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Rabbit Polyclonal CEP128 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human CEP128 aa 900 to C-terminus.

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Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CEP128 antibody (AB224041), expandable thumbnail

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human CEP128 aa 900 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q6ZU80

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IHC-P
Human
Tested

Tested
Tested

Species

Human

Dilution info
1/200.00000 - 1/500.00000
Notes

Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Associated Products

Select an associated product type

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Target data

Function

Alternative names

C14orf145, C14orf61, CEP128, Centrosomal protein of 128 kDa, Cep128

Recommended products

Rabbit Polyclonal CEP128 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human CEP128 aa 900 to C-terminus.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Fragment Protein within Human CEP128 aa 900 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q6ZU80
Purification technique

Affinity purification Immunogen

Concentration
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Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

CEP128 also known as centrosomal protein 128 kDa plays a mechanical role in cell division. It has a molecular mass of approximately 128 kDa and localizes in the centrosome of cells. CEP128 shows expression in various tissues especially those with high cellular proliferation rates. Its primary function involves regulating microtubule organization during cell division processes. CEP128 facilitates centrosome anchoring and ultimately contributes to accurate chromosomal segregation.

Biological function summary

CEP128 interacts with other proteins as part of the centrosomal complex. It assists in maintaining centrosome cohesion and stability. This ability to manage centrosome integrity ensures proper duplication and segregation during mitosis. The centrosomal complex including CEP128 protects cells from errors in chromosome distribution reducing genomic instability.

Pathways

CEP128 integrates into critical cellular signaling processes. It participates in the cell cycle control and mitotic spindle assembly pathways. CEP128 connects with proteins such as PLK4 and CEP152 which are essential for centriole duplication and spindle assembly checkpoint regulation. These biological pathways emphasize CEP128's role in ensuring orderly cell cycle progression.

Associated diseases and disorders

CEP128 shows relevance to certain cancers and developmental disorders. Its perturbation can result in centrosome-related abnormalities notably contributing to breast cancer formation due to chromosomal instability. Additionally its association with genes like BRCA1 links CEP128 to genetic pathways tied to cancer susceptibility. Disorders involving improper microtubule dynamics or chromosome mis-segregation often correlate with altered CEP128 expression or function.

Product promise

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1 product image

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CEP128 antibody (ab224041), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CEP128 antibody (ab224041)

    Paraffin-embedded human pancreas tissue stained for CEP128 using ab224041 at 1/200 dilution in immunohistochemical analysis.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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