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AB230239

Anti-CEP120 antibody

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(2 Publications)

Rabbit Polyclonal CEP120 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CEP120 aa 1-300.

View Alternative Names

CCDC100, CEP120, Centrosomal protein of 120 kDa, Cep120, Coiled-coil domain-containing protein 100

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CEP120 antibody (AB230239)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CEP120 antibody (AB230239)

Paraffin-embedded human spleen tissue stained for CEP120 using ab230239 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CEP120 antibody (AB230239)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CEP120 antibody (AB230239)

Paraffin-embedded human lung tissue stained for CEP120 using ab230239 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human CEP120 aa 1-300. The exact immunogen used to generate this antibody is proprietary information.

Q8N960

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CEP120 also known as Centrosomal Protein 120 is a protein in humans encoded by the CEP120 gene. It has a molecular mass of about 121 kDa. CEP120 is primarily expressed in the centrosome an important organelle in cells responsible for microtubule organization. This protein is critical in the regulation of centrosome duplication and spindle assembly during cell division ensuring proper chromosome segregation.
Biological function summary

CEP120 plays a significant role in centrosome and cilia formation. It is an essential part of the core centrosome complex and directly interacts with other centrosomal proteins required for centriole elongation. Its activity ensures centrosome stability and proper cilia function impacting cellular sensory and signaling processes.

Pathways

CEP120 is implicated in microtubule-related pathways. It integrates into the centrosome duplication pathway closely interacting with proteins like CPAP (CENPJ) and STIL which are central to centrosome biogenesis. CEP120 also influences the pathway of ciliogenesis alongside proteins such as IFT88 being essential in the construction of primary cilia.

CEP120 mutations have been linked to ciliopathies such as Jeune asphyxiating thoracic dystrophy and some forms of microcephalic primordial dwarfism. Abnormal CEP120 expression or function is related to defective cilia and centrosome activities affecting processes like ciliary signaling. The protein interacts with OFD1 and alterations in this interaction may exacerbate these conditions illustrating its connection within the broader landscape of ciliary and developmental disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. Required for centriole duplication and maturation during mitosis and subsequent ciliogenesis (By similarity). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed : 27185865).
See full target information CEP120
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

iScience 26:105745 PubMed36590171

2023

Centrosomal protein 120 promotes centrosome amplification and gastric cancer progression via USP54-mediated deubiquitination of PLK4.

Applications

Unspecified application

Species

Unspecified reactive species

Chenggang Zhang,Xianxiong Ma,Guanxin Wei,Xiuxian Zhu,Peng Hu,Xiang Chen,Dianshi Wang,Yuan Li,Tuo Ruan,Weikang Zhang,Kaixiong Tao,Chuanqing Wu

Cells 12: PubMed36611882

2022

Human Placental Endothelial Cell and Trophoblast Heterogeneity and Differentiation Revealed by Single-Cell RNA Sequencing.

Applications

Unspecified application

Species

Unspecified reactive species

Han Li,Hao Peng,Wei Hong,Yingying Wei,Haojun Tian,Xiaojie Huang,Linyan Jia,Jing Zheng,Tao Duan,Qizhi He,Kai Wang
View all publications
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Product promise

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