Anti-Cdx1 antibody [EPR4819(2)] - BSA and Azide free

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Cdx1 also known as Caudal type homeobox 1 is a transcription factor with a molecular mass of approximately 32 kDa. This protein plays a significant role in the regulation of gene expression during embryonic development. Cdx1 mainly expresses in the intestinal epithelium and to some extent in the colon and rectum. It binds to specific DNA sequences influencing the expression of various genes related to development and differentiation.

Biological function summary

Regulating gene expression during development Cdx1 is important for maintaining the identity and function of intestinal cells. It does not operate on its own but is part of a complex network of transcription factors guiding the positional development and morphogenesis of the intestinal tract. This protein contributes to the proper development and specialization of tissues along the anterior-posterior axis of embryonic structures.

Pathways

Cdx1 interacts with several factors that make it an integral part of key developmental pathways like the Wnt signaling pathway and the Hox gene regulatory network. These pathways influence cellular differentiation and tissue patterning. In these pathways Cdx1 connects with other proteins such as beta-catenin and Hox genes cooperating in the spatial configuration of cellular structures during embryogenesis and adult tissue maintenance.

Associated diseases and disorders

Cdx1 has been linked to colorectal cancer and other gut-related disorders due to its role in cell differentiation and proliferation. Abnormal Cdx1 expression leads to deregulated growth in intestinal epithelial cells contributing to oncogenesis. It interacts with other proteins involved in these disorders such as APC and p53 which can exacerbate or modulate the disease progression through disrupted signal pathways and altered cellular homeostasis.