Anti-CEP350 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

CEP350 also known as Centrosome-associated protein 350 is a large protein weighing approximately 350 kDa. It plays an important mechanical role in centrosome structure and function. Expressed mainly in tissues with high proliferative capacity CEP350 anchors microtubules to the centrosomes ensuring proper cell division. The protein localizes to the centrosome and is important for maintaining microtubule organization.

Biological function summary

CEP350 interacts with other centrosomal components to ensure proper spindle formation during mitosis. It is part of the pericentriolar material participating in complex formation with proteins such as ninein and AKAP450. These interactions stabilize the centrosome enabling effective microtubule nucleation and anchoring which are essential for cell cycle progression and cellular integrity.

Pathways

CEP350 contributes to the centrosome cycle and microtubule dynamics regulation. It plays a role in the interphase microtubule pathway coordinating with proteins like pericentrin to manage microtubule organization and stability. CEP350's interaction with the AKAP450 protein complex influences the microtubule-organizing center activity reflecting its role in essential cellular pathways.

Associated diseases and disorders

CEP350 mutations or dysregulation link to microcephaly and retinal degeneration highlighting its role in neural development and visual function. Its association with pericentrin and AKAP450 can also impact ciliogenesis which when impaired may contribute to ciliopathies. Understanding CEP350's involvement in these conditions could lead to insights into their molecular mechanisms and potential therapeutic targets.