AB157183

Anti-CETP antibody [EPR13]

RabMAb
Recombinant
What is this?

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(3 Publications)

Rabbit Recombinant Monoclonal CETP antibody. Suitable for IP, WB and reacts with Human samples. Cited in 3 publications.

View Alternative Names

Cholesteryl ester transfer protein, Lipid transfer protein I, CETP

2 Images

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Immunoprecipitation - Anti-CETP antibody [EPR13] (AB157183)

Detection of CETP by Western Blot of Immunprecipitate. Human plasma lysates immunoprecipitated using ab157183 at 1/10 dilution.

All lanes:

Immunoprecipitation - Anti-CETP antibody [EPR13] (ab157183) at 1/1000 dilution

All lanes:

immunoprecipitation pellets from Human plasma at 10 µg

Predicted band size: 181 kDa,33 kDa,38 kDa,55 kDa

Observed band size: 50 kDa

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Unknown

Western blot - Anti-CETP antibody [EPR13] (AB157183)

All lanes:

Western blot - Anti-CETP antibody [EPR13] (ab157183) at 1/1000 dilution

All lanes:

Human plasma lysate at 10 µg

Secondary

All lanes:

Goat anti-rabbit HRP at 1/2000 dilution

Predicted band size: 55 kDa

false

Carrier free

Anti-CETP antibody [EPR13] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR13

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IP, WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "1/10 - 1/100", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Product details

Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please contact us for more information.

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CETP also known as Cholesteryl Ester Transfer Protein is a plasma glycoprotein with a molecular mass of approximately 74 kDa. It is primarily expressed in the liver and circulates in the bloodstream. CETP mediates the transfer of cholesteryl esters and triglycerides between high-density lipoproteins (HDL) and low-density lipoproteins (LDL) influencing lipid balance in human plasma. This protein is essential for regulating the distribution and composition of HDL and LDL particles impacting lipid homeostasis.

Biological function summary

CETP plays a role in lipid metabolism by facilitating the redistribution of lipids among various lipoprotein particles. CETP does not function as part of a larger molecular complex but actively interacts with lipoproteins in a reversible manner. Its activity affects the levels of HDL cholesterol often referred to as "good cholesterol" and contributes to maintaining lipid levels within physiological limits. By modulating the lipid exchanges CETP influences atherosclerosis progression and cardiovascular health.

Pathways

CETP interacts significantly with lipoprotein metabolism and reverse cholesterol transport pathways. It works alongside key proteins such as apolipoprotein A-I and apolipoprotein B which are present in HDL and LDL particles respectively. CETP activity in these pathways modulates the cholesterol efflux capability of HDL affecting lipid clearance from tissues back to the liver. These interactions ensure the maintenance of cholesterol equilibrium and are vital in lipid recycling processes.

CETP is closely linked to cardiovascular diseases and atherosclerosis. Elevated CETP activity correlates with low HDL cholesterol levels and higher risk of coronary artery disease. CETP inhibitors have been researched for their potential to increase HDL levels and reduce cardiovascular risk. Furthermore CETP activity influences the pathology of metabolic syndrome where lipid imbalances exacerbate the condition. Proteins related to CETP in these contexts include HDL and LDL which are altered in their distributions by CETP's activity impacting disease progression and management.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL (PubMed : 24293641, PubMed : 3281933, PubMed : 3600759). Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (PubMed : 17237796).

See full target information CETP

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in physiology 12:799096 PubMed35082691

2022

Expressing the Human Cholesteryl Ester Transfer Protein Minigene Improves Diet-Induced Fatty Liver and Insulin Resistance in Female Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Lin Zhu,Julia An,Sivaprakasam Chinnarasu,Thao Luu,Yasminye D Pettway,Kelly Fahey,Bridget Litts,Hye-Young H Kim,Charles R Flynn,MacRae F Linton,John M Stafford

eLife 10: PubMed34609279

2021

A sex-specific evolutionary interaction between and .

Applications

Unspecified application

Species

Unspecified reactive species

Isabel Gamache,Marc-André Legault,Jean-Christophe Grenier,Rocio Sanchez,Eric Rhéaume,Samira Asgari,Amina Barhdadi,Yassamin Feroz Zada,Holly Trochet,Yang Luo,Leonid Lecca,Megan Murray,Soumya Raychaudhuri,Jean-Claude Tardif,Marie-Pierre Dubé,Julie Hussin

Cell death & disease 7:e2300 PubMed27441652

2016

RNA-binding protein Musashi2 induced by RANKL is critical for osteoclast survival.

Applications

Unspecified application

Species

Unspecified reactive species

T Fujiwara,J Zhou,S Ye,H Zhao

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CETP antibody [EPR13]

Immunoprecipitation - Anti-CETP antibody [EPR13] (AB157183)

Western blot - Anti-CETP antibody [EPR13] (AB157183)

Related conjugates and formulations (1)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

Product promise