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AB136053

Anti-CEP97 antibody

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(1 Publication)

Rabbit Polyclonal CEP97 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human CEP97.

View Alternative Names

LRRIQ2, CEP97, Centrosomal protein of 97 kDa, Cep97, Leucine-rich repeat and IQ domain-containing protein 2

1 Images
Western blot - Anti-CEP97 antibody (AB136053)
  • WB

Unknown

Western blot - Anti-CEP97 antibody (AB136053)

All lanes:

Western blot - Anti-CEP97 antibody (ab136053) at 1/500 dilution

All lanes:

COLO205 cell lysates at 30 µg

Predicted band size: 128 kDa,97 kDa

Observed band size: 180 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human CEP97. The exact immunogen used to generate this antibody is proprietary information.

Q8IW35

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CEP97 also known as centrosomal protein 97 is an important regulator of ciliogenesis and centriole function. The protein has a molecular mass of approximately 97 kDa reflecting its role in these cellular processes. CEP97 is highly expressed in tissues where active cell division or ciliogenesis occurs such as the testis and brain. This protein localizes to the centrosome a critical structure involved in organizing microtubules and ensuring proper cell division.
Biological function summary

CEP97 plays an important role in managing the biogenesis and maintenance of the cellular structures essential for cell division particularly centrioles. It forms a complex with CP110 another centrosomal protein to inhibit primary cilia formation on the mother centriole. The CEP97-CP110 complex controls the timing of cilia assembly making sure that the right cellular conditions exist before cilia formation. Proper functioning of this complex is important for maintaining proper cell cycle progression and cellular architecture.

Pathways

CEP97 is essential to the regulation of the cilia assembly pathway and the centrosome duplication pathway. In these pathways CEP97 interacts with proteins like CP110 and CEP76 modulating their activities to prevent premature cilia formation. Through these pathways CEP97 ensures that centrosomes function correctly during cell division therefore maintaining genomic stability and preventing uncontrolled cell proliferation.

Improper CEP97 function links to ciliopathies and certain cancers. Disruption in CEP97 activities can lead to impaired ciliogenesis contributing to ciliopathies like Bardet-Biedl syndrome. Moreover CEP97's interaction with CP110 connects it to pathways involved in tumorigenesis highlighting its potential role in cancer development. Studying these interactions and the resulting cellular dysfunctions is important for understanding the molecular basis of these diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation (PubMed : 17719545, PubMed : 30375385). Required for recruitment of CCP110 to the centrosome (PubMed : 17719545).
See full target information CEP97
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

BMC cancer 16:594 PubMed27488834

2016

Casein kinase 1α has a non-redundant and dominant role within the CK1 family in melanoma progression.

Applications

Unspecified application

Species

Unspecified reactive species

Tobias Sinnberg,Jun Wang,Birgit Sauer,Birgit Schittek
View all publications
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Product promise

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