JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB215042

Anti-CES2 antibody

Be the first to review this product! Submit a review

|

(3 Publications)

Sheep Polyclonal EST2C antibody. Suitable for WB and reacts with Mouse samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Mouse Ces2c aa 1 to C-terminus.

View Alternative Names

Ces2, Ces2c, Acylcarnitine hydrolase, ACH M1, Carboxylesterase 2, Carboxylic ester hydrolase, Peroxisome proliferator-inducible acylcarnitine hydrolase, CES 2

1 Images
Western blot - Anti-CES2 antibody (AB215042)
  • WB

Supplier Data

Western blot - Anti-CES2 antibody (AB215042)

All lanes:

Western blot - Anti-CES2 antibody (ab215042) at 1/1000 dilution

All lanes:

Mouse liver tissue lysate

Predicted band size: 62 kDa

Observed band size: 58-62 kDa

false

Key facts

Host species

Sheep

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Mouse Ces2c aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q91WG0

style
left-column

Alternative Products

Primary Antibodies

AB137606

Anti-CES2 antibody

Western blot - Anti-CES2 antibody (AB137606)

  • 0
  • 0
Primary Antibodies

AB126970

Anti-CES2 antibody

Western blot - Anti-CES2 antibody (AB126970)

  • 0
  • 0
Primary Antibodies

AB88439

Anti-CES2 antibody

Western blot - Anti-CES2 antibody (AB88439)

  • 0
  • 0
Primary Antibodies

AB184957

Anti-CES2 antibody [EPR14856]

RabMAb|Recombinant

Western blot - Anti-CES2 antibody [EPR14856] (AB184957)

  • 1
  • 1

Complementary Products

Secondary Antibodies

AB150113

Goat Anti-Mouse IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (AB150113)

  • 5
  • 15
Primary Antibodies

AB250793

Anti-CES2 antibody [EPR14856] - BSA and Azide free

RabMAb|Recombinant

Western blot - Anti-CES2 antibody [EPR14856] - BSA and Azide free (AB250793)

  • 0
  • 0
Primary Antibodies

AB213693

Anti-FSP27 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FSP27 antibody (AB213693)

  • 0
  • 0
Primary Antibodies

AB45957

Anti-Liver Carboxylesterase 1/CES1 antibody

BOND RX™ Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Liver Carboxylesterase 1/CES1 antibody (AB45957)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/2000", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
The IgG fraction of immunized serum was purified by antigen affinity chromatography.
Storage buffer
Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Carboxylesterase 2 (CES2) also known as intestinal carboxylesterase is an enzyme with a molecular mass of approximately 60 kDa. CES2 hydrolyzes esters and amides affecting metabolism of drugs and xenobiotics. It is found mainly in the liver and small intestine with lesser expression in the colon kidney and brain. This distribution enables CES2 to play a role in both intestinal and systemic drug metabolism.
Biological function summary

CES2 acts in the hydrolysis process converting prodrugs into active compounds. It functions independently and is not typically part of a larger complex. This enzyme demonstrates broad substrate specificity impacting the metabolic activation of several therapeutic agents. Its activity affects the bioavailability and activation of medicines such as irinotecan and capecitabine which are used in cancer treatments.

Pathways

CES2 takes part in the drug metabolism pathway involving cytochrome P450 enzymes. It interacts with CYP3A4 one of the key enzymes in this system and facilitates the conversion of chemical compounds into pharmacologically active or inactive metabolites. CES2 also participates in lipid metabolism affecting the ester and triglyceride hydrolysis alongside lipases and other related enzymes.

CES2 has implications in colorectal cancer and liver disease conditions where altered drug metabolism influences disease progression and treatment efficacy. It shows associations with irinotecan activation a drug used for treating colorectal cancer and links with UDP-glucuronosyltransferases (UGTs) that also engage in drug metabolism. Understanding CES2's function aids in predicting patient responses to drug therapies and refining treatment strategies for these conditions.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Hydrolase with high activity towards palmitoylcarnitine. Is also active with p-nitrophenylacetate and alpha-naphthylacetate. May also hydrolyze retinyl esters (By similarity).
See full target information Ces2c
style
left-column

Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 14:3643 PubMed37339977

2023

Antioxidant hepatic lipid metabolism can be promoted by orally administered inorganic nanoparticles.

Applications

Unspecified application

Species

Unspecified reactive species

Jie Cai,Jie Peng,Juan Feng,Ruocheng Li,Peng Ren,Xinwei Zang,Zezong Wu,Yi Lu,Lin Luo,Zhenzhen Hu,Jiaying Wang,Xiaomeng Dai,Peng Zhao,Juan Wang,Mi Yan,Jianxin Liu,Renren Deng,Diming Wang

Frontiers in oncology 12:1012058 PubMed36338744

2022

Multi-spectral immunofluorescence evaluation of the myeloid, T cell, and natural killer cell tumor immune microenvironment in chordoma may guide immunotherapeutic strategies.

Applications

Unspecified application

Species

Unspecified reactive species

Diana C Lopez,Yvette L Robbins,Joshua T Kowalczyk,Wiem Lassoued,James L Gulley,Markku M Miettinen,Gary L Gallia,Clint T Allen,James W Hodge,Nyall R London

Frontiers in pharmacology 13:843872 PubMed35250593

2022

Combined Use of Bicyclol and Berberine Alleviates Mouse Nonalcoholic Fatty Liver Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Hu Li,Nan-Nan Liu,Jian-Rui Li,Biao Dong,Mei-Xi Wang,Jia-Li Tan,Xue-Kai Wang,Jing Jiang,Lei Lei,Hong-Ying Li,Han Sun,Jian-Dong Jiang,Zong-Gen Peng
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com