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AB188072

Anti-Cdx1 antibody

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(2 Publications)

Rabbit Polyclonal CDX1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CDX1 aa 1-50.

View Alternative Names

Homeobox protein CDX-1, Caudal-type homeobox protein 1, CDX1

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cdx1 antibody (AB188072)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cdx1 antibody (AB188072)

Immunohistochemical analysis of paraffin-embedded Human rectum tissue labeling Cdx1 with ab188072 at 1/50 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human CDX1 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

P47902

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Cdx1 also known as Caudal type homeobox 1 is a transcription factor with a molecular mass of approximately 32 kDa. This protein plays a significant role in the regulation of gene expression during embryonic development. Cdx1 mainly expresses in the intestinal epithelium and to some extent in the colon and rectum. It binds to specific DNA sequences influencing the expression of various genes related to development and differentiation.
Biological function summary

Regulating gene expression during development Cdx1 is important for maintaining the identity and function of intestinal cells. It does not operate on its own but is part of a complex network of transcription factors guiding the positional development and morphogenesis of the intestinal tract. This protein contributes to the proper development and specialization of tissues along the anterior-posterior axis of embryonic structures.

Pathways

Cdx1 interacts with several factors that make it an integral part of key developmental pathways like the Wnt signaling pathway and the Hox gene regulatory network. These pathways influence cellular differentiation and tissue patterning. In these pathways Cdx1 connects with other proteins such as beta-catenin and Hox genes cooperating in the spatial configuration of cellular structures during embryogenesis and adult tissue maintenance.

Cdx1 has been linked to colorectal cancer and other gut-related disorders due to its role in cell differentiation and proliferation. Abnormal Cdx1 expression leads to deregulated growth in intestinal epithelial cells contributing to oncogenesis. It interacts with other proteins involved in these disorders such as APC and p53 which can exacerbate or modulate the disease progression through disrupted signal pathways and altered cellular homeostasis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a role in transcriptional regulation (PubMed : 24623306). Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells (PubMed : 24623306). Binds to the PRKD1 promoter in colorectal cancer (CRC) cells (PubMed : 24623306). Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA (PubMed : 28473536).
See full target information CDX1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Experimental dermatology 31:330-340 PubMed34657330

2021

Naked (N) mutant mice carry a nonsense mutation in the homeobox of Hoxc13.

Applications

Unspecified application

Species

Unspecified reactive species

Carlos J Perez,Lars Mecklenburg,Almudena Fernandez,Marta Cantero,Tiago Antonio de Souza,Kevin Lin,Sharon Y R Dent,Lluis Montoliu,Alexander Awgulewitsch,Fernando Benavides

Human pathology 90:70-79 PubMed31121192

2019

CDX2 and Muc2 immunohistochemistry as prognostic markers in stage II colon cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Matthew J Cecchini,Joanna C Walsh,Jeremy Parfitt,Subrata Chakrabarti,Rohann J Correa,Mary J MacKenzie,David K Driman
View all publications
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Product promise

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