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AB84545

Anti-CEP170 antibody

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(4 Publications)

Rabbit Polyclonal CEP170 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human CEP170 aa 1500 to C-terminus.

View Alternative Names

FAM68A, KAB, KIAA0470, CEP170, Centrosomal protein of 170 kDa, Cep170, KARP-1-binding protein, KARP1-binding protein

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-CEP170 antibody (AB84545)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-CEP170 antibody (AB84545)

Detection of Human CEP170 by Immunocytochemistry.

Sample : NBF-fixed asynchronous HeLa cells.
Antibody : ab84545 used at a dilution of 1/100.
Detection : Red-fluorescent Alexa Fluor 594 goat anti-rabbit IgG.

Immunocytochemistry/ Immunofluorescence - Anti-CEP170 antibody (AB84545)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-CEP170 antibody (AB84545)

Detection of Human CEP170 by Immunocytochemistry.

Sample : NBF-fixed asynchronous HeLa cells.
Antibody : ab84545 used at a dilution of 1/100.
Detection : Red-fluorescent Alexa Fluor 594 goat anti-rabbit IgG.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Synthetic Peptide within Human CEP170 aa 1500 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q5SW79

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/500", "ICCIF-species-notes": "<p>Permeabilization with Triton-X 100 is recommended.</p>" }, "Chimpanzee": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rabbit": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 6.8 - 7.4 Preservative: 0.09% Sodium azide Constituents: Tris buffered saline, 0.1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Centrosomal Protein 170 (CEP170) also known as KIAA0470 is a significant component of centrosomal structures. This protein weighs around 170 kDa and finds widespread expression in various human tissues. At a cellular level CEP170 localizes to the spindle apparatus during mitosis where it plays a role in microtubule organization. Through its mechanical function CEP170 contributes to maintaining the structural integrity of centrosomes and helps in organizing microtubules.
Biological function summary

CEP170 participates in cell cycle regulation and aids in the proper division of cells. It engages in a complex with other proteins at the centrosome such as CDK5RAP2 and PCM1 to ensure proper microtubule attachment and alignment during mitosis. Its interactions help to maintain centrosome cohesion and spindle formation therefore ensuring accurate chromosome segregation. Failure in these processes can lead to aneuploidy and potentially to cellular malfunction.

Pathways

CEP170 operates within the microtubule organizing center and the cell cycle checkpoint pathways. It interacts closely with proteins like PLK1 which is important for cell cycle progression and spindle formation. Such interactions indicate its role in multiple cellular pathways that orchestrate successful division and prevent genomic instability. CEP170 also plays a part in the regulation of the p53 signaling pathway influencing cellular responses to DNA damage.

CEP170 has associations with certain cancers such as breast cancer and glioblastoma. In these contexts changes in CEP170 expression or malfunction can disrupt normal cell division therefore contributing to tumorigenesis. Its deregulation often accompanies alterations in other proteins like Aurora A kinase which may complicate normal mitotic processes. These associations indicate that CEP170's role in maintaining genomic integrity can impact disease progression and offers potential avenues for targeted therapy.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a role in microtubule organization (PubMed : 15616186). Required for centriole subdistal appendage assembly (PubMed : 28422092).
See full target information CEP170
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Cell communication and signaling : CCS 23:319 PubMed40598224

2025

A novel mechanism of sperm midpiece epididymal maturation and the role of CCDC112 in sperm midpiece formation and establishing an optimal flagella waveform.

Applications

Unspecified application

Species

Unspecified reactive species

Maddison L Graffeo,Joseph Nguyen,Farin Yazdan Parast,Jessica E M Dunleavy,Denis Korneev,Hongyi Yang,Hidenobu Okuda,Anne E O'Connor,Donald F Conrad,Reza Nosrati,Brendan J Houston,Moira K O'Bryan

Cell 175:984-997.e24 PubMed30388455

2018

A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade.

Applications

Unspecified application

Species

Unspecified reactive species

Livnat Jerby-Arnon,Parin Shah,Michael S Cuoco,Christopher Rodman,Mei-Ju Su,Johannes C Melms,Rachel Leeson,Abhay Kanodia,Shaolin Mei,Jia-Ren Lin,Shu Wang,Bokang Rabasha,David Liu,Gao Zhang,Claire Margolais,Orr Ashenberg,Patrick A Ott,Elizabeth I Buchbinder,Rizwan Haq,F Stephen Hodi,Genevieve M Boland,Ryan J Sullivan,Dennie T Frederick,Benchun Miao,Tabea Moll,Keith T Flaherty,Meenhard Herlyn,Russell W Jenkins,Rohit Thummalapalli,Monika S Kowalczyk,Israel Cañadas,Bastian Schilling,Adam N R Cartwright,Adrienne M Luoma,Shruti Malu,Patrick Hwu,Chantale Bernatchez,Marie-Andrée Forget,David A Barbie,Alex K Shalek,Itay Tirosh,Peter K Sorger,Kai Wucherpfennig,Eliezer M Van Allen,Dirk Schadendorf,Bruce E Johnson,Asaf Rotem,Orit Rozenblatt-Rosen,Levi A Garraway,Charles H Yoon,Benjamin Izar,Aviv Regev

Experimental hematology 43:1031-1046.e12 PubMed26366677

2015

FANCA safeguards interphase and mitosis during hematopoiesis in vivo.

Applications

IF

Species

Unspecified reactive species

Zahi Abdul-Sater,Donna Cerabona,Elizabeth Sierra Potchanant,Zejin Sun,Rikki Enzor,Ying He,Kent Robertson,W Scott Goebel,Grzegorz Nalepa

Genes & development 26:1797-810 PubMed22855792

2012

Meier-Gorlin syndrome mutations disrupt an Orc1 CDK inhibitory domain and cause centrosome reduplication.

Applications

Unspecified application

Species

Unspecified reactive species

Manzar Hossain,Bruce Stillman
View all publications
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Product promise

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