AB26281

Anti-CEACAM7 antibody [BAC2]

Name: Anti-CEACAM7 antibody [BAC2] (ab26281) | Abcam
Brand: Abcam Limited
SKU: AB26281
Price: 450 USD
Availability: InStock
Rating: 4 (1 reviews)

(1 Review)

(5 Publications)

Mouse Monoclonal CEACAM7 antibody. Suitable for Flow Cyt, ELISA, IHC-P, IHC-Fr and reacts with Transfected cell line, Human samples. Cited in 5 publications. Immunogen corresponding to Protein within Human CEACAM7.

View Alternative Names

CGM2, CEACAM7, Cell adhesion molecule CEACAM7, Carcinoembryonic antigen CGM2, Carcinoembryonic antigen-related cell adhesion molecule 7, CEA cell adhesion molecule 7

1 Images

Flow Cytometry - Anti-CEACAM7 antibody [BAC2] (AB26281)

Flow Cyt

Supplier Data

Flow Cytometry - Anti-CEACAM7 antibody [BAC2] (AB26281)

Members of the CEACAM family were expressed on BOSC cells after transient transfection with expression vectors containing either the cDNA of CEACAM1, 5, 6, 7, 8 or a recombinant trans-membrane-anchored PSG1 fusion protein. Recognition of CEACAM3, CEACAM4 and PSG1 was tested on stably transfected HeLa (CEACAM3, PSG) and CHO cells (CEACAM4), respectively. Expression of the constructs was confirmed.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

BAC2

Isotype

IgG1

Carrier free

Reacts with

Human

Applications

Flow Cyt, IHC-Fr, ELISA, IHC-P

applications

Immunogen

Protein within Human CEACAM7. The exact immunogen used to generate this antibody is proprietary information.

Q14002

Specificity

ab26281 recognizes exclusively CEACAM7 transiently expressed on the cell surface of transfected BOSC23 cells. It can be used to distinguish CEACAM7 from all other CEACAM and probably all pregnancy-specific glycoprotein molecules, namely CEACAM1 (BGP/CD66a), CEACAM3 (CGM1/CD66d), CEACAM4 (CGM7), CEACAM6 (NCA/CD66c), CEACAM7 (CGM2), CEACAM8 (CGM6/CD66b) and PSG1 (CD66f) based on its reactivity pattern with stable and transiently transfected mammalian cells expressing individual CEA family members.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<a href='/en-us/products/primary-antibodies/mouse-igg1-kappa-monoclonal-15-6e10a7-isotype-control-ab170190'>ab170190</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" }, "Transfected cell line": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "ELISA-species-checked": "notRecommended", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "IHCFr-species-checked": "notRecommended", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Storage buffer

pH: 7.2 Preservative: 0.01% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The carcinoembryonic antigen-related cell adhesion molecule 7 (CEACAM7) also known by its gene name BAC2 is a glycosylated protein that has an approximate mass of 29 kDa. CEACAM7 belongs to the CEA family of proteins which are part of the immunoglobulin superfamily. This protein is mainly expressed on epithelial cells particularly in colon and rectum tissues as well as in normal and cancerous tissues of the colon epithelium. Expression is often downregulated in malignant transformation indicating alterations during cancer progression.

Biological function summary

The role of CEACAM7 involves cell adhesion processes and intercellular signaling. It functions as a calcium-independent cell adhesion molecule by mediating homophilic binding contributing to the maintenance of tissue architecture and stability. Although CEACAM7 does not typically form complexes with other proteins its interactions are critical for maintaining epithelial cell integrity. These interactions affect how cells communicate and can influence cell growth and differentiation.

Pathways

CEACAM7 is involved in regulating cell adhesion and immune response pathways. The protein contributes to the homophilic intercellular adhesion mediated by other members of the CEACAM family such as CEACAM1 and CEACAM6. These interactions scaffold the communication between cells affecting both adhesion and immune response mechanisms. Although the protein’s role in the pathways is not as well-characterized as other family members its alteration can influence downstream effects making it an interesting target for further pathway analysis.

CEACAM7 alterations have associations with colorectal cancer and inflammatory bowel disease (IBD). In colorectal cancer the downregulation of CEACAM7 correlates with tumor progression and poor prognosis whereas in IBD its expression might contribute towards the dysregulation of epithelial barriers. Through these conditions interactions with CEACAM1 and CEACAM6 signify how changes in the CEACAM family can have broader impacts on disease progression and manifestation. Understanding these interactions opens potential avenues for therapeutic intervention targeting CEACAM7 in related conditions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

See full target information CEACAM7

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

American journal of physiology. Cell physiology 318:C83-C93 PubMed31644306

2019

Nucleolin mediates the binding of cancer cells to L-selectin under conditions of lymphodynamic shear stress.

Applications

Unspecified application

Species

Unspecified reactive species

Tovë M Goldson,Kevin L Turner,Yinan Huang,Grady E Carlson,Emily G Caggiano,Andres F Oberhauser,Susan M Fennewald,Monica M Burdick,Vicente A Resto

British journal of cancer 107:1745-53 PubMed23099808

2012

Carcinoembryonic antigen-related cell adhesion molecules as surrogate markers for EGFR inhibitor sensitivity in human lung adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

M Kobayashi,Y Miki,M Ebina,K Abe,K Mori,S Narumi,T Suzuki,I Sato,M Maemondo,C Endo,A Inoue,H Kumamoto,T Kondo,H Yamada-Okabe,T Nukiwa,H Sasano

World journal of surgical oncology 9:172 PubMed22195770

2011

Dynamic expression of CEACAM7 in precursor lesions of gastric carcinoma and its prognostic value in combination with CEA.

Applications

IHC-P

Species

Human

Jinfeng Zhou,Liyun Zhang,Yong Gu,Kai Li,Yongzhan Nie,Daiming Fan,Yichao Feng

Molecular & cellular proteomics : MCP 8:1697-707 PubMed19377061

2009

The prevalence and nature of glycan alterations on specific proteins in pancreatic cancer patients revealed using antibody-lectin sandwich arrays.

Applications

Unspecified application

Species

Unspecified reactive species

Tingting Yue,Irwin J Goldstein,Michael A Hollingsworth,Karen Kaul,Randall E Brand,Brian B Haab

The Journal of biological chemistry 283:15647-55 PubMed18375392

2008

Carcinoembryonic antigen and CD44 variant isoforms cooperate to mediate colon carcinoma cell adhesion to E- and L-selectin in shear flow.

Applications

Flow Cyt

Species

Human

Susan N Thomas,Fei Zhu,Ronald L Schnaar,Christina S Alves,Konstantinos Konstantopoulos

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CEACAM7 antibody [BAC2]

Flow Cytometry - Anti-CEACAM7 antibody [BAC2] (AB26281)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (5)

Product promise