AB74045

Anti-CEBPG antibody

Name: Anti-CEBPG antibody (ab74045) | Abcam
Brand: Abcam Limited
SKU: AB74045
Price: 480 USD
Availability: InStock

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(5 Publications)

Rabbit Polyclonal CEBPG antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human CEBPG.

View Alternative Names

CCAAT/enhancer-binding protein gamma, C/EBP gamma, CEBPG

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CEBPG antibody (AB74045)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CEBPG antibody (AB74045)

Immunohistochemistry analysis of paraffin-embedded human heart tissue using ab74045, at 1/50 dilution, in the presence (right panel) or absence (left panel) of immunising peptide.

Unknown

Western blot - Anti-CEBPG antibody (AB74045)

All lanes:

Western blot - Anti-CEBPG antibody (ab74045) at 1/500 dilution

Lane 1:

Extracts from RAW264.7 cells at 5 µg

Lane 2:

Extracts from RAW264.7 cells at 5 µg with immunising peptide

Predicted band size: 16 kDa

Observed band size: 21 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human CEBPG. The exact immunogen used to generate this antibody is proprietary information.

P53567

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/100", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Stable for 12 months at -20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The CCAAT/enhancer-binding protein gamma (CEBPG) also known as C/EBPγ is a transcription factor that regulates gene expression by binding to DNA. It weighs approximately 18-19 kDa. CEBPG is expressed in various tissues including liver lung and adipose tissue. This broad expression pattern suggests CEBPG interacts with cellular processes across different physiological contexts.

Biological function summary

CEBPG serves as a regulator of cellular differentiation and proliferation. It often forms dimers with other C/EBP family members enhancing its DNA binding capacity and functional diversity. By participating in these complexes CEBPG helps maintain homeostasis and regulate immune responses. Its activity is vital for controlling genes involved in metabolism and inflammation.

Pathways

CEBPG functions within the MAPK signaling pathway and the IL-6 signaling pathway. In the MAPK pathway it interacts with proteins such as JNK thereby influencing cell growth and apoptosis. In the IL-6 pathway CEBPG contributes to the modulation of the inflammatory response. This involvement makes CEBPG a significant player in immune function and cellular stress responses.

CEBPG has relevance to conditions like leukemia and chronic inflammatory diseases. Alterations in CEBPG expression or function can disrupt normal cell cycle control linking it to oncogenesis. In leukemia CEBPG interacts with proteins such as CEBPA influencing hematopoietic stem cell differentiation. In chronic inflammatory diseases CEBPG’s role in regulating inflammatory pathways can exacerbate or mitigate disease symptoms.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Transcription factor that binds to the promoter and the enhancer regions of target genes. Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene (PubMed : 7665092). Binds to the promoter and the enhancer of the immunoglobulin heavy chain. Binds to GPE1, a cis-acting element in the G-CSF gene promoter.

See full target information CEBPG

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Molecular cancer therapeutics 21:1632-1644 PubMed36121385

2022

Anticancer Activity of ST101, A Novel Antagonist of CCAAT/Enhancer Binding Protein β.

Applications

Unspecified application

Species

Unspecified reactive species

Emad Darvishi,Lila Ghamsari,Siok F Leong,Ricardo Ramirez,Mark Koester,Erin Gallagher,Miao Yu,Jody M Mason,Gene Merutka,Barry J Kappel,Jim A Rotolo

Nucleic acids research 50:7298-7309 PubMed35801910

2022

Systemic approaches using single cell transcriptome reveal that C/EBPγ regulates autophagy under amino acid starved condition.

Applications

Unspecified application

Species

Unspecified reactive species

Dongha Kim,Junil Kim,Young Suk Yu,Yong Ryoul Kim,Sung Hee Baek,Kyoung-Jae Won

The Journal of biological chemistry 295:2787-2803 PubMed31953319

2020

Activating transcription factor 4 (ATF4) promotes skeletal muscle atrophy by forming a heterodimer with the transcriptional regulator C/EBPβ.

Applications

Unspecified application

Species

Unspecified reactive species

Scott M Ebert,Steven A Bullard,Nathan Basisty,George R Marcotte,Zachary P Skopec,Jason M Dierdorff,Asma Al-Zougbi,Kristin C Tomcheck,Austin D DeLau,Jacob A Rathmacher,Sue C Bodine,Birgit Schilling,Christopher M Adams

Molecular cancer research : MCR 18:216-228 PubMed31676720

2019

Dominant-Negative ATF5 Compromises Cancer Cell Survival by Targeting CEBPB and CEBPD.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaotian Sun,Parvaneh Jefferson,Qing Zhou,James M Angelastro,Lloyd A Greene

Oncotarget 8:114195-114209 PubMed29371979

2017

ETV4 collaborates with Wnt/β-catenin signaling to alter cell cycle activity and promote tumor aggressiveness in gastrointestinal stromal tumor.

Applications

Unspecified application

Species

Unspecified reactive species

Shan Zeng,Adrian M Seifert,Jennifer Q Zhang,Teresa S Kim,Timothy G Bowler,Michael J Cavnar,Benjamin D Medina,Gerardo A Vitiello,Ferdinand Rossi,Jennifer K Loo,Nesteene J Param,Ronald P DeMatteo

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CEBPG antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CEBPG antibody (AB74045)

Western blot - Anti-CEBPG antibody (AB74045)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Complementary Products

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (5)

Product promise