Rabbit Polyclonal Cellular Apoptosis Susceptibility/CSE1L antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Rat, Human samples. Cited in 11 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CSE1L aa 200-450.
Images
Publications
- Developmental cell 57:1712-1727.e92022A ROS-dependent mechanism promotes CDK2 phosphorylation to drive progression through S phase.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDilyana Georgieva Kirova,Kristyna Judasova,Julia Vorhauser,Thomas Zerjatke,Jacky Kieran Leung,Ingmar Glauche,Jörg MansfeldPubMed 35809563
- Communications biology 5:4832022SARS-CoV-2 ORF6 disrupts nucleocytoplasmic trafficking to advance viral replication.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYoichi Miyamoto,Yumi Itoh,Tatsuya Suzuki,Tomohisa Tanaka,Yusuke Sakai,Masaru Koido,Chiaki Hata,Cai-Xia Wang,Mayumi Otani,Kohji Moriishi,Taro Tachibana,Yoichiro Kamatani,Yoshihiro Yoneda,Toru Okamoto,Masahiro OkaPubMed 35590097
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7
Preservative: 0.025% Proclin 300
Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine)- Form
Liquid
- Clonality
Polyclonal
Immunogen
- Recombinant Fragment Protein within Human CSE1L aa 200-450. The exact immunogen used to generate this antibody is proprietary information. Database link P55060
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Reactivity data
Select an application| WB | IHC-P | ICC/IF | |
|---|---|---|---|
| Human | Tested | Tested | Tested |
| Mouse | Tested | Expected | Expected |
| Rat | Tested | Expected | Expected |
| Cow | Predicted | Predicted | Predicted |
| Zebrafish | Predicted | Predicted | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/1000 - 1/20000 | Notes - |
Species Rat | Dilution info 1/1000 - 1/20000 | Notes - |
Species Human | Dilution info 1/1000 - 1/20000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Cow, Zebrafish | Dilution info - | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100 - 1/2000 | Notes Suggested antigen retrieval using heat mediated 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH 8.0) |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info Use at an assay dependent concentration. | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Cow, Zebrafish | Dilution info - | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100 - 1/1000 | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info Use at an assay dependent concentration. | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Cow, Zebrafish | Dilution info - | Notes - |
Associated Products
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Target data
Function
Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Alternative names
Exportin-2, Exp2, Cellular apoptosis susceptibility protein, Chromosome segregation 1-like protein, Importin-alpha re-exporter, XPO2, CAS, CSE1L
Recommended products
Rabbit Polyclonal Cellular Apoptosis Susceptibility/CSE1L antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Rat, Human samples. Cited in 11 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CSE1L aa 200-450.
Alternative names
Exportin-2, Exp2, Cellular apoptosis susceptibility protein, Chromosome segregation 1-like protein, Importin-alpha re-exporter, XPO2, CAS, CSE1L
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7
Preservative: 0.025% Proclin 300
Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine)- Form
Liquid
- Clonality
Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human CSE1L aa 200-450. The exact immunogen used to generate this antibody is proprietary information. Database link P55060
- Purification technique
Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage duration
1-2 weeks
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
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5 product images
Immunocytochemistry/ Immunofluorescence - Anti-Cellular Apoptosis Susceptibility/CSE1L antibody (ab96755)
HeLa cells stained for CSE1L (green) using ab96755 at 1/2000 dilution in ICC/IF.
Western blot - Anti-Cellular Apoptosis Susceptibility/CSE1L antibody (ab96755)
7.5% SDS-PAGE
All lanes: Western blot - Anti-Cellular Apoptosis Susceptibility/CSE1L antibody (ab96755) at 1/10000 dilution
Lane 1: PC-12 whole cell lysate at 30 µg
Lane 2: Rat2 whole cell lysate at 30 µg
Predicted band size: 110 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cellular Apoptosis Susceptibility/CSE1L antibody (ab96755)
Immunohistochemical analysis of paraffin-embedded Cal27 Xenograft using ab96755 at 1/500 dilution.
Western blot - Anti-Cellular Apoptosis Susceptibility/CSE1L antibody (ab96755)
All lanes: Western blot - Anti-Cellular Apoptosis Susceptibility/CSE1L antibody (ab96755) at 1/1000 dilution
Lane 1: HEK-293T whole cell lysate at 30 µg
Lane 2: A431 whole cell lysate at 30 µg
Lane 3: H1299 whole cell lysate at 30 µg
Lane 4: HeLa whole cell lysate at 30 µg
Predicted band size: 110 kDa
Western blot - Anti-Cellular Apoptosis Susceptibility/CSE1L antibody (ab96755)
7.5% SDS-PAGE
All lanes: Western blot - Anti-Cellular Apoptosis Susceptibility/CSE1L antibody (ab96755) at 1/10000 dilution
Lane 1: NIH/3T3 whole cell lysate at 30 µg
Lane 2: JC whole cell lysate at 30 µg
Lane 3: BCL-1 whole cell lysate at 30 µg
Lane 4: C2C12 whole cell lysate at 30 µg
Predicted band size: 110 kDa
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