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AB225991

Anti-Cell Division Protein FtsZ antibody

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Rabbit Polyclonal Cell Division Protein FtsZ antibody. Suitable for WB and reacts with Recombinant full length protein - Wolbachia pipientis samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Wolbachia pipientis ftsZ.

View Alternative Names

Cell division protein FtsZ, ftsZ

1 Images
Western blot - Anti-Cell Division Protein FtsZ antibody (AB225991)
  • WB

Supplier Data

Western blot - Anti-Cell Division Protein FtsZ antibody (AB225991)

All lanes:

Western blot - Anti-Cell Division Protein FtsZ antibody (ab225991) at 1/500 dilution

Lane 1:

Recombinant Wolbachia pipientis Cell division protein FtsZ protein 80 ng

Lane 2:

Recombinant Wolbachia pipientis Cell division protein FtsZ protein 40 ng

Lane 3:

Recombinant Wolbachia pipientis Cell division protein FtsZ protein 20 ng

Lane 4:

Recombinant Wolbachia pipientis Cell division protein FtsZ protein 10 ng

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Wolbachia pipientis

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Wolbachia pipientis ftsZ.

P50907

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Recombinant full length protein - Wolbachia pipientis": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p>Only tested with recombinant protein. No data available for endogenous protein.</p>" }, "Wolbachia pipientis": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Cell Division Protein FtsZ also known as FtsZ protein is an important bacterial cytoskeletal protein with a mass of around 40 kDa. It is expressed in most bacteria and some archaea where it plays an essential role in prokaryotic cell division. Mechanically FtsZ assembles into a ring-like structure at the future site of cell division known as the Z-ring. This protein acts as a scaffold and recruits other cellular components necessary for the formation of a septum leading to the successful constriction of the cells and their eventual division.
Biological function summary

Cells rely on FtsZ for defining the site of cytokinesis during cell division. FtsZ functions as a vital element of the divisome complex which is a group of proteins that coordinate the division process in bacteria. Due to its GTPase activity FtsZ hydrolyzes GTP providing the energy required for its polymerization and depolymerization which are important processes in the tightening of the Z-ring. Through this dynamic behavior FtsZ orchestrates the changes in the bacterial cell membrane necessary to create two separate daughter cells.

Pathways

FtsZ participates integrally in bacterial cytokinesis pathways and cellular stress response pathways. It holds a pivotal position in the bacterial cell cycle regulation coordinating its actions with proteins such as ZipA and FtsA essential for the initiation of division. These proteins interact directly with FtsZ forming a stable and dynamic connection important for the accurate timing of cell division events within the cell.

Dysfunction in pathways involving FtsZ can contribute to the failure in proper bacterial cell division which may be exploited for antibacterial drug development. Targeting FtsZ in pathogenic bacteria is a promising strategy for novel antibiotic treatment especially since it has no direct homologs in eukaryotes. FtsZ shares relationships with proteins involved in drug resistance mechanisms such as mutations in other division proteins like FtsI causing further complications in treating bacterial infections. Understanding these connections remains significant for developing therapies against resistant bacterial strains.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
See full target information ftsZ
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Product promise

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