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AB169514

Anti-CEMP1 antibody

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Mouse Polyclonal CEMP1 antibody. Carrier free. Suitable for WB and reacts with Transfected cell lysate - Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CEMP1.

View Alternative Names

Cementoblastoma-derived protein 1, Cementum protein 1, Cementum protein 23, CP-23, CEMP1

1 Images
Western blot - Anti-CEMP1 antibody (AB169514)
  • WB

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Western blot - Anti-CEMP1 antibody (AB169514)

All lanes:

Western blot - Anti-CEMP1 antibody (ab169514) at 1 µg/mL

Lane 1:

CEMP1 transfected lysate(27.17 KDa) at 15 µL

Lane 2:

Non-transfected lysate at 15 µL

Predicted band size: 26 kDa

false

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human CEMP1.

Q6PRD7

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: 99% PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CEMP1 also known as Cementum protein 1 is a protein with an approximate mass of 39 kDa. It localizes mainly in the cementum of teeth but is also found in the periodontal ligament. CEMP1 engages in the mineralization process of cementum an important tissue that provides support and stability to teeth by anchoring them to the jawbone. The expression of CEMP1 occurs in cementoblasts cells responsible for generating and maintaining cementum.
Biological function summary

The function of CEMP1 in dental tissues extends beyond just promoting mineralization. It acts as a regulator of cell differentiation and proliferation which are critical stages in tissue development and repair. In the context of tooth development CEMP1 does not belong to a larger protein complex but interacts with the extracellular matrix to maintain the structural integrity of the periodontal tissues. This involvement highlights its importance in dental health.

Pathways

CEMP1 plays a role in signaling pathways related to osteogenesis and extracellular matrix organization. It interacts with molecular components in the Wnt signaling pathway an important pathway involved in bone formation and cell proliferation. CEMP1 also functions in tandem with proteins like osteopontin contributing to the control of mineral deposition and tissue homeostasis within the periodontium.

CEMP1's function offers important insights into conditions like periodontal disease and cleidocranial dysplasia. In periodontal disease where inflammation and destruction of supporting tooth tissues occur CEMP1's role in cementum integrity suggests it may influence disease progression. Additionally it may relate to collagen type I whose expression is important in maintaining the extracellular matrix affected in such disorders. Understanding CEMP1's interactions might offer potential therapeutic targets to manage these conditions and enhance periodontal regeneration.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May play a role in development of the periodontium which surrounds and supports the teeth by promoting the differentiation of multi-potent cells from the periodontal ligament into cementoblasts to form the cementum (PubMed : 17509525, PubMed : 21465469, PubMed : 21929512). Binds hydroxyapatite and may promote the biomineralization of the cementum (PubMed : 19393626). Also promotes cell proliferation (PubMed : 17509525, PubMed : 21929512, PubMed : 26011628).
See full target information CEMP1
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