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AB196600

Anti-CELSR1 antibody

4

(2 Reviews)

|

(2 Publications)

Rabbit Polyclonal CELSR1 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human CELSR1.

View Alternative Names

CDHF9, FMI2, CELSR1, Cadherin EGF LAG seven-pass G-type receptor 1, Cadherin family member 9, Flamingo homolog 2, hFmi2

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-CELSR1 antibody (AB196600)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-CELSR1 antibody (AB196600)

Immunofluorescence analysis of MCF-7 cells, labeling CELSR1 with ab196600 at 1/100 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Synthetic Peptide within Human CELSR1. The exact immunogen used to generate this antibody is proprietary information.

Q9NYQ6

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/500", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS, 0.87% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CELSR1 also known as Cadherin EGF LAG seven-pass G-type receptor 1 is a member of the adhesion G-protein-coupled receptors family. Its molecular mass is approximately 350 kDa. The protein consists of several cadherin repeats and EGF-like domains playing a critical role in cell signaling and adhesion. CELSR1 is mainly expressed in the central nervous system and certain epithelial tissues contributing significantly to cellular interactions and positioning during development.
Biological function summary

CELSR1 is an important component of the planar cell polarity (PCP) signaling pathway. It acts as a part of a receptor complex that is important for the regulation of cell orientation and coordinated tissue patterning. This protein through its interaction with other PCP components helps in establishing cellular asymmetry and polarity within tissues. CELSR1 regulates developmental processes in various tissues making it a significant player in embryogenesis and organogenesis.

Pathways

CELSR1 integrates into the non-canonical Wnt/PCP signaling pathway influencing cellular processes such as migration and polarity. It interacts closely with proteins like Frizzled and Dishevelled to propagate signaling within this pathway. Additionally CELSR1's functions are connected with the Flamingo cadherins variously affecting cellular alignment and directional movement important for functioning tissues and organs.

Defects in CELSR1 can lead to congenital malformations such as neural tube defects and craniorachischisis. The protein's altered expression or dysfunction is linked to cancer development especially in tumors where cell polarity and adhesion are disrupted. CELSR1's relationship with proteins like Vangl and Dishevelled in disease contexts highlights its role in maintaining cellular integrity and tissue homeostasis and when perturbed contributes to pathogenesis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor that may have an important role in cell/cell signaling during nervous system formation.
See full target information CELSR1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Leukemia & lymphoma 60:1697-1708 PubMed30570341

2018

Retinoic acid and 6-formylindolo(3,2-b)carbazole (FICZ) combination therapy reveals putative targets for enhancing response in non-APL AML.

Applications

Unspecified application

Species

Unspecified reactive species

Rodica P Bunaciu,Robert J MacDonald,Holly A Jensen,Feng Gao,Xin Wang,Lynn Johnson,Jeffrey D Varner,Andrew Yen

Journal of leukocyte biology 103:381-393 PubMed29345390

2018

Frontline Science: Wnt/β-catenin pathway promotes early engraftment of fetal hematopoietic stem/progenitor cells.

Applications

Unspecified application

Species

Unspecified reactive species

Edward O Kwarteng,Roxann Hétu-Arbour,Krista M Heinonen
View all publications
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