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AB232696

Anti-CEACAM7 antibody

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(1 Publication)

Rabbit Polyclonal CEACAM7 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CEACAM7 aa 100-250.

View Alternative Names

CGM2, CEACAM7, Cell adhesion molecule CEACAM7, Carcinoembryonic antigen CGM2, Carcinoembryonic antigen-related cell adhesion molecule 7, CEA cell adhesion molecule 7

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CEACAM7 antibody (AB232696)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CEACAM7 antibody (AB232696)

Paraffin-embedded human colorectal cancer tissue stained for CEACAM7 using ab232696 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CEACAM7 antibody (AB232696)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CEACAM7 antibody (AB232696)

Formalin-fixed, paraffin-embedded human stomach cancer tissue stained for CEACAM7 using ab232696 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Western blot - Anti-CEACAM7 antibody (AB232696)
  • WB

Supplier Data

Western blot - Anti-CEACAM7 antibody (AB232696)

All lanes:

Western blot - Anti-CEACAM7 antibody (ab232696) at 2 µg/mL

All lanes:

Human serum

Predicted band size: 29 kDa

false

Western blot - Anti-CEACAM7 antibody (AB232696)
  • WB

Supplier Data

Western blot - Anti-CEACAM7 antibody (AB232696)

All lanes:

Western blot - Anti-CEACAM7 antibody (ab232696) at 2 µg/mL

All lanes:

Recombinant human CEACAM7 protein

Predicted band size: 29 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human CEACAM7 aa 100-250. The exact immunogen used to generate this antibody is proprietary information.

Q14002

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab232696 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 55.77% Glycerol (glycerin, glycerine), 44.12% PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The carcinoembryonic antigen-related cell adhesion molecule 7 (CEACAM7) also known by its gene name BAC2 is a glycosylated protein that has an approximate mass of 29 kDa. CEACAM7 belongs to the CEA family of proteins which are part of the immunoglobulin superfamily. This protein is mainly expressed on epithelial cells particularly in colon and rectum tissues as well as in normal and cancerous tissues of the colon epithelium. Expression is often downregulated in malignant transformation indicating alterations during cancer progression.
Biological function summary

The role of CEACAM7 involves cell adhesion processes and intercellular signaling. It functions as a calcium-independent cell adhesion molecule by mediating homophilic binding contributing to the maintenance of tissue architecture and stability. Although CEACAM7 does not typically form complexes with other proteins its interactions are critical for maintaining epithelial cell integrity. These interactions affect how cells communicate and can influence cell growth and differentiation.

Pathways

CEACAM7 is involved in regulating cell adhesion and immune response pathways. The protein contributes to the homophilic intercellular adhesion mediated by other members of the CEACAM family such as CEACAM1 and CEACAM6. These interactions scaffold the communication between cells affecting both adhesion and immune response mechanisms. Although the protein’s role in the pathways is not as well-characterized as other family members its alteration can influence downstream effects making it an interesting target for further pathway analysis.

CEACAM7 alterations have associations with colorectal cancer and inflammatory bowel disease (IBD). In colorectal cancer the downregulation of CEACAM7 correlates with tumor progression and poor prognosis whereas in IBD its expression might contribute towards the dysregulation of epithelial barriers. Through these conditions interactions with CEACAM1 and CEACAM6 signify how changes in the CEACAM family can have broader impacts on disease progression and manifestation. Understanding these interactions opens potential avenues for therapeutic intervention targeting CEACAM7 in related conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information CEACAM7
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 14:3392 PubMed37296100

2023

A multicentric consortium study demonstrates that dimethylarginine dimethylaminohydrolase 2 is not a dimethylarginine dimethylaminohydrolase.

Applications

Unspecified application

Species

Unspecified reactive species

Vinitha N Ragavan,Pramod C Nair,Natalia Jarzebska,Ramcharan Singh Angom,Luana Ruta,Elisa Bianconi,Silvia Grottelli,Natalia D Tararova,Daniel Ryazanskiy,Steven R Lentz,Sara Tommasi,Jens Martens-Lobenhoffer,Toshiko Suzuki-Yamamoto,Masumi Kimoto,Elena Rubets,Sarah Chau,Yingjie Chen,Xinli Hu,Nadine Bernhardt,Peter M Spieth,Norbert Weiss,Stefan R Bornstein,Debabrata Mukhopadhyay,Stefanie M Bode-Böger,Renke Maas,Ying Wang,Antonio Macchiarulo,Arduino A Mangoni,Barbara Cellini,Roman N Rodionov
View all publications
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