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AB113076

Anti-CEND1 antibody [EPR3739]

5

(1 Review)

|

(6 Publications)

Rabbit Recombinant Monoclonal CEND1 antibody. Suitable for IHC-P, WB and reacts with Human, Mouse samples. Cited in 6 publications.

View Alternative Names

BM88, CEND1, Cell cycle exit and neuronal differentiation protein 1, BM88 antigen

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CEND1 antibody [EPR3739] (AB113076)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CEND1 antibody [EPR3739] (AB113076)

ab113076 at 1/500 dilution staining CEND1 in Praffin-embedded Human brain tissue by Immunohistochemistry.

Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CEND1 antibody [EPR3739] (AB113076)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CEND1 antibody [EPR3739] (AB113076)

ab113076 at 1/500 dilution staining CEND1 in Praffin-embedded Human glioma tissue by Immunohistochemistry.

Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Western blot - Anti-CEND1 antibody [EPR3739] (AB113076)
  • WB

Unknown

Western blot - Anti-CEND1 antibody [EPR3739] (AB113076)

All lanes:

Western blot - Anti-CEND1 antibody [EPR3739] (ab113076) at 1/10000 dilution

Lane 1:

Human fetal brain tissue lysate at 10 µg

Lane 2:

U-87 MG cell lysate at 10 µg

Lane 3:

Neuro-2a cell lysate at 10 µg

Predicted band size: 15 kDa

false

  • Carrier free

    Anti-CEND1 antibody [EPR3739] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR3739

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p>Heat up to 98 degrees C, below boiling, and then let cool for 10-20 min</p>", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/10000 - 1/50000", "WB-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/10000 - 1/50000", "WB-species-notes": "<p></p>" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Stable for 12 months at -20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CEND1 also known as cell cycle exit and neuronal differentiation 1 is a protein with a mass of approximately 16 kDa. Researchers have identified its expression specifically in neural precursor cells of the central nervous system. CEND1 plays a role in controlling neuronal differentiation by interacting with cell cycle regulators. This function highlights its importance in the development of the nervous system and its involvement in maintaining the balance between proliferation and differentiation in neurons.
Biological function summary

CEND1 facilitates neuronal outgrowth and maturation without forming part of a larger multiprotein complex. It acts directly on governing neuronal progenitor cell fate promoting differentiation over proliferation. Researchers have found CEND1 to affect cell cycle arrest in neuronal populations steering progenitor cells towards post-mitotic states essential for healthy neural tissue maturation. The presence of CEND1 in neurogenesis stages establishes it as an important player in the shaping of the neuronal landscape in the brain.

Pathways

Several cell cycle-related pathways involve CEND1 in regulating the transition from proliferation to differentiation in neural progenitors. It interacts with key proteins such as p27^Kip1 and cyclin-dependent kinases. These interactions are important in coordinating neurogenesis and neuronal pathway specification. CEND1 ensures proper function and cooperation with other elements of the neurogenic program including pathways like Notch signaling to regulate the temporal and spatial aspects of neuronal differentiation.

Research has linked CEND1 to neurodevelopmental conditions such as microcephaly and certain forms of epilepsy. Malfunctions or dysregulation of CEND1 can result in impaired neuronal differentiation leading to disturbed neural circuit formation. In these contexts CEND1 interacts with proteins like p53 which governs cell cycle arrest and apoptosis offering insights into how disrupted CEND1 expression contributes to the pathophysiology of these neurological disorders. Understanding these relationships provides potential therapeutic targets for correcting or mitigating such conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Involved in neuronal differentiation.
See full target information CEND1
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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Cell journal 25:264-272 PubMed37210647

2023

Down-Regulation of CEND1 Expression Contributes to The Progression and Temozolomide Resistance of Glioma.

Applications

Unspecified application

Species

Unspecified reactive species

Zhou Houjun,Bai Peng

Cell cycle (Georgetown, Tex.) 22:796-807 PubMed36503346

2022

Long noncoding RNA relieves chondrocyte inflammation by targeting miR-8082/ in osteoarthritis.

Applications

Unspecified application

Species

Unspecified reactive species

Pu Wang,Yuhao Wang,Baoan Ma

Neural regeneration research 17:130-136 PubMed34100448

2021

Cell cycle exit and neuronal differentiation 1-engineered embryonic neural stem cells enhance neuronal differentiation and neurobehavioral recovery after experimental traumatic brain injury.

Applications

Unspecified application

Species

Unspecified reactive species

Ren Wang,Dian-Xu Yang,Ying-Liang Liu,Jun Ding,Yan Guo,Wan-Hai Ding,Heng-Li Tian,Fang Yuan

iScience 24:102645 PubMed34142067

2021

Arhgef2 regulates neural differentiation in the cerebral cortex through mRNA mA-methylation of Npdc1 and Cend1.

Applications

Unspecified application

Species

Unspecified reactive species

Pei Zhou,Yifei Qi,Xiang Fang,Miaomiao Yang,Shuxin Zheng,Caihua Liao,Fengying Qin,Lili Liu,Hong Li,Yan Li,Ethiraj Ravindran,Chuanbo Sun,Xinshu Wei,Wen Wang,Liang Fang,Dingding Han,Changgeng Peng,Wei Chen,Na Li,Angela M Kaindl,Hao Hu

Cells 9: PubMed32630355

2020

Loss of ZC4H2 and RNF220 Inhibits Neural Stem Cell Proliferation and Promotes Neuronal Differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Longlong Zhang,Maosen Ye,Liang Zhu,Jingmei Cha,Chaocui Li,Yong-Gang Yao,Bingyu Mao

Nature 561:253-257 PubMed30177828

2018

An orthogonal proteomic survey uncovers novel Zika virus host factors.

Applications

Unspecified application

Species

Unspecified reactive species

Pietro Scaturro,Alexey Stukalov,Darya A Haas,Mirko Cortese,Kalina Draganova,Anna Płaszczyca,Ralf Bartenschlager,Magdalena Götz,Andreas Pichlmair
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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