP-diacylglycerol synthase 1 contributes to the regulation of phospholipid synthesis influencing the production of important signaling molecules. It functions not by forming complex with other proteins but through its enzymatic activity that provides substrates for the synthesis of phosphatidylinositol and phosphatidylglycerol. These phospholipids are fundamental components of cell membranes and play roles in signaling pathways that control cellular activities.

Pathways

CDP-diacylglycerol synthase 1 is integral to the phosphatidylinositol signaling pathway and the glycerophospholipid metabolism pathway. These pathways are critical for many cellular processes including signal transduction and membrane trafficking. Within these pathways CDS1 works in conjunction with enzymes like phospholipase C which hydrolyzes phosphatidylinositol affecting intracellular second messengers. Its activity connects with other lipid metabolizing proteins to ensure proper cell function and survival.

Researchers have linked defects in CDP-diacylglycerol synthase 1 to certain developmental and metabolic diseases notably Lowe syndrome and skeletal disorders. Its dysfunction may disrupt normal phospholipid metabolism impacting cellular signaling and structural integrity. This enzyme's alteration can affect related proteins such as enzymes responsible for phosphatidylinositol levels contributing to disease pathogenesis and necessitating targeted interventions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol (PubMed : 25375833, PubMed : 9407135). Exhibits almost no acyl chain preference for PA, showing no discrimination for the sn-1/sn-2 acyl chain composition of PAs (PubMed : 25375833). Plays an important role in regulating the growth of lipid droplets which are storage organelles at the center of lipid and energy homeostasis (PubMed : 26946540, PubMed : 31548309). Positively regulates the differentiation and development of adipocytes (By similarity).
See full target information CDS1
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Product promise

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