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AB230305

Anti-CEP95 antibody

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(2 Publications)

Rabbit Polyclonal CEP95 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CEP95 aa 550 to C-terminus.

View Alternative Names

CCDC45, CEP45, CEP95, Centrosomal protein of 95 kDa, Cep95, Coiled-coil domain-containing protein 45

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CEP95 antibody (AB230305)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CEP95 antibody (AB230305)

Paraffin-embedded human colon-cancer tissue stained for CEP95 using ab230305 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CEP95 antibody (AB230305)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CEP95 antibody (AB230305)

Paraffin-embedded human bladder cancer tissue stained for CEP95 using ab230305 at 1/100 dilution in immunohistochemical analysis.

Western blot - Anti-CEP95 antibody (AB230305)
  • WB

Supplier Data

Western blot - Anti-CEP95 antibody (AB230305)

All lanes:

Western blot - Anti-CEP95 antibody (ab230305) at 1/1000 dilution

All lanes:

Mouse heart tissue lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/10000 dilution

Predicted band size: 95 kDa

Observed band size: 95 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human CEP95 aa 550 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q96GE4

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The CEP95 protein also known as Centrosomal protein of 95 kDa plays a critical role in centrosome and cilia function. Its molecular mass is approximately 95 kilodaltons as its name suggests. Scientists have identified CEP95 in various human tissues with significant expression levels in centrosomes particularly during cell division. The protein localizes to the centrosome the microtubule-organizing center of cells where it participates in the regulation of cilia and flagella.
Biological function summary

The CEP95 protein interacts within the network important for centriole duplication and ciliogenesis making it an essential component of centrosomal complexes. CEP95 associates with other centrosomal proteins to ensure accurate and efficient centrosome duplication. These interactions help facilitate key processes necessary for the integrity and proper functioning of microtubules and cell division.

Pathways

Scientists have implicated CEP95 in the control of the cell cycle specifically within the centrosome cycle and ciliogenesis pathways. CEP95 works closely with proteins such as CEP152 and CEP192 which coordinate alongside CEP95 to regulate centriole duplication. Misregulation of these pathways can lead to disorders associated with improper cell division and ciliopathies highlighting the protein's significance in maintaining cellular function and stability.

Improper function or expression of CEP95 has been linked to microcephaly and some cancer forms. In microcephaly the relationship between CEP95 and proteins like CEP152 becomes critical as they work together in the centrosome cycle for proper brain development. Similarly disruptions in CEP95 function in cancer can lead to uncontrolled cell proliferation. Therefore CEP95 stands as an important component in understanding the delicate balance of cell cycle regulation and its link to human disease.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information CEP95
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Disease markers 2022:7745315 PubMed36618966

2022

Coiled-Coil Domain-Containing Protein 45 Is a Potential Prognostic Biomarker and Is Associated with Immune Cell Enrichment of Hepatocellular Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Shuqing Liu,Lei Jia,Bing Quan,Guang Rong,Min Li,Ronggen Xie,Yanling Cai,Yuzhen Bi,Siyuan Han

Journal of translational medicine 20:120 PubMed35272674

2022

RUNX3-mediated circDYRK1A inhibits glutamine metabolism in gastric cancer by up-regulating microRNA-889-3p-dependent FBXO4.

Applications

Unspecified application

Species

Unspecified reactive species

Haofeng Liu,Qiu Xue,Hongzhou Cai,Xiaohui Jiang,Guangxin Cao,Tie Chen,Yuan Chen,Ding Wang
View all publications
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Product promise

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