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AB189180

Anti-Cellular Apoptosis Susceptibility/CSE1L antibody - N-terminal

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(2 Publications)

Rabbit Polyclonal Cellular Apoptosis Susceptibility/CSE1L antibody. N-terminal. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human CSE1L aa 1-50.

View Alternative Names

CAS, XPO2, CSE1L, Exportin-2, Exp2, Cellular apoptosis susceptibility protein, Chromosome segregation 1-like protein, Importin-alpha re-exporter

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-Cellular Apoptosis Susceptibility/CSE1L antibody - N-terminal (AB189180)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Cellular Apoptosis Susceptibility/CSE1L antibody - N-terminal (AB189180)

Immunofluorescent analysis of HeLa cells labeling Exportin 2 with ab189180 at 1/100 dilution in the presence (right panel) or absence (left panel) of immunizing peptide.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cellular Apoptosis Susceptibility/CSE1L antibody - N-terminal (AB189180)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cellular Apoptosis Susceptibility/CSE1L antibody - N-terminal (AB189180)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human testis tissue labeling Cellular Apoptosis Susceptibility/CSE1L with ab189180 at 10 μg/ml.

Western blot - Anti-Cellular Apoptosis Susceptibility/CSE1L antibody - N-terminal (AB189180)
  • WB

Supplier Data

Western blot - Anti-Cellular Apoptosis Susceptibility/CSE1L antibody - N-terminal (AB189180)

All lanes:

Western blot - Anti-Cellular Apoptosis Susceptibility/CSE1L antibody - N-terminal (ab189180) at 1/500 dilution

Lane 1:

293 cell extract

Lane 2:

293 cell extract with immunizing peptide

Predicted band size: 110 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF, IHC-P

applications

Immunogen

Synthetic Peptide within Human CSE1L aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

P55060

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "10 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/500", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
See full target information CSE1L
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Nature chemical biology 18:698-705 PubMed35332331

2022

An infection-induced oxidation site regulates legumain processing and tumor growth.

Applications

Unspecified application

Species

Unspecified reactive species

Yekaterina Kovalyova,Daniel W Bak,Elizabeth M Gordon,Connie Fung,Jennifer H B Shuman,Timothy L Cover,Manuel R Amieva,Eranthie Weerapana,Stavroula K Hatzios

Microbiome 8:143 PubMed33008466

2020

β-glucan attenuates cognitive impairment via the gut-brain axis in diet-induced obese mice.

Applications

Unspecified application

Species

Unspecified reactive species

Hongli Shi,Yinghua Yu,Danhong Lin,Peng Zheng,Peng Zhang,Minmin Hu,Qiao Wang,Wei Pan,Xiaoying Yang,Tao Hu,Qianqian Li,Renxian Tang,Feng Zhou,Kuiyang Zheng,Xu-Feng Huang
View all publications
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Product promise

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