Anti-CFHL2 antibody [EPR25758-30]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

CFHL2 also known as Complement Factor H-Related 2 is a small protein with a mass of approximately 29 kDa. It belongs to the family of complement factor H-related proteins. This protein is expressed predominantly in the liver and also in several other tissues including the blood. Its mechanical function involves binding to certain molecules in the extracellular matrix and surfaces which affects the regulation of the complement system.

Biological function summary

CFHL2 plays a role in the immune system by participating in the regulation of the complement activation. It does not operate alone but is part of a group of proteins that modulate the complement system which helps clear pathogens from an organism. CFHL2 can act by competing with complement factor H potentially altering the activity of the complement system and influencing immune responses.

Pathways

CFHL2 interacts with the alternative pathway of the complement system. This pathway is one of three that facilitate the complement system an important part of innate immunity. Its interaction with complement factor H influences the level of activity within this pathway impacting how the body responds to pathogens. CFHL2 in this way indirectly connects to other proteins regulating the immune response.

Associated diseases and disorders

CFHL2 has been associated with age-related macular degeneration and atypical hemolytic uremic syndrome. In these conditions an imbalance in the complement system is observed where CFHL2's role in modulating complement factor H comes into play. Such disruption in balance contributes to the pathology of these diseases and implicates related proteins like complement factor H in disease progression.