AB189045

Anti-CELSR2 antibody - N-terminal

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(1 Publication)

Rabbit Polyclonal CELSR2 antibody. N-terminal. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human CELSR2.

View Alternative Names

CDHF10, EGFL2, KIAA0279, MEGF3, CELSR2, Cadherin EGF LAG seven-pass G-type receptor 2, Cadherin family member 10, Epidermal growth factor-like protein 2, Flamingo homolog 3, Multiple epidermal growth factor-like domains protein 3, EGF-like protein 2, Multiple EGF-like domains protein 3

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CELSR2 antibody - N-terminal (AB189045)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CELSR2 antibody - N-terminal (AB189045)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human colon (epithelium) tissue labeling CELSR2 with ab189045 at 5 μg/ml.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CELSR2 antibody - N-terminal (AB189045)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain tissue labeling CELSR2 with ab189045 at 5 μg/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human CELSR2. The exact immunogen used to generate this antibody is proprietary information.

Q9HCU4

Specificity

BLAST analysis of the peptide immunogen showed no homology with other Human proteins.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "3-15 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rabbit": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CELSR2 also recognized as cadherin EGF LAG seven-pass G-type receptor 2 is a large approximately 300 kDa protein. It is a member of the cadherin superfamily and functions as a non-classical adhesion GPCR. CELSR2 mediates cell-cell contacts and is integral in maintaining tissue structure. The protein is widely expressed in the brain and across various tissues contributing to its essential role in tissue morphogenesis and cellular signaling.

Biological function summary

CELSR2 influences cell polarity and synaptic development. It plays a role in the planar cell polarity (PCP) signaling pathway. This protein is a part of large protein complexes that are responsible for regulating the orientation and spatial arrangement of cell structures. CELSR2 affects neuronal development and axonal guidance reflecting its significance in the complex neural networks.

Pathways

Research shows that CELSR2 is involved in PCP and Wnt signaling pathways. In these pathways CELSR2 interacts with key proteins such as Frizzled and Dishevelled. These interactions facilitate proper neighborhood cell function by modulating cytoskeletal arrangements and signal transduction processes that are necessary for effective communication and connectivity between cells.

CELSR2 has associations with neurodevelopmental disorders and cardiovascular diseases such as atherosclerosis. Studies show that variations in CELSR2 expression may correlate with lipid metabolism abnormalities influencing cholesterol levels and cardiovascular disease risk. It relates to proteins like SORT1 and APOB coming into play in the pathophysiology of these conditions which highlights its potential as a therapeutic target in managing related diseases.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Receptor that may have an important role in cell/cell signaling during nervous system formation.

See full target information CELSR2

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

EBioMedicine 48:130-142 PubMed31522982

2019

Knockdown of vimentin reduces mesenchymal phenotype of cholangiocytes in the Mdr2 mouse model of primary sclerosing cholangitis (PSC).

Applications

Unspecified application

Species

Unspecified reactive species

Tianhao Zhou,Konstantina Kyritsi,Nan Wu,Heather Francis,Zhihong Yang,Lixian Chen,April O'Brien,Lindsey Kennedy,Ludovica Ceci,Vik Meadows,Praveen Kusumanchi,Chaodong Wu,Leonardo Baiocchi,Nicholas J Skill,Romil Saxena,Amelia Sybenga,Linglin Xie,Suthat Liangpunsakul,Fanyin Meng,Gianfranco Alpini,Shannon Glaser

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CELSR2 antibody - N-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CELSR2 antibody - N-terminal (AB189045)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CELSR2 antibody - N-terminal (AB189045)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Product promise