Rabbit Polyclonal Cellular Apoptosis Susceptibility/CSE1L antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Rat, Human samples. Cited in 11 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CSE1L aa 200-450.
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- Developmental cell 57:1712-1727.e92022A ROS-dependent mechanism promotes CDK2 phosphorylation to drive progression through S phase.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDilyana Georgieva Kirova,Kristyna Judasova,Julia Vorhauser,Thomas Zerjatke,Jacky Kieran Leung,Ingmar Glauche,Jörg MansfeldPubMed 35809563
- Communications biology 5:4832022SARS-CoV-2 ORF6 disrupts nucleocytoplasmic trafficking to advance viral replication.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYoichi Miyamoto,Yumi Itoh,Tatsuya Suzuki,Tomohisa Tanaka,Yusuke Sakai,Masaru Koido,Chiaki Hata,Cai-Xia Wang,Mayumi Otani,Kohji Moriishi,Taro Tachibana,Yoichiro Kamatani,Yoshihiro Yoneda,Toru Okamoto,Masahiro OkaPubMed 35590097
- Journal of cell science 134:2021On the asymmetric partitioning of nucleocytoplasmic transport - recent insights and open questions.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJoanna Kalita,Larisa E Kapinos,Roderick Y H LimPubMed 33912945
- Frontiers in oncology 11:6609552021FLVCR1 Predicts Poor Prognosis and Promotes Malignant Phenotype in Esophageal Squamous Cell Carcinoma Upregulating CSE1L.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSuna Zhou,Mingxin Zhang,Chao Zhou,Yinnan Meng,Haihua Yang,Wenguang YePubMed 33842377
- Cancer research 81:1853-18672021Fragmentation of Small-Cell Lung Cancer Regulatory States in Heterotypic Microenvironments.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDylan L Schaff,Shambhavi Singh,Kee-Beom Kim,Matthew D Sutcliffe,Kwon-Sik Park,Kevin A JanesPubMed 33531375
- Scientific reports 10:186402020Transportin-2 plays a critical role in nucleocytoplasmic shuttling of oestrogen receptor-α.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTetsuji Moriyama,Yoshihiro Yoneda,Masahiro Oka,Masami YamadaPubMed 33122699
- Life sciences 254:1176992020LncRNA Oprm1 overexpression attenuates myocardial ischemia/reperfusion injury by increasing endogenous hydrogen sulfide via Oprm1/miR-30b-5p/CSE axis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiaomin Hu et. al.PubMed 32437793
- Aging 10:2062-20782018LncRNA BANCR promotes tumorigenesis and enhances adriamycin resistance in colorectal cancer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSiping Ma,Dongxiang Yang,Yanlong Liu,Yongpeng Wang,Tao Lin,Yanxi Li,Shihua Yang,Wanchuan Zhang,Rui ZhangPubMed 30144787
- Cell chemical biology 24:1416-1427.e52017Multiplexed Thiol Reactivity Profiling for Target Discovery of Electrophilic Natural Products.Applications:Unspecified applicationReactive species:Unspecified reactive speciesCaiping Tian et. al.PubMed 28988947
- The Journal of neuroscience : the official journal 37:8830-88442017Calpain-Dependent Degradation of Nucleoporins Contributes to Motor Neuron Death in a Mouse Model of Chronic Excitotoxicity.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKaori Sugiyama et. al.PubMed 28821644
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.025% Proclin 300
Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human CSE1L aa 200-450. The exact immunogen used to generate this antibody is proprietary information. Database link P55060
Consider this alternative
Reactivity data
Select an application| WB | IHC-P | ICC/IF | |
|---|---|---|---|
| Human | Tested | Tested | Tested |
| Mouse | Tested | Expected | Expected |
| Rat | Tested | Expected | Expected |
| Cow | Predicted | Predicted | Predicted |
| Zebrafish | Predicted | Predicted | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/1000 - 1/20000 | Notes - |
Species Rat | Dilution info 1/1000 - 1/20000 | Notes - |
Species Human | Dilution info 1/1000 - 1/20000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Cow, Zebrafish | Dilution info - | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100 - 1/2000 | Notes Suggested antigen retrieval using heat mediated 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH 8.0) |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info Use at an assay dependent concentration. | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Cow, Zebrafish | Dilution info - | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100 - 1/1000 | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info Use at an assay dependent concentration. | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Cow, Zebrafish | Dilution info - | Notes - |
Associated Products
Select an associated product type
3 products for Alternative Product
Target data
Function
Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Alternative names
CAS, XPO2, CSE1L, Exportin-2, Exp2, Cellular apoptosis susceptibility protein, Chromosome segregation 1-like protein, Importin-alpha re-exporter
Recommended products
Rabbit Polyclonal Cellular Apoptosis Susceptibility/CSE1L antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Rat, Human samples. Cited in 11 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CSE1L aa 200-450.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.025% Proclin 300
Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human CSE1L aa 200-450. The exact immunogen used to generate this antibody is proprietary information. Database link P55060
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
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5 product images
Immunocytochemistry/ Immunofluorescence - Anti-Cellular Apoptosis Susceptibility/CSE1L antibody (ab96755)
HeLa cells stained for CSE1L (green) using ab96755 at 1/2000 dilution in ICC/IF.
Western blot - Anti-Cellular Apoptosis Susceptibility/CSE1L antibody (ab96755)
7.5% SDS-PAGE
All lanes: Western blot - Anti-Cellular Apoptosis Susceptibility/CSE1L antibody (ab96755) at 1/10000 dilution
Lane 1: PC-12 whole cell lysate at 30 µg
Lane 2: Rat2 whole cell lysate at 30 µg
Predicted band size: 110 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cellular Apoptosis Susceptibility/CSE1L antibody (ab96755)
Immunohistochemical analysis of paraffin-embedded Cal27 Xenograft using ab96755 at 1/500 dilution.
Western blot - Anti-Cellular Apoptosis Susceptibility/CSE1L antibody (ab96755)
All lanes: Western blot - Anti-Cellular Apoptosis Susceptibility/CSE1L antibody (ab96755) at 1/1000 dilution
Lane 1: HEK-293T whole cell lysate at 30 µg
Lane 2: A431 whole cell lysate at 30 µg
Lane 3: H1299 whole cell lysate at 30 µg
Lane 4: HeLa whole cell lysate at 30 µg
Predicted band size: 110 kDa
Western blot - Anti-Cellular Apoptosis Susceptibility/CSE1L antibody (ab96755)
7.5% SDS-PAGE
All lanes: Western blot - Anti-Cellular Apoptosis Susceptibility/CSE1L antibody (ab96755) at 1/10000 dilution
Lane 1: NIH/3T3 whole cell lysate at 30 µg
Lane 2: JC whole cell lysate at 30 µg
Lane 3: BCL-1 whole cell lysate at 30 µg
Lane 4: C2C12 whole cell lysate at 30 µg
Predicted band size: 110 kDa
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